公开(公告)号：US11174311B2

公开(公告)日：2021-11-16

申请号：US16470999

申请日：2017-12-13

Applicant: UCB BIOPHARMA SRL ,  SANOFI

Inventor： Alastair David Griffiths Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro ,  James Philip O'Connell ,  John Robert Porter

IPC: C07K16/24

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.

公开(公告)号：US10969393B2

公开(公告)日：2021-04-06

申请号：US15736535

申请日：2015-10-22

Applicant: UCB Biopharma SRL

Inventor： James Philip O'Connell ,  John Robert Porter ,  Alastair Lawson ,  Daniel John Lightwood ,  Rebecca Jayne Munro

IPC: C07D401/14 ,  C07K14/525 ,  C07D471/00 ,  C07K14/705 ,  C07K16/24 ,  C07D213/72 ,  C07D235/04 ,  C07D239/26 ,  C07D471/04 ,  A61K47/64 ,  A61P37/00 ,  A61P35/00 ,  G01N33/68

Abstract: It has been demonstrated that certain compounds bind to TNF and stabilise a conformation of trimeric TNF that binds to the TNF receptor. Antibodies which selectively bind to complexes of such compounds with TNF superfamily members are disclosed. These antibodies may be used to detect further compounds with the same activity, and as target engagement biomarker.