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公开(公告)号:US06992100B2
公开(公告)日:2006-01-31
申请号:US10450745
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , John David Jandzinski
IPC分类号: A61K31/403 , C07D209/56
CPC分类号: A61K31/403 , A61K31/407 , A61K31/4745
摘要: A novel class of tetracyclic compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新的四环化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克的用途。
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公开(公告)号:US06939890B2
公开(公告)日:2005-09-06
申请号:US10629992
申请日:2003-07-30
IPC分类号: C07D209/22 , A61K31/404 , C07D207/337
CPC分类号: C07D209/22
摘要: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新型吲哚以及这些化合物用于抑制脂肪酸介导的释放脂肪酸用于治疗炎性疾病如败血性休克的用途。
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公开(公告)号:US06251921B1
公开(公告)日:2001-06-26
申请号:US09312593
申请日:1999-05-14
申请人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
发明人: Jolie Anne Bastian , Nickolay Yuri Chirgadze , Michael Lyle Denney , Matthew Joseph Fisher , Robert James Foglesong , Richard Waltz Harper , Mary George Johnson , Valentine Joseph Klimkowski , Todd Jonathan Kohn , Ho-Shen Lin , Michael Patrick Lynch , Jefferson Ray McCowan , Alan David Palkowitz , Michael Enrico Richett , Daniel Jon Sall , Gerald Floyd Smith , Kumiko Takeuchi , Jennifer Marie Tinsley , Minsheng Zhang
IPC分类号: A61K314436
CPC分类号: C07D333/62 , A61K31/381 , A61K31/4025 , A61K31/4178 , A61K31/422 , A61K31/4439 , A61K31/454 , A61K31/4545 , A61K31/497 , A61K31/5377 , A61K31/55 , C07D231/12 , C07D233/56 , C07D249/08 , C07D333/56 , C07D333/58 , C07D333/64 , C07D333/66 , C07D409/04 , C07D409/06 , C07D409/12 , C07D413/06
摘要: This application relates to the use as thrombin inhibitors, coagulation inhibitors and thromboembolic disorder agents of diamines of formula I as defined herein. It also provides novel compounds of formula I, processes and intermediates for their preparation, and pharmaceutical formulations comprising the novel compounds of formula I.
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公开(公告)号:US06916840B2
公开(公告)日:2005-07-12
申请号:US10450860
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer , Edward C R Smith
IPC分类号: A61K31/404 , A61P29/00 , A61P43/00 , C07D209/12 , C07D209/60 , A61K31/40 , C07D209/56
CPC分类号: C07D209/60
摘要: A novel class of benz[g]indole compounds is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 公开了一类新颖的苯并[g]吲哚化合物以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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公开(公告)号:US06635670B2
公开(公告)日:2003-10-21
申请号:US10260450
申请日:2002-09-27
IPC分类号: A61K31404
CPC分类号: C07D209/22
摘要: A class of novel indole is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 一类新型吲哚与所述化合物一起用于抑制sPLA2介导的脂肪酸释放以治疗炎性疾病如脓毒性休克。
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公开(公告)号:US06391908B1
公开(公告)日:2002-05-21
申请号:US09856942
申请日:2001-05-30
申请人: Nicholas James Bach , Richard Waltz Harper , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett
发明人: Nicholas James Bach , Richard Waltz Harper , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett
IPC分类号: A61K31404
CPC分类号: C07D209/22
摘要: A class of novel oxime indoles is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of inflammatory diseases such as septic shock.
摘要翻译: 公开了一类新型肟吲哚以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗炎症性疾病如败血性休克的用途。
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17.[4-(Benzo[B]thiophen-2-yl) Pyrimidin-2-yl]-amine derivatives as IKK-beta inhibitors for the treatment of cancer and inflammatory diseases 失效
标题翻译: [4-(苯并[B]噻吩-2-基)嘧啶-2-基] - 胺衍生物作为治疗癌症和炎性疾病的IKK-β抑制剂公开(公告)号:US07547691B2
公开(公告)日:2009-06-16
申请号:US12093024
申请日:2006-11-15
申请人: Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
发明人: Karl Robert Dahnke , Ho-Shen Lin , Michael Enrico Richett , Chuan Shih , Q May Wang , Bo Zhang
IPC分类号: C07D409/04 , A61K31/506
CPC分类号: C07D409/04
摘要: The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.
摘要翻译: 本发明提供式I化合物:可用于治疗癌症和炎性疾病。
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公开(公告)号:US06933313B2
公开(公告)日:2005-08-23
申请号:US10467965
申请日:2002-03-15
IPC分类号: A61K31/403 , A61P1/04 , A61P1/18 , A61P9/10 , A61P11/00 , A61P11/06 , A61P19/00 , A61P19/02 , A61P19/06 , A61P25/28 , A61P27/14 , A61P29/00 , A61P31/00 , A61P43/00 , C07D209/88 , C07D403/12 , C07D409/04
CPC分类号: C07D403/12 , A61K31/403 , C07D209/88 , C07D409/04 , Y02A50/401
摘要: Carbazoles of formula (I) with R2=hydroxyfunctional amide (hydroxamic or esters) are disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了具有R 2 =羟基官能酰胺(异羟肟酸或酯)的式(I)的咔唑以及这些化合物用于抑制sPLA 2介导的脂肪酸释放的用途 治疗脓毒性休克等病症。
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公开(公告)号:US06872743B2
公开(公告)日:2005-03-29
申请号:US10450633
申请日:2001-12-06
申请人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
发明人: Douglas Wade Beight , Michael Dean Kinnick , Ho-Shen Lin , John Michael Morin, Jr. , Michael Enrico Richett , Daniel Jon Sall , Jason Scott Sawyer
IPC分类号: A61K31/403 , A61P1/00 , A61P1/18 , A61P7/00 , A61P11/00 , A61P11/06 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P29/00 , A61P37/08 , A61P43/00 , C07D209/80 , C07D209/94 , C07D209/56
CPC分类号: C07D209/80 , C07D209/94
摘要: A novel class of tetracyclic compounds represented by the formula I wherein R1, R2, R3, R4, R5, R6, R7, A, B, C, D, E, and n are as defined is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of Inflammatory Diseases such as septic shock.
摘要翻译: 由式I代表的新一类四环化合物,其中R1,R2,R3,R4,R5,R6,R7,A,B,C,D,E和n定义同上, 抑制sPLA2介导的脂肪酸释放治疗炎症性疾病如脓毒性休克。
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公开(公告)号:US06713645B1
公开(公告)日:2004-03-30
申请号:US09688106
申请日:2000-10-13
申请人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
发明人: Nicholas James Bach , Susan Elizabeth Draheim , Robert Delane Dillard , Edward David Mihelich , Jason Scott Sawyer , Douglas Wade Beight , Michael LeRoy Phillips , Tulio Suarez , Daniel Jon Sall , Jolie Anne Bastian , Michael Lyle Denney , Gary Alan Hite , Michael Dean Kinnick , Robert Theodore Vasileff , John Michael Morin, Jr. , Ho-Shen Lin , Michael Enrico Richett , Richard Waltz Harper , John McNeill McGill, III , Benjamin Alan Anderson , Nancy Kay Harn , Richard James Loncharich , Richard Walter Schevitz
IPC分类号: C07C6976
CPC分类号: C07D409/04 , C07D209/88 , C07F9/5728
摘要: A class of novel tricyclics is disclosed together with the use of such compounds for inhibiting sPLA2 mediated release of fatty acids for treatment of conditions such as septic shock.
摘要翻译: 公开了一类新型三环类药物,以及这些化合物用于抑制sPLA2介导的脂肪酸释放以治疗诸如败血性休克的病症。
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