公开(公告)号：US06359136B1

公开(公告)日：2002-03-19

申请号：US09716605

申请日：2000-11-20

申请人： Jolie Ann Bastian ,  Matthew Joseph Fisher ,  Richard Waltz Harper ,  Ho-Shen Lin ,  Jefferson Ray McCowan ,  Daniel Jon Sall ,  Gerald Floyd Smith ,  Kumiko Takeuchi ,  Michael Robert Wiley ,  Minsheng Zhang

发明人： Jolie Ann Bastian ,  Matthew Joseph Fisher ,  Richard Waltz Harper ,  Ho-Shen Lin ,  Jefferson Ray McCowan ,  Daniel Jon Sall ,  Gerald Floyd Smith ,  Kumiko Takeuchi ,  Michael Robert Wiley ,  Minsheng Zhang

IPC分类号： C07D47104

CPC分类号： C07D471/04

摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.

摘要翻译： 本申请涉及本文定义的式I（及其药学上可接受的盐）的新型化合物，其制备方法和中间体，包含式I的新型化合物的药物制剂以及式I化合物作为凝血酶抑制剂的用途 。

公开(公告)号：US6133262A

公开(公告)日：2000-10-17

申请号：US429459

申请日：1999-10-28

申请人： Jefferson Ray McCowan ,  John Eldon Toth ,  Daniel Jon Sall

发明人： Jefferson Ray McCowan ,  John Eldon Toth ,  Daniel Jon Sall

IPC分类号： A61K31/4025 ,  A61P7/02 ,  A61P43/00 ,  C07D333/66 ,  C07D409/12 ,  A61K31/535 ,  A61K31/38 ,  C07D333/52 ,  C07D413/04

CPC分类号： C07D409/12 ,  C07D333/66

摘要： This application relates to novel compounds of formula I (and their pharmaceutically acceptable salts), as defined herein, processes and intermediates for their preparation, pharmaceutical formulations comprising the novel compounds of formula I, and the use of the compounds of formula I as thrombin inhibitors.