公开(公告)号：US20050107285A1

公开(公告)日：2005-05-19

申请号：US10495377

申请日：2002-11-11

Applicant: Steven Edwards ,  Robert Moots

Inventor： Steven Edwards ,  Robert Moots

IPC: A61K38/46 ,  A61P29/00 ,  C07K16/28 ,  G01N33/566 ,  A61K38/00 ,  A61K31/60

CPC classification number: A61K38/465 ,  A61K2039/505 ,  C07K16/283 ,  C07K2317/54 ,  C07K2317/55 ,  C07K2317/77 ,  C12Y301/04011 ,  G01N33/566 ,  G01N2333/70535 ,  G01N2500/04

Abstract: The present invention relates to the use of agents that inhibit FcyRIIIb receptor activity, activation or expression for the treatment of inflammatory conditions such as Rheumatoid Arthritis. The invention also concerns screening methods that may be employed to identify said agents.

Abstract translation: 本发明涉及抑制FcyRIIIb受体活性，活化或表达用于治疗炎性病症如类风湿性关节炎的药物的用途。 本发明还涉及可用于鉴定所述试剂的筛选方法。

公开(公告)号：US08865133B2

公开(公告)日：2014-10-21

申请号：US11800381

申请日：2007-05-04

Applicant: Jeffrey T Haley ,  Steven Edwards

Inventor： Jeffrey T Haley ,  Steven Edwards

IPC: A61K9/68 ,  A61K9/28 ,  A61K9/00 ,  A61K9/20

CPC classification number: A61K9/0056 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2086

Abstract: A bi-layer, oral adhering tablet (troche) made by pressing powders with a bi-layer tablet press, having greater than 80% acacia gum as an adhesive in an adhering layer. In a preferred embodiment, the tablet has about 99% acacia gum.

Abstract translation: 通过用双层压片机挤压粉末制成的双层口服粘合片剂（troche），在粘合层中具有大于80％的阿拉伯树胶作为粘合剂。 在优选的实施方案中，片剂具有约99％的阿拉伯胶。

公开(公告)号：US20080047675A1

公开(公告)日：2008-02-28

申请号：US11901599

申请日：2007-09-18

Applicant: Frank Murray ,  Greg Wendt ,  Steven Edwards ,  Stephen McCullough ,  Guy Super

Inventor： Frank Murray ,  Greg Wendt ,  Steven Edwards ,  Stephen McCullough ,  Guy Super

IPC: D21H11/00

CPC classification number: D21F11/14 ,  B31F1/126 ,  D21H25/005 ,  D21H27/002 ,  D21H27/005 ,  D21H27/008 ,  Y10T428/24446 ,  Y10T428/24455 ,  Y10T428/24479 ,  Y10T428/249965

Abstract: A method of making a cellulosic web includes: forming a nascent web from a papermaking furnish, the nascent web having a generally random distribution of papermaking fiber; b) transferring the web having a generally random distribution of papermaking fiber to a translating transfer surface moving at a first speed; drying the web to a consistency of from about 30 to about 60 percent including compactively dewatering the web prior to or concurrently with transfer to the transfer surface; fabric-creping the web from the transfer surface at a consistency of from about 30 to about 60 percent utilizing a creping fabric with a patterned creping surface, the fabric creping step occurring under pressure in a fabric creping nip defined between the transfer surface and the creping fabric wherein the fabric is traveling at a second speed slower than the speed of said transfer surface, the fabric pattern, nip parameters, velocity delta and web consistency being selected such that the web is creped from the transfer surface and redistributed on the creping fabric such that the web has a plurality of fiber-enriched regions arranged in a pattern corresponding to the patterned creping surface of the fabric, optionally drying the wet web while it is held in the creping fabric. Preferably, the formed web is characterized in that its void volume increases upon drawing.

Abstract translation: 制造纤维素网的方法包括：从造纸配料形成初生纤维网，初生纤维网通常具有造纸纤维的随机分布; b）将具有大致随机分布的造纸纤维的幅材转印到以第一速度移动的平移转印表面; 将幅材干燥至约30％至约60％的稠度，包括在转移到转印表面之前或同时转移至纸幅上的压实脱水; 织物使用具有图案化的起皱表面的起皱织物以约30至约60％的稠度从转印表面起皱织物，织物起皱步骤在压力下在织物起皱辊隙中发生，所述织物起皱辊隙限定在转移表面和起皱之间 织物，其中织物以比所述转移表面的速度慢的第二速度行进，织物图案，辊隙参数，速度增量​​和幅材稠度被选择为使得纤维网从转印表面起皱并重新分布在起皱织物上，如 纤维网具有以对应于织物的图案化起皱表面的图案布置的多个纤维富集区域，任选地在湿纸幅被保持在起皱织物中时干燥。 优选地，所形成的纤维网的特征在于其拉伸时其空隙体积增加。

公开(公告)号：US20070274927A1

公开(公告)日：2007-11-29

申请号：US11800381

申请日：2007-05-04

Applicant: Jeffrey T. Haley ,  Steven Edwards

Inventor： Jeffrey T. Haley ,  Steven Edwards

IPC: A61K9/68 ,  A61K9/28

CPC classification number: A61K9/0056 ,  A61K9/006 ,  A61K9/2018 ,  A61K9/2086

Abstract: A slow-dissolving troche with polyol molecules is disclosed. It may be an adherent troche, preferably adhered to teeth or gums or cheek with acacia gum, or a lollipop or child's pacifier. Consumers are instructed to use the troches at the end of each day and after each meal, at least four times per day to benefit oral health, particularly caries, gingivitis, periodontitis, ear infections, sinus infections, halitosis and risk of Streptococcus mutans infecting their blood from their mouths. The polyol molecules are preferably xylitol. The troches may be made with a bi-layer tablet press rounded on one side and flat on the other, preferably using acacia gum in the flat side layer for adhesion.

Abstract translation: 公开了一种具有多元醇分子的缓慢溶解行为。 它可能是粘附的，优选地粘附在牙齿或牙龈上，或者用阿拉伯树胶或者棒棒糖或儿童的奶嘴贴上脸颊。 指导消费者在每天结束时和每餐后每天至少使用四次以使口腔健康受益，特别是龋齿，牙龈炎，牙周炎，耳部感染，鼻窦感染，口臭和感染变形链球菌的风险。 他们嘴里有血。 多元醇分子优选为木糖醇。 锭子可以用双层压片机制成，其一面是圆形的，另一侧是平的，优选在平坦侧层中使用阿拉伯树胶粘合。

公开(公告)号：US20060237154A1

公开(公告)日：2006-10-26

申请号：US11402609

申请日：2006-04-12

Applicant: Steven Edwards ,  Guy Super ,  Stephen McCullough

Inventor： Steven Edwards ,  Guy Super ,  Stephen McCullough

IPC: B31F1/12 ,  D21H27/30

CPC classification number: D21H27/30 ,  B31F1/07 ,  B31F2201/0743 ,  B31F2201/0756 ,  B31F2201/0764 ,  B31F2201/0766 ,  B31F2201/0784 ,  B31F2201/0787 ,  B31F2201/0789 ,  D21H27/002 ,  Y10T428/24479 ,  Y10T428/24612

Abstract: A multi-ply absorbent sheet of cellulosic fiber with continuous outer surfaces is provided an absorbent core between the outer surfaces. The absorbent core includes a non-woven fiber network having: (i) a plurality of pileated fiber enriched regions of relatively high local basis weight interconnected by way of (ii) a plurality of lower local basis weight linking regions whose fiber orientation is biased along the direction between pileated regions interconnected thereby, and (iii) a plurality of fiber-deprived cellules between the fiber enriched and linking regions, also being characterized by a local basis weight lower than the fiber enriched regions. The cellules provide a sponge-like internal structure of low fiber density regions.

Abstract translation: 具有连续外表面的纤维素纤维的多层吸收性片材在外表面之间设置有吸收芯。 吸收芯包括无纺纤维网，其具有：（i）通过（ii）多个下部局部基重重量连接区互连的多个堆积纤维富集区域，所述区域具有相对较高的局部基重， 在其间相互连接的堆积区域之间的方向，以及（iii）纤维富集和连接区域之间的多个纤维剥夺的细胞团，其特征还在于低于富含纤维的区域的局部基础重量。 细胞提供了低密度纤维密度区域的海绵状内部结构。

公开(公告)号：US20050241787A1

公开(公告)日：2005-11-03

申请号：US11108458

申请日：2005-04-18

Applicant: Frank Murray ,  Greg Wendt ,  Steven Edwards ,  Stephen McCullough ,  Guy Super

Inventor： Frank Murray ,  Greg Wendt ,  Steven Edwards ,  Stephen McCullough ,  Guy Super

IPC: B31F1/12 ,  D21F11/14 ,  D21H25/00 ,  D21H27/00

CPC classification number: D21F11/14 ,  B31F1/126 ,  D21H25/005 ,  D21H27/002 ,  D21H27/005 ,  D21H27/008 ,  Y10T428/24446 ,  Y10T428/24455 ,  Y10T428/24479 ,  Y10T428/249965

Abstract: A method of making a cellulosic web includes: forming a nascent web from a papermaking furnish, the nascent web having a generally random distribution of papermaking fiber; b) transferring the web having a generally random distribution of papermaking fiber to a translating transfer surface moving at a first speed; drying the web to a consistency of from about 30 to about 60 percent including compactively dewatering the web prior to or concurrently with transfer to the transfer surface; fabric-creping the web from the transfer surface at a consistency of from about 30 to about 60 percent utilizing a creping fabric with a patterned creping surface, the fabric creping step occurring under pressure in a fabric creping nip defined between the transfer surface and the creping fabric wherein the fabric is traveling at a second speed slower than the speed of said transfer surface, the fabric pattern, nip parameters, velocity delta and web consistency being selected such that the web is creped from the transfer surface and redistributed on the creping fabric such that the web has a plurality of fiber-enriched regions arranged in a pattern corresponding to the patterned creping surface of the fabric, optionally drying the wet web while it is held in the creping fabric. Preferably, the formed web is characterized in that its void volume increases upon drawing.

Abstract translation: 制造纤维素网的方法包括：从造纸配料形成初生纤维网，初生纤维网通常具有造纸纤维的随机分布; b）将具有大致随机分布的造纸纤维的幅材转印到以第一速度移动的平移转印表面; 将幅材干燥至约30％至约60％的稠度，包括在转移到转印表面之前或同时转移至纸幅上的压实脱水; 织物使用具有图案化的起皱表面的起皱织物以约30至约60％的稠度从转印表面起皱织物，织物起皱步骤在压力下在织物起皱辊隙中发生，所述织物起皱辊隙限定在转移表面和起皱之间 织物，其中织物以比所述转移表面的速度慢的第二速度行进，织物图案，辊隙参数，速度增量​​和幅材稠度被选择为使得纤维网从转印表面起皱并重新分布在起皱织物上，如 纤维网具有以对应于织物的图案化起皱表面的图案布置的多个纤维富集区域，任选地在湿纸幅被保持在起皱织物中时干燥。 优选地，所形成的纤维网的特征在于其拉伸时其空隙体积增加。

公开(公告)号：US20050103455A1

公开(公告)日：2005-05-19

申请号：US10964613

申请日：2004-10-15

Applicant: Steven Edwards ,  David White ,  Frank Harper ,  John Dwiggins

Inventor： Steven Edwards ,  David White ,  Frank Harper ,  John Dwiggins

IPC: D21F11/00 ,  D21F11/14 ,  B31F1/12

CPC classification number: D21F11/145 ,  D21F11/006 ,  D21F11/14 ,  Y10T428/24455

Abstract: The present invention is a method of making a near-premium quality paper product having good strength and absorbency characteristics and a product made by that method. The invention is also a method for retaining a high ash content within a paper web formed by conventional wet pressing. The present invention is also a method for retaining a high percentage of softening agent within a paper web that includes such an agent. Further, the present invention is a soft absorbent paper product having a high void volume. Finally, the invention is also a method for producing a soft, absorbent, and near premium paper product having a high void volume using an undulatory crepe blade having a multiplicity of serrulations in its rake surface which presents differentiated creping angles and/or rake angles as to the paper being creped.

Abstract translation: 本发明是制造具有良好强度和吸收特性的近乎优质的纸制品的方法和由该方法制成的产品。 本发明还是一种通过常规湿法压制形成的纸幅中保持高灰分含量的方法。 本发明也是一种在包含这种试剂的纸幅内保持高百分比的软化剂的方法。 此外，本发明是具有高空隙体积的软吸收性纸制品。 最后，本发明也是一种用于生产具有高空隙体积的柔软的，吸收性的和接近优质的纸制品的方法，所述纸制品具有高的空隙体积，该波纹绉纱刀片在其前刀面上具有多个锯齿状，其具有不同的起伏角和/或前角， 纸张被起皱。

公开(公告)号：US06287426B1

公开(公告)日：2001-09-11

申请号：US09392700

申请日：1999-09-09

Applicant: Steven Edwards ,  Ingvar Klerelid ,  Anders Lindén

Inventor： Steven Edwards ,  Ingvar Klerelid ,  Anders Lindén

IPC: D21F900

CPC classification number: D21F11/006

Abstract: A paper machine for manufacturing a structured soft paper web are described, which machine has a wet section, a press section, a drying section and a web-carrying clothing running around a suction device close to a smooth impermeable belt in the press section for the creation of a transfer point. In accordance with the invention, structuring means for structuring the web are arranged between the press section and the drying section. The structuring means comprise either said clothing in the shape of a permeable wire, the structure of which is made up of depressions and arched surface parts, including knuckles in a quantity of 25-150 knuckles per cm2, and a suction device that, at a vacuum of 40-80 kPa, draws the web to the structured side of the wire so that the web acquires the structure of the wire, wherein the wire operates at a speed less than or equal to the speed of the belt, or a creping doctor that is located in a space between the belt and the clothing and in scraping contact with the belt so as to loose the web during simultaneous crinkling, the suction device having a suction gap for initial suction of the web firmly to the clothing for transfer to a drying cylinder. The web-carrying clothing operates then at a speed that is less than the speed of the belt.

Abstract translation: 描述了一种用于制造结构化的软纸幅的造纸机，该机器具有湿部分，压榨部分，干燥部分和在靠近压榨部分的平滑不渗透带的抽吸装置周围运行的卷筒纸 创建转移点。 根据本发明，用于构造网的结构装置布置在压榨部和干燥部之间。 结构装置包括形状为可渗透丝线的所述衣服，其结构由凹陷和拱形表面部分组成，包括每平方厘米25-150关节的指节和一个抽吸装置， 真空度为40-80kPa，将幅材牵引到线的结构化侧面，使得幅材获得线的结构，其中线以小于或等于带速度的速度或起皱医生 其位于皮带和衣服之间的空间中并且与皮带刮擦接触以在同时起皱的同时松开卷筒纸，所述抽吸装置具有吸引间隙，用于将织物的初始抽吸牢固地连接到衣服以转移到 干燥筒。 卷筒纸的服装运行速度小于皮带的速度。