公开(公告)号：US06693089B1

公开(公告)日：2004-02-17

申请号：US10339905

申请日：2003-01-10

申请人： Jianmin Li ,  Weenna Bucay-Couto ,  Timothy P. Harrah

发明人： Jianmin Li ,  Weenna Bucay-Couto ,  Timothy P. Harrah

IPC分类号： A61K31715

CPC分类号： C08L5/04 ,  A61K47/6957 ,  A61L27/20 ,  A61L27/26 ,  A61L31/041 ,  A61L31/042

摘要： A method of reducing adhesion at a site of trauma includes forming a film from an alginate solution, contacting the film with a cross-linking solution to form a cross-linked mechanically stable sheet, and placing at least a portion of the sheet at the site of trauma. An anti-adhesion barrier includes a sheet of ionically cross-linked alginate having a thickness in a range of 0.25 mm to 10 mm. The sheet has a tear strength sufficient for suturing and repositioning. A drug delivery device includes a cross-linked alginate container that can be filled with a drug.

摘要翻译： 降低创伤部位的粘附性的方法包括从藻酸盐溶液形成膜，使膜与交联溶液接触以形成交联的机械稳定的片材，并将片材的至少一部分放置在位置 的创伤。 抗粘连屏障包括厚度在0.25mm至10mm范围内的离子交联藻酸盐片。 该片具有足以缝合和重新定位的撕裂强度。 药物递送装置包括可以填充药物的交联藻酸盐容器。