公开(公告)号：US20060106022A1

公开(公告)日：2006-05-18

申请号：US11233725

申请日：2005-09-23

Applicant: Jian Liu ,  Raymond Patch ,  Mark Player

Inventor： Jian Liu ,  Raymond Patch ,  Mark Player

IPC: C07D487/02 ,  A61K31/498

CPC classification number: C07D487/04

Abstract: The invention is directed to compounds of Formula I: wherein Q, Y, A are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein kinases, especially Aurora-1, Aurora-2 and Aurora-3 kinases.

公开(公告)号：US20050131022A1

公开(公告)日：2005-06-16

申请号：US10970865

申请日：2004-10-22

Applicant: Mark Player ,  Nand Baindur ,  Benjamin Brandt ,  Naresh Chadha ,  Raymond Patch ,  Davoud Asgari ,  Taxiarchis Georgiadis

Inventor： Mark Player ,  Nand Baindur ,  Benjamin Brandt ,  Naresh Chadha ,  Raymond Patch ,  Davoud Asgari ,  Taxiarchis Georgiadis

IPC: A61K31/16 ,  A61K31/195 ,  A61K31/452 ,  A61K31/4545 ,  C07D223/12 ,  C07D265/30 ,  C07D279/12 ,  C07D307/68 ,  C07D405/12 ,  C07D409/12 ,  C07D45/02

CPC classification number: C07D405/12 ,  C07D207/416 ,  C07D233/90 ,  C07D307/68 ,  C07D409/12

Abstract: The invention is directed to compounds of Formulae I: wherein A, R1, R2, R3, R4, X, and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract translation: 本发明涉及式I的化合物：其中A，R 1，R 2，R 3，R 4， 说明书中列出了SUB，X和W，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

公开(公告)号：US20050049274A1

公开(公告)日：2005-03-03

申请号：US10894940

申请日：2004-07-20

Applicant: Mark Wall ,  Mark Player ,  Raymond Patch ,  Sanath Meegalla ,  Jian Liu ,  Carl Illig ,  Wing Cheung ,  Jinsheng Chen ,  Davoud Asgari

Inventor： Mark Wall ,  Mark Player ,  Raymond Patch ,  Sanath Meegalla ,  Jian Liu ,  Carl Illig ,  Wing Cheung ,  Jinsheng Chen ,  Davoud Asgari

IPC: A61P35/00 ,  C07D215/22 ,  C07D215/227 ,  C07D401/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  C07D471/02 ,  A61K31/47 ,  C07D215/36

CPC classification number: C07D215/227 ,  C07D401/04 ,  C07D409/04 ,  C07D413/04 ,  C07D413/14 ,  C07D417/04 ,  C07D471/04 ,  Y02P20/582

Abstract: The invention is directed to compounds of Formulae I and II: wherein R1, R2, R3, R5, R6, Y1, Y2, Y3, Y4 and X are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract translation: 本发明涉及式I和II的化合物：其中R 1，R 2，R 3，R 5，R 6，Y 1，Y 2， 3>，Y 4和X在说明书中列出，以及其抑制蛋白酪氨酸激酶，特别是c-fms激酶的溶剂合物，水合物，互变异构体或其药学上可接受的盐。

公开(公告)号：US20050004112A1

公开(公告)日：2005-01-06

申请号：US10831216

申请日：2004-04-26

Applicant: Mark Player ,  Nand Baindur ,  Benjamin Brandt ,  Naresh Chadha ,  Raymond Patch ,  Davoud Asgari ,  Taxiarchis Georgiadis

Inventor： Mark Player ,  Nand Baindur ,  Benjamin Brandt ,  Naresh Chadha ,  Raymond Patch ,  Davoud Asgari ,  Taxiarchis Georgiadis

IPC: A61K31/16 ,  A61K31/195 ,  A61K31/452 ,  A61K31/4545 ,  A61K31/55 ,  A61P35/00 ,  C07D207/34 ,  C07D207/42 ,  C07D213/81 ,  C07D223/12 ,  C07D231/16 ,  C07D231/38 ,  C07D261/18 ,  C07D265/02 ,  C07D265/30 ,  C07D279/12 ,  C07D295/14 ,  C07D307/68 ,  C07D307/71 ,  C07D307/72 ,  C07D401/12 ,  C07D405/00 ,  C07D405/12 ,  C07D491/04

CPC classification number: C07D213/81 ,  C07D231/38 ,  C07D265/02 ,  C07D307/68 ,  C07D307/71 ,  C07D405/12 ,  C07D491/04

Abstract: The invention is directed to compounds of Formulae I, II and III: wherein A, R1, R2, R3, R4, X, Y and W are set forth in the specification, as well as solvates, hydrates, tautomers or pharmaceutically acceptable salts thereof, that inhibit protein tyrosine kinases, especially c-fms kinase.

Abstract translation: 本发明涉及式I，II和III的化合物：其中A，R 1，R 2，R 3，R 4，X，Y和W在说明书中列出，以及溶剂合物，水合物，互变异构体或其药学上可接受的盐 ，抑制蛋白酪氨酸激酶，特别是c-fms激酶。