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    Fused azole-pyrimidine derivatives
    14.
    发明授权
    Fused azole-pyrimidine derivatives 有权
    熔融唑 - 嘧啶衍生物

    公开(公告)号：US08129386B2

    公开(公告)日：2012-03-06

    申请号：US12414257

    申请日：2009-03-30

    申请人： Mitsuyuki Shimada ,  Toshiki Murata ,  Kinji Fuchikami ,  Hideki Jishita ,  Naoki Omori ,  Issei Kato ,  Mami Miura ,  Klaus Urbahns ,  Florian Gantner ,  Kevin Bacon

    发明人： Mitsuyuki Shimada ,  Toshiki Murata ,  Kinji Fuchikami ,  Hideki Jishita ,  Naoki Omori ,  Issei Kato ,  Mami Miura ,  Klaus Urbahns ,  Florian Gantner ,  Kevin Bacon

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495

    CPC分类号： C07D471/14 ,  C07D487/04

    摘要： The present invention relates to novel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-γ activity.More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoimmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis.The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to PI3K activity in a human or animal subject.

    摘要翻译： 本发明涉及新型稠合吡唑嘧啶衍生物，其制备方法和含有它们的药物制剂。 本发明的稠合唑类嘧啶衍生物对磷脂酰肌醇-3-激酶（PI3K）抑制的效力显着增强，特别是PI3K-γ抑制作用，可用于预防和治疗与PI3K相关的疾病，特别是PI3K-γ活性。 更具体地说，本发明的唑类衍生物可用于治疗和预防以下疾病：炎性和免疫调节性疾病，如哮喘，特应性皮炎，鼻炎，过敏性疾病，慢性阻塞性肺病（COPD），脓毒性休克，关节 疾病，自身免疫疾病如类风湿性关节炎，格雷夫斯病，癌症，心肌收缩性疾病，心力衰竭，血栓栓塞，缺血和动脉粥样硬化。 本发明的化合物还可用于肺动脉高压，肾衰竭，心脏肥大，以及神经变性疾病如帕金森病，阿尔茨海默病，糖尿病和局灶性缺血，因为这些疾病还涉及人或动物中的PI3K活性 学科。

    FUSED AZOLE-PYRIMIDINE DERIVATIVES
    15.
    发明申请
    FUSED AZOLE-PYRIMIDINE DERIVATIVES 有权
    熔融的偶氮吡啶衍生物

    公开(公告)号：US20090270388A1

    公开(公告)日：2009-10-29

    申请号：US12414257

    申请日：2009-03-30

    申请人： Mitsuyuki Shimada ,  Toshiki Murata ,  Kinji Fuchikami ,  Hideki Tsujishita ,  Naoki Omori ,  Issei Kato ,  Mami Miura ,  Klaus Urbahns ,  Florian Gantner ,  Kevin Bacon

    发明人： Mitsuyuki Shimada ,  Toshiki Murata ,  Kinji Fuchikami ,  Hideki Tsujishita ,  Naoki Omori ,  Issei Kato ,  Mami Miura ,  Klaus Urbahns ,  Florian Gantner ,  Kevin Bacon

    IPC分类号： A61K31/519 ,  C07D487/04 ,  A61K31/5377 ,  A61P29/00 ,  A61P37/00 ,  A61P3/10 ,  A61P35/00

    CPC分类号： C07D471/14 ,  C07D487/04

    摘要： The present invention relates to novel fused azolepyriimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-γ activity.More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoimmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis.The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to PI3K activity in a human or animal subject.

    摘要翻译： 本发明涉及新的稠合唑吡喃衍生物，其制备方法和含有它们的药物制剂。 本发明的稠合吡唑嘧啶衍生物对于磷脂酰肌醇-3-激酶（PI3K）抑制的效力显着增强，特别是对于PI3K-γ抑制，可用于预防和治疗与PI3K相关的疾病，特别是PI3K-γ活性。 更具体地说，本发明的唑类衍生物可用于治疗和预防以下疾病：炎性和免疫调节性疾病，如哮喘，特应性皮炎，鼻炎，过敏性疾病，慢性阻塞性肺病（COPD），脓毒性休克，关节 疾病，自身免疫疾病如类风湿性关节炎，格雷夫斯病，癌症，心肌收缩性疾病，心力衰竭，血栓栓塞，缺血和动脉粥样硬化。 本发明的化合物还可用于肺动脉高压，肾衰竭，心脏肥大，以及神经变性疾病如帕金森病，阿尔茨海默病，糖尿病和局灶性缺血，因为这些疾病还涉及人或动物中的PI3K活性 学科。

    Fused azole-pyrimidine derivatives
    16.
    发明授权
    Fused azole-pyrimidine derivatives 有权
    熔融唑 - 嘧啶衍生物

    公开(公告)号：US07511041B2

    公开(公告)日：2009-03-31

    申请号：US10527376

    申请日：2003-09-18

    申请人： Mitsuyuki Shimada ,  Toshiki Murata ,  Kinji Fuchikami ,  Hideki Tsujishita ,  Naoki Omori ,  Issei Kato ,  Mami Miura ,  Klaus Urbahns ,  Florian Gantner ,  Kevin Bacon

    发明人： Mitsuyuki Shimada ,  Toshiki Murata ,  Kinji Fuchikami ,  Hideki Tsujishita ,  Naoki Omori ,  Issei Kato ,  Mami Miura ,  Klaus Urbahns ,  Florian Gantner ,  Kevin Bacon

    IPC分类号： A01N43/58 ,  A01N43/60 ,  A61K31/50 ,  A61K31/495 ,  C07D237/26 ,  C07D237/36 ,  C07D241/36 ,  C07D239/00 ,  C07D471/00 ,  C07D471/04 ,  C07D401/04 ,  C07D401/22 ,  C07D487/00 ,  C07D487/04 ,  C07D491/00 ,  C07D495/00 ,  C07D497/00

    CPC分类号： C07D471/14 ,  C07D487/04

    摘要： The present invention relates to hovel fused azolepyrimidine derivatives, processes for preparing them and pharmaceutical preparations containing them. The fused azolepyrimidine derivatives of the present invention exhibit enhanced potency for phosphotidylinositol-3-kinase (PI3K) inhibition, especially for PI3K-γ inhibition and can be used for the prophylaxis and treatment of diseases associated with PI3K and particularly with PI3K-γ activity. More specifically, the azole derivatives of the present invention are useful for treatment and prophylaxis of diseases as follows: inflammatory and immunoregulatory disorders, such as asthma, atopic dermatitis, rhinitis, allergic diseases, chronic obstructive pulmonary disease (COPD), septic shock, joint diseases, autoixnmune pathologies such as rheumatoid arthritis, and Graves' disease, cancer, myocardial contractility disorders, heart failure, thromboembolism, ischemia, and atherosclerosis. The compounds of the present invention are also useful for pulmonary hypertension, renal failure, cardiac hypertrophy, as well as neurodegenerative disorders such as Parkinson's disease, Alzheimer's disease, diabetes and focal ischemia, since the diseases also relate to PI3K activity in a human or animal subject.

    摘要翻译： 本发明涉及霍夫唑唑吡啶衍生物，其制备方法和含有它们的药物制剂。 本发明的稠合吡唑嘧啶衍生物对于磷脂酰肌醇-3-激酶（PI3K）抑制的效力显着增强，特别是对于PI3K-γ抑制，可用于预防和治疗与PI3K相关的疾病，特别是PI3K-γ活性。 更具体地说，本发明的唑类衍生物可用于治疗和预防以下疾病：炎性和免疫调节性疾病，如哮喘，特应性皮炎，鼻炎，过敏性疾病，慢性阻塞性肺病（COPD），脓毒性休克，关节 疾病，自身免疫性疾病如类风湿性关节炎，格雷夫斯病，癌症，心肌收缩性疾病，心力衰竭，血栓栓塞，缺血和动脉粥样硬化。 本发明的化合物还可用于肺动脉高压，肾衰竭，心脏肥大，以及神经变性疾病如帕金森病，阿尔茨海默病，糖尿病和局灶性缺血，因为这些疾病还涉及人或动物中的PI3K活性 学科。

    Information Retrieving System
    20.
    发明申请
    Information Retrieving System 审中-公开
    信息检索系统

    公开(公告)号：US20090210411A1

    公开(公告)日：2009-08-20

    申请号：US12273556

    申请日：2008-11-19

    申请人： Toshiki Murata ,  Mihoko Kitamura ,  Tatsuya Sukehiro ,  Takeshi Yamamoto ,  Tadashi Fukushima ,  Sayori Shimohata ,  Atsushi Ikeno

    发明人： Toshiki Murata ,  Mihoko Kitamura ,  Tatsuya Sukehiro ,  Takeshi Yamamoto ,  Tadashi Fukushima ,  Sayori Shimohata ,  Atsushi Ikeno

    IPC分类号： G06F7/06 ,  G06F17/30 ,  G10L15/18

    CPC分类号： G10L15/1822 ,  G06F16/3334 ,  G10L15/26

    摘要： A user speech analyzing component poses, to a user, question sentences for respective ones of a plurality of attributes, and analyzes an attribute value for each of the attributes from an answer sentence from the user to the sentence question. A user data holding component, as a result of analysis, holds user data that allows the plurality of attributes, and respective user attribute values for the attributes to correspond to one another. A matching component, when an acquisition ratio of the attribute values from the user with respect to all of the attributes is a predetermined value or greater, selects at least one target data candidate that matches each of the attributes and each of the attribute values of the user data, from a plurality of target data. A dialogue control component outputs each of the target data candidates selected, to the user's side.

    摘要翻译： 用户语音分析组件向用户提供多个属性中的各个属性的问题句，并且从用户到句子问题的答案中分析每个属性的属性值。 作为分析的结果的用户数据保持组件保存允许多个属性的用户数据，并且用于属性的各个用户属性值彼此对应。 一种匹配部件，当来自用户的属性值相对于所有属性的获取比率为预定值或更大时，选择与每个属性值和每个属性值匹配的至少一个目标数据候选， 来自多个目标数据的用户数据。 对话控制部件向用户侧输出所选择的目标数据候补。