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公开(公告)号:US20050014257A1
公开(公告)日:2005-01-20
申请号:US10858500
申请日:2004-06-01
申请人: Rosanne Crooke , Mark Graham
发明人: Rosanne Crooke , Mark Graham
IPC分类号: A61K48/00 , C07H21/02 , C07H21/04 , C12N20060101 , C12N15/113 , C12Q1/68
CPC分类号: C07H21/04 , C07H21/02 , C12N15/113 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要: Compounds, compositions and methods are provided for modulating the expression of C-reactive protein. The compositions comprise oligonucleotides, targeted to nucleic acid encoding C-reactive protein. Methods of using these compounds for modulation of C-reactive protein expression and for diagnosis and treatment of disease associated with expression of C-reactive protein are provided.
摘要翻译: 提供化合物,组合物和方法用于调节C-反应蛋白的表达。 组合物包含针对编码C反应蛋白的核酸的寡核苷酸。 提供了使用这些化合物调节C-反应蛋白表达和用于诊断和治疗与C-反应蛋白表达相关的疾病的方法。
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公开(公告)号:US20060019920A1
公开(公告)日:2006-01-26
申请号:US11179128
申请日:2005-07-11
申请人: C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
发明人: C. Bennett , Susan Freier , Brett Monia , Nicholas Dean , Hong Zhang , Robert McKay , Donna Ward , William Gaarde , Jacqueline Wyatt , Andrew Watt , Rosanne Crooke , Mark Graham , Pamela Nero , Kenneth Dobie , Alexander Borchers , Eric Marcusson , Mark Roach
CPC分类号: C12N9/1205 , Y02P20/582
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of MEKK4. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding MEKK4. Methods of using these compounds for modulation of MEKK4 expression and for treatment of diseases associated with expression of MEKK4 are provided.
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13.
公开(公告)号:US20050287558A1
公开(公告)日:2005-12-29
申请号:US11124020
申请日:2005-05-05
申请人: Rosanne Crooke , Mark Graham , Steven Mah
发明人: Rosanne Crooke , Mark Graham , Steven Mah
CPC分类号: C12N15/113 , C12N2310/11 , C12N2310/111 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2320/30 , C12Q1/6883 , C12Q2600/106 , C12Q2600/136 , C12Q2600/156 , C12Q2600/158
摘要: Compounds, compositions and methods are provided for modulating the expression of apolipoprotein B. The compositions comprise oligonucleotides, targeted to nucleic acid encoding apolipoprotein B. Methods of using these compounds for modulation of apolipoprotein B expression and for diagnosis and treatment of diseases and conditions associated with expression of apolipoprotein B are provided.
摘要翻译: 提供了用于调节载脂蛋白B表达的化合物,组合物和方法。该组合物包含靶向编码载脂蛋白B的核酸的寡核苷酸。使用这些化合物调节载脂蛋白B表达并用于诊断和治疗与 提供载脂蛋白B的表达。
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公开(公告)号:US20050153924A1
公开(公告)日:2005-07-14
申请号:US11013543
申请日:2004-12-15
申请人: C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
发明人: C. Bennett , Brett Monia , Susan Murray , Madeline Butler , Nicholas Dean , Rosanne Crooke , Mark Graham , Hong Zhang , Susan Freier , Brenda Baker , Eric Marcusson , Jacqueline Wyatt , Lex Cowsert , Kenneth Dobie , Andrew Watt
IPC分类号: A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68
CPC分类号: C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of Interferon gamma receptor 2. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding Interferon gamma receptor 2. Methods of using these compounds for modulation of Interferon gamma receptor 2 expression and for treatment of diseases associated with expression of Interferon gamma receptor 2 are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节干扰素γ受体2的表达。组合物包含靶向编码干扰素γ受体2的核酸的反义化合物,特别是反义寡核苷酸。使用这些化合物调节干扰素γ受体2的方法 提供了与干扰素γ受体2表达相关的疾病的表达和治疗。
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公开(公告)号:US20050043256A1
公开(公告)日:2005-02-24
申请号:US10619253
申请日:2003-07-15
申请人: Rosanne Crooke , Mark Graham
发明人: Rosanne Crooke , Mark Graham
IPC分类号: A61K38/00 , A61K45/06 , C07H20060101 , C12N9/02 , C12N15/113 , A61K48/00 , C07H21/02
CPC分类号: A61K45/06 , A61K38/00 , C12N9/0083 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y114/19001 , Y02P20/582 , C12N2310/3525
摘要: Antisense compounds, compositions and methods are provided for modulating the expression of stearoyl-CoA desaturase. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding stearoyl-CoA desaturase. Methods of using these compounds for modulation of stearoyl-CoA desaturase expression and for treatment of diseases associated with expression of stearoyl-CoA desaturase are provided.
摘要翻译: 提供反义化合物,组合物和方法用于调节硬脂酰辅酶A去饱和酶的表达。 组合物包含靶向编码硬脂酰辅酶A去饱和酶的核酸的反义化合物,特别是反义寡核苷酸。 提供了使用这些化合物调节硬脂酰辅酶A去饱和酶表达和治疗与硬脂酰辅酶A去饱和酶表达相关的疾病的方法。
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16.
公开(公告)号:US20060035858A1
公开(公告)日:2006-02-16
申请号:US11200710
申请日:2005-08-10
申请人: Richard Geary , Zhengrong Yu , Rosanne Crooke
发明人: Richard Geary , Zhengrong Yu , Rosanne Crooke
IPC分类号: A61K48/00
CPC分类号: C12N15/113 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3525
摘要: Methods for the rapid and long-term lowering of lipid levels in human subjects and for the treatment of conditions associated with elevated LDL-cholesterol and elevated apolipoprotein B are provided.
摘要翻译: 提供了快速和长期降低人类受试者脂质水平和治疗与升高的LDL-胆固醇和升高的载脂蛋白B相关的病症的方法。
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