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    PROCESS FOR THE PREPARATION OF PHENYL SUBSTITUTED 3 - DIFLUOROMETHYL - 1 -METHYL - 1H - PYRAZOLE - 4 - CARBOXYLIC ACID N-METHOXY- [1 -METHYL- 2 PHENYLETHYL] AMIDES
    15.
    发明申请
    PROCESS FOR THE PREPARATION OF PHENYL SUBSTITUTED 3 - DIFLUOROMETHYL - 1 -METHYL - 1H - PYRAZOLE - 4 - CARBOXYLIC ACID N-METHOXY- [1 -METHYL- 2 PHENYLETHYL] AMIDES 有权
    制备苯基取代的3-二氟甲基-1-甲基-1H-吡唑-4-羧酸N-甲氧基 - [1-甲基-2-苯基]氨基甲酰胺的方法

    公开(公告)号：US20150018562A1

    公开(公告)日：2015-01-15

    申请号：US14374547

    申请日：2013-02-26

    Applicant: Syngenta Participations AG

    Inventor： Daniel Stierli ,  Harald Walter ,  Michael Rommel ,  Reinhard Georg Hanreich ,  Martin Zeller ,  Thomas Vettiger ,  Tomas Smejkal

    IPC: C07D231/12

    CPC classification number: C07D231/12 ,  C07D231/14

    Abstract: The invention relates to a process for the preparation of a compound of formula (I), wherein R1, R2 and R3 are as defined in claim 1, which process comprises a) adding a compound of formula (II), in the presence of an inert organic solvent to a mixture comprising an organic nitrite of formula (III) (R4—O—N═O (III)), wherein R4 is C1-C8 alkyl, a compound of formula (IV), and an inert organic solvent; b) reacting the resulting compound of formula (V), with H2N—O—CH3 to the compound of formula (VII), c) reducing the compound of formula (VII) to the compound of formula (VIII), d) and reacting the compound of formula VIII with a compound of formula (IX), in which R* is halogen, hydroxy or C1-6 alkoxy, to the compound of formula (I).

    Abstract translation: 本发明涉及一种制备式（I）化合物的方法，其中R 1，R 2和R 3如权利要求1所定义，该方法包括：a）将式（II）化合物在 惰性有机溶剂加入到包含式（III）的有机亚硝酸酯（R4-O-N = O（III））的混合物中，其中R4是C1-C8烷基，式（IV）化合物和惰性有机溶剂; b）将得到的式（Ⅴ）化合物与H 2 N-O-CH 3反应于式（Ⅶ）化合物，c）将式（Ⅶ）化合物还原为式（Ⅷ）化合物，d） 式Ⅸ化合物与式（Ⅸ）化合物反应，其中R *为卤素，羟基或C 1-6烷氧基。

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