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11.PYRROLO[2,3-d]PYRIMIDINE TROPOMYSIN-RELATED KINASE INHIBITORS 有权
标题翻译: 吡咯并[2,3-d]吡咯烷TROPOMYSIN相关激酶抑制剂公开(公告)号:US20120258950A1
公开(公告)日:2012-10-11
申请号:US13439131
申请日:2012-04-04
申请人: Mark David Andrews , Sharanjeet Kaur Bagal , Karl Richard Gibson , Kiyoyuki Omoto , Thomas Ryckmans , Sarah Elizabeth Skerratt , Paul Anthony Stupple
发明人: Mark David Andrews , Sharanjeet Kaur Bagal , Karl Richard Gibson , Kiyoyuki Omoto , Thomas Ryckmans , Sarah Elizabeth Skerratt , Paul Anthony Stupple
IPC分类号: A61K31/519 , A61P25/00 , A61K31/52 , C07D487/04 , C07D473/00
CPC分类号: C07D487/04 , A61K31/519 , C07D513/04
摘要: The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中取代基如本文所述,及其在药物中的用途,特别是作为Trk拮抗剂。
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12.
公开(公告)号:US08846698B2
公开(公告)日:2014-09-30
申请号:US13439131
申请日:2012-04-04
申请人: Mark David Andrews , Sharanjeet Kaur Bagal , Karl Richard Gibson , Kiyoyuki Omoto , Thomas Ryckmans , Sarah Elizabeth Skerratt , Paul Anthony Stupple
发明人: Mark David Andrews , Sharanjeet Kaur Bagal , Karl Richard Gibson , Kiyoyuki Omoto , Thomas Ryckmans , Sarah Elizabeth Skerratt , Paul Anthony Stupple
IPC分类号: C07D487/04 , A61K31/519 , A61P25/04
CPC分类号: C07D487/04 , A61K31/519 , C07D513/04
摘要: The present invention relates to compounds of Formula (I) and their pharmaceutically acceptable salts, wherein the substituents are as described herein, and their use in medicine, in particular as Trk antagonists.
摘要翻译: 本发明涉及式(I)化合物及其药学上可接受的盐,其中取代基如本文所述,及其在药物中的用途,特别是作为Trk拮抗剂。
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公开(公告)号:US07410964B2
公开(公告)日:2008-08-12
申请号:US10555034
申请日:2004-05-07
申请人: Kevin Dinnell , Karl Richard Gibson , Timothy Harrison , Richard Alexander Jelley , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
发明人: Kevin Dinnell , Karl Richard Gibson , Timothy Harrison , Richard Alexander Jelley , Alan John Nadin , Paul Joseph Oakley , Andrew Pate Owens , Duncan Edward Shaw , Brian John Williams
IPC分类号: C07D285/22 , A61K31/5415
CPC分类号: C07D279/02
摘要: Compounds of formula I: inhibit gamma-secretase and hence find use in treatment or prevention of Alzheimer's disease.
摘要翻译: 式I化合物:抑制γ-分泌酶,因此可用于治疗或预防阿尔茨海默氏病。
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