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11.Facially Amphiphilic Compounds, Compositions, And Uses Thereof In Treating Cancer 审中-公开
标题翻译: 表面两性化合物,组合物及其用途在治疗癌症公开(公告)号:US20120115877A1
公开(公告)日:2012-05-10
申请号:US13214177
申请日:2011-08-20
申请人: Richard W. Scott , Dylan Clements , Yongjiang Xu , Haizhong Tang , Carol Mulrooney , Ehab Khalil , Damian Weaver , Xiaodong Fan
发明人: Richard W. Scott , Dylan Clements , Yongjiang Xu , Haizhong Tang , Carol Mulrooney , Ehab Khalil , Damian Weaver , Xiaodong Fan
IPC分类号: A61K31/496 , A61K31/4025 , A61P35/00 , A61K31/343 , A61P35/02 , A61K31/505 , A61K31/381
摘要: The present invention discloses compositions of facially amphiphilic compounds and their use in methods for treating or reducing cancers in animals, such as humans.
摘要翻译: 本发明公开了表面两亲化合物的组合物及其用于治疗或减少动物如人类的癌症的方法。
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12.Novel thiophene sulfoximines, compositions thereof, and methods treating complement-mediated diseases and conditions 有权
标题翻译: 新型噻吩亚磺酰亚胺,其组合物和治疗补体介导的疾病和病症的方法公开(公告)号:US20070066667A1
公开(公告)日:2007-03-22
申请号:US11375503
申请日:2006-03-14
申请人: Nalin Subasinghe , Shelley Ballentine , Jeremy Travins , Ehab Khalil , Farah Ali , Kristi Leonard , Joan Gushue , Michael Winters , Heather Hufnagel , Maxwell Cummings
发明人: Nalin Subasinghe , Shelley Ballentine , Jeremy Travins , Ehab Khalil , Farah Ali , Kristi Leonard , Joan Gushue , Michael Winters , Heather Hufnagel , Maxwell Cummings
IPC分类号: A61K31/422 , A61K31/381 , C07D413/02 , C07D333/16
CPC分类号: C07D413/12 , C07D333/38 , C07D409/12 , C07D417/12
摘要: Disclosed are compounds for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade. Said compounds are of Formula I or a solvate, hydrate, pharmaceutically acceptable salt, or prodrug thereof; wherein Ra, Rb, and Rc are defined in the specification, as are A Z, Q, R1 and R2.
摘要翻译: 公开了用于治疗由补体级联的经典途径介导的急性或慢性病症症状的化合物。 所述化合物具有式I或其溶剂化物,水合物,药学上可接受的盐或前药; 其中R a,R b和R c在本说明书中定义,AZ,Q,R 1, SUP>和R 2 2。
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13.Novel thiophene amidines, compositions thereof, and methods of treating complement-mediated diseases and conditions 失效
标题翻译: 新型噻吩脒,其组合物和治疗补体介导的疾病和病症的方法公开(公告)号:US20050234081A1
公开(公告)日:2005-10-20
申请号:US10515554
申请日:2003-05-28
申请人: Nalin Subasinghe , Ehab Khalil , Kristi Leonard , Farah Ali , Heather Hufnagel , Jeremy Travins , Shelley Ballentine , Kenneth Wilson , Maxwell Cummings , Wenxi Pan , Joan Gushue , Sanath Meegalla , Mark Wall , Jinsheng Chen
发明人: Nalin Subasinghe , Ehab Khalil , Kristi Leonard , Farah Ali , Heather Hufnagel , Jeremy Travins , Shelley Ballentine , Kenneth Wilson , Maxwell Cummings , Wenxi Pan , Joan Gushue , Sanath Meegalla , Mark Wall , Jinsheng Chen
IPC分类号: C07D333/22 , A61K31/381 , A61K31/404 , A61K31/41 , A61K31/416 , A61K31/4178 , A61K31/4184 , A61K31/4188 , A61K31/422 , A61K31/427 , A61K31/428 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61K31/4535 , A61K31/4709 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/513 , A61K31/5377 , A61K31/662 , A61P1/04 , A61P3/10 , A61P5/14 , A61P5/48 , A61P7/00 , A61P7/06 , A61P7/08 , A61P7/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/02 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/28 , A61P29/00 , A61P31/00 , A61P31/04 , A61P37/00 , A61P37/06 , A61P37/08 , A61P41/00 , A61P43/00 , C07D333/12 , C07D333/38 , C07D333/54 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D495/04 , C07F7/08 , C07F7/10 , C07F9/6553 , C07D49/02
CPC分类号: C07D417/12 , C07D333/38 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D495/04 , C07F7/0812 , C07F9/655345
摘要: Disclosed is a method for treating the symptoms of an acute or chronic disorder mediated by the classical pathway of the complement cascade, comprising administering to a mammal in need of such treatment a therapeutically effective amount of a compound of Formula (I) or a solvate, hydrate or pharmaceutically acceptable salt thereof; wherein R1, R2, R3, R4 and R7 are defined in the specification, Z is SO or SO2, and Ar is an aromatic or heteroaromatic group as defined herein.
摘要翻译: 公开了一种治疗由补体级联的经典途径介导的急性或慢性病症症状的方法,包括向需要这种治疗的哺乳动物施用治疗有效量的式(I)化合物或溶剂合物, 水合物或其药学上可接受的盐; 其中R 1,R 2,R 3,R 4和R 7, 在本说明书中定义,Z是SO或SO 2,Ar是如本文所定义的芳族或杂芳族基团。
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公开(公告)号:US20050004031A1
公开(公告)日:2005-01-06
申请号:US10869430
申请日:2004-06-16
申请人: Nalin Subasinghe , Ehab Khalil , Farah Ali , Heather Hufnagel , Shelley Ballentine , Jeremy Travins , Kristi Leonard , Roger Bone
发明人: Nalin Subasinghe , Ehab Khalil , Farah Ali , Heather Hufnagel , Shelley Ballentine , Jeremy Travins , Kristi Leonard , Roger Bone
CPC分类号: A61K47/60
摘要: The present invention is directed to conjugated complement cascade inhibitors, and a method of treating a patient using a conjugated complement cascade inhibitor.
摘要翻译: 本发明涉及缀合的补体级联抑制剂,以及使用缀合的补体级联抑制剂治疗患者的方法。
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