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公开(公告)号:US06376530B1
公开(公告)日:2002-04-23
申请号:US09550972
申请日:2000-04-17
IPC分类号: C07D20944
CPC分类号: C07D209/48 , A61K31/4035 , A61K31/472 , C07D217/22
摘要: The invention encompasses novel compounds of Formula I as well as a method of treating NMDA mediated diseases comprising administration to a patient in need of such treatment a non-toxic amount of a compound of Formula I effective to block the NMDA NR2B receptor sub-unit. The invention also encompasses certain pharmaceutical compositions for the treatment of NMDA mediated diseases comprising compounds of Formula I and a pharmaceutically acceptable carrier.
摘要翻译: 本发明包括式I的新化合物以及治疗NMDA介导的疾病的方法,包括向需要这种治疗的患者施用无毒量的有效阻断NMDA NR2B受体亚单位的式I化合物。 本发明还包括用于治疗包含式I化合物和药学上可接受的载体的NMDA介导的疾病的某些药物组合物。
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12.N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B Antagonists 失效
标题翻译: N-取代的非芳基 - 杂环酰胺基NMDA / NR2B拮抗剂公开(公告)号:US07259157B2
公开(公告)日:2007-08-21
申请号:US10114685
申请日:2002-04-02
申请人: Nigel J. Liverton , John W. Butcher , Charles McIntyre , Christopher F. Claiborne , David A. Claremon , John A. McCauley , Joseph J. Romano , Wayne Thompson , Peter M. Munson
发明人: Nigel J. Liverton , John W. Butcher , Charles McIntyre , Christopher F. Claiborne , David A. Claremon , John A. McCauley , Joseph J. Romano , Wayne Thompson , Peter M. Munson
IPC分类号: A61K31/554 , A61K31/4965 , A61K31/44 , A61K31/425 , A61K31/52
CPC分类号: C07D265/30 , C07D207/09 , C07D211/26 , C07D241/04 , C07D401/12 , C07D409/12 , C07D417/12 , C07D473/00 , C07D487/04
摘要: Compounds represented by Formula (I): or pharmaceutically acceptable salts thereof, are effective as NMDA NR2B antagonists useful for relieving pain.
摘要翻译: 由式(I)表示的化合物或其药学上可接受的盐作为可用于缓解疼痛的NMDA NR2B拮抗剂是有效的。
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公开(公告)号:US06207687B1
公开(公告)日:2001-03-27
申请号:US09358199
申请日:1999-07-21
IPC分类号: A61K314439
CPC分类号: C07D401/04 , C07D403/04
摘要: There are disclosed compounds of formula (I) and pharmaceutically acceptable salts thereof which may be useful for the treatment of cytokine mediated diseases such as arthritis.
摘要翻译: 公开了式(I)化合物及其药学上可接受的盐,其可用于治疗细胞因子介导的疾病如关节炎。
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14.N-(2,4-Dioxo-2,3,4,5-tetrahydro-1H-1,5-benzodiazepin-3yl) -3- amides 失效
标题翻译: N-(2,4-二氧代-2,3,4,5-四氢-1H-1,5-苯并二氮杂-3基)-3-酰胺公开(公告)号:US5691331A
公开(公告)日:1997-11-25
申请号:US474801
申请日:1995-06-07
IPC分类号: A61P9/06 , A61K31/55 , C07D243/12
CPC分类号: C07D243/12
摘要: This invention is concerned with novel compounds represented by structural formula I ##STR1## which are useful in the treatment of arrhythmia.
摘要翻译: 本发明涉及可用于治疗心律失常的结构式I表示的新化合物。
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公开(公告)号:US5631251A
公开(公告)日:1997-05-20
申请号:US481662
申请日:1995-06-07
IPC分类号: A61K31/55 , A61K31/551 , A61P9/06 , C07D243/14 , C07D243/24
CPC分类号: C07D243/14
摘要: This invention is concerned with novel compounds represented by structural formula I ##STR1## Z is C.sub.0-6 alkyl; and R.sup.1 is phenyl or mono or disubstituted phenyl, where the substitutents are Cl, and CF.sub.3,or pharmaceutically acceptable salts, hydrates and crystal forms thereof which are useful in the treatment of arrhythmia.
摘要翻译: 本发明涉及由结构式I表示的新化合物,其中Z是C0-6烷基; 并且R 1是苯基或单取代或二取代的苯基,其中取代基是Cl,和CF 3,或其药学上可接受的盐,水合物和晶体形式,其可用于治疗心律失常。
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公开(公告)号:US5428157A
公开(公告)日:1995-06-27
申请号:US155670
申请日:1993-11-22
申请人: John J. Baldwin , David A. Claremon , Jason M. Elliott , Nigel Liverton , David C. Remy , Harold G. Selnick
发明人: John J. Baldwin , David A. Claremon , Jason M. Elliott , Nigel Liverton , David C. Remy , Harold G. Selnick
IPC分类号: A61K31/55 , A61K31/551 , A61P9/06 , A61P9/08 , A61P9/10 , C07D243/14 , C07D243/12
CPC分类号: C07D243/14
摘要: 3-Acylamino-5-Aminobenzo[1,5]diazepines are useful in the treatment of arrhythmia. The compounds have structural formulae: ##STR1##
摘要翻译: 3-酰基氨基-5-氨基苯并[1,5]二氮杂可用于治疗心律失常。 化合物具有结构式:
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公开(公告)号:US5679672A
公开(公告)日:1997-10-21
申请号:US646249
申请日:1996-05-14
申请人: John J. Baldwin , David A. Claremon , Jason M. Elliott , Nigel Liverton , David C. Remy , Harold G. Selnick
发明人: John J. Baldwin , David A. Claremon , Jason M. Elliott , Nigel Liverton , David C. Remy , Harold G. Selnick
IPC分类号: A61K31/395 , A61K31/415 , A61K31/55 , A61P9/06 , C07D487/04 , C07D498/04 , C07D513/04
CPC分类号: C07D487/04
摘要: Compounds of structures (I) and (Ia) are Class III antiarrhythmic agents ##STR1##
摘要翻译: PCT No.PCT / US94 / 13546 Sec。 371日期:1996年5月14日 102(e)日期1996年5月14日PCT 1994年11月21日PCT PCT。 出版物WO95 / 14694 日期:1995年6月1日结构(I)和(Ia)的化合物是III类抗心律失常药物(I)
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公开(公告)号:US5441952A
公开(公告)日:1995-08-15
申请号:US42963
申请日:1993-04-05
申请人: David A. Claremon , Nigel Liverton
发明人: David A. Claremon , Nigel Liverton
IPC分类号: C07D243/24 , A61K31/55 , A61K31/551 , A61P7/02 , C07D401/06 , C07D211/62 , A61K38/00
CPC分类号: C07D401/06
摘要: Fibrinogen receptor antagonists of the ##STR1## are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets, for example ##STR2##
摘要翻译: 公开了用于抑制纤维蛋白原与血小板结合和抑制血小板聚集的纤维蛋白原受体拮抗剂,例如
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公开(公告)号:US5426185A
公开(公告)日:1995-06-20
申请号:US156331
申请日:1993-11-22
申请人: John J. Baldwin , David A. Claremon , Jason M. Elliott , Nigel Liverton , David C. Remy , Harold G. Selnick
发明人: John J. Baldwin , David A. Claremon , Jason M. Elliott , Nigel Liverton , David C. Remy , Harold G. Selnick
IPC分类号: A61K31/5513 , A61K31/55 , A61K31/551 , A61K38/00 , A61P9/00 , A61P9/06 , C07D243/14 , C07D243/24 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07K5/06 , C07K5/078 , C07D243/12
CPC分类号: C07D401/04 , A61K31/55 , C07D243/14 , C07D243/24 , C07D401/12 , C07D403/12 , C07D405/04 , C07D405/12 , C07D409/12 , C07D413/10 , C07D413/12 , C07D471/04 , C07D487/04 , C07D495/04 , C07K5/06026 , C07K5/06139 , A61K38/00 , Y10S514/821
摘要: Benzo-(1,5)-diazepine derivatives with an amide or urea function in the 3-position are useful in the treatment of arrhythmia. The compounds have structural formulae: ##STR1##
摘要翻译: 具有3-位氨基或脲官能团的苯并(1,5) - 二氮杂衍生物可用于治疗心律失常。 化合物具有结构式:
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20.N-(1-alkyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo�B!�1,4!diazepi n-3yl)-acetamides 失效
标题翻译: N-(1-烷基-5-苯基-2,3,4,5-四氢-1H-苯并[B] [1,4]二氮杂-3基) - 乙酰胺公开(公告)号:US5726171A
公开(公告)日:1998-03-10
申请号:US616239
申请日:1996-03-13
IPC分类号: C07D249/12 , A61K31/55 , A61P9/06 , C07D243/12
CPC分类号: C07D243/12
摘要: This invention is concerned with novel compounds represented by structural formula I ##STR1## which are useful in the treatment of arrhythmia.
摘要翻译: 本发明涉及可用于治疗心律失常的结构式I表示的新化合物。
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