专利检索 ap:("UCB BIOPHARMA SRL") AND inv:"Daniel John Lightwood" 第 2 页

11.

发明授权
Antibody against trimeric TNFα complex 有权

公开(公告)号：US11174311B2

公开(公告)日：2021-11-16

申请号：US16470999

申请日：2017-12-13

申请人： UCB BIOPHARMA SRL , SANOFI

发明人： Alastair David Griffiths Lawson , Daniel John Lightwood , Rebecca Jayne Munro , James Philip O'Connell , John Robert Porter

IPC分类号： C07K16/24

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

12.

发明授权
Complexes between anti-TNF antibodies, trimeric TNF proteins and organic molecules binding them 有权

公开(公告)号：US10969393B2

公开(公告)日：2021-04-06

申请号：US15736535

申请日：2015-10-22

申请人： UCB Biopharma SRL

发明人： James Philip O'Connell , John Robert Porter , Alastair Lawson , Daniel John Lightwood , Rebecca Jayne Munro

IPC分类号： C07D401/14 , C07K14/525 , C07D471/00 , C07K14/705 , C07K16/24 , C07D213/72 , C07D235/04 , C07D239/26 , C07D471/04 , A61K47/64 , A61P37/00 , A61P35/00 , G01N33/68

摘要： It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.