公开(公告)号：US5651997A

公开(公告)日：1997-07-29

申请号：US712798

申请日：1996-09-12

申请人： Tadashi Makino ,  Shigeyuki Marunaka ,  Soichiro Imoto

发明人： Tadashi Makino ,  Shigeyuki Marunaka ,  Soichiro Imoto

IPC分类号： A61K33/10 ,  A61K33/06 ,  A61K31/13 ,  A61K33/00 ,  A61K33/08

CPC分类号： A61K33/10

摘要： An antacid composition comprises, as antacid ingredients, a hydrotalcite and dihydroxyaluminium aminoacetate in such a ratio that the former/the latter equals 30/70 to 90/10 (by weight). The composition may further comprises a readily acting or rapid effecting antacid ingredient such as a magnesium hydroxide in an amount of 10 to 50% by weight. The antacid composition is improved in antacid properties and rapid effecting properties, and is useful as a pharmaceutical composition comprising the antacid composition, a carrier, an additive, an additional pharmaceutically active ingredient and so on. The total amount of the antacid ingredients in the pharmaceutical composition may be 10% by weight or more. The pharmaceutical composition may be formed into a fine granule or a granule with utilizing granulation, or into a tablet by compression-molding.

摘要翻译： 抗酸剂组合物包含作为抗酸成分的水滑石和氨基乙酸二羟基铝，其比例为前者/后者等于30/70至90/10（重量比）。 该组合物还可以包含10至50重量％的容易起作用或快速作用的抗酸成分，例如氢氧化镁。 抗酸剂组合物的抗酸性能和快速效果性能得到改善，并且可用作包含抗酸组合物，载体，添加剂，另外的药物活性成分等的药物组合物。 药物组合物中的抗酸成分的总量可以为10重量％以上。 药物组合物可以通过造粒形成细颗粒或颗粒，或通过压缩成型形成片剂。