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公开(公告)号:US5464862A
公开(公告)日:1995-11-07
申请号:US180728
申请日:1994-01-13
IPC分类号: C07D311/58 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4025 , A61K31/55 , A61P19/10
摘要: Methods and pharmaceutical compositions for reducing bone loss are disclosed. 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment of bone loss due to osteoporosis or other conditions. An exemplary 3,4-diarylchroman is centchroman (3,4-trans-2,2-dimethyl-3-phenyl-4-[p-(beta-pyrrolidinoethoxy)phenyl]-7-methoxychroman). Formulations include tablets and other forms suitable for oral administration and controlled-release subdermal implants.
摘要翻译: 公开了减少骨丢失的方法和药物组合物。 将3,4-二芳基苯并二氢吡喃及其药学上可接受的盐配制成用于治疗由骨质疏松症或其他病症引起的骨丢失的药物。 示例性3,4-二芳基苯并二氢吡喃是中性苯并二氢吡喃(3,4-反式-2,2-二甲基-3-苯基-4- [对 - (β-吡咯烷基)乙氧基)苯基] -7-甲氧基苯并二氢吡喃)。 制剂包括适于口服给药和受控释放的皮下植入物的片剂和其它形式。
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公开(公告)号:US5280040A
公开(公告)日:1994-01-18
申请号:US29729
申请日:1993-03-11
IPC分类号: C07D311/58 , A61K31/35 , A61K31/352 , A61K31/40 , A61K31/4025 , A61K31/55 , A61P19/10
摘要: Methods and pharmaceutical compositions for reducing bone loss are disclosed. 3,4-diarylchromans and their pharmaceutically acceptable salts are formulated into medicaments for the treatment of bone loss due to osteoporosis or other conditions. An exemplary 3,4-diarylchroman is centchroman (3,4-trans-2,2-dimethyl-3-phenyl-4-[p-(beta-pyrrolidinoethoxy)phenyl]-7-methoxy-chroman). Formulations include tablets and other forms suitable for oral administration and controlled-release subdermal implants.
摘要翻译: 公开了减少骨丢失的方法和药物组合物。 将3,4-二芳基苯并二氢吡喃及其药学上可接受的盐配制成用于治疗由骨质疏松症或其他病症引起的骨丢失的药物。 示例性的3,4-二芳基苯并二氢吡喃是中性色满(3,4-反式-2,2-二甲基-3-苯基-4-(对 - (β-吡咯烷基乙氧基)苯基)-7-甲氧基 - 苯并二氢吡喃)。 制剂包括适于口服给药和受控释放的皮下植入物的片剂和其它形式。
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