公开(公告)号：US20180353440A1

公开(公告)日：2018-12-13

申请号：US16004576

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghada

IPC: A61K31/047 ,  A61P17/02

CPC classification number: A61K31/047 ,  A61P17/02

Abstract: Methods and compositions are described for use in encouraging angiogenesis and skin healing as may be utilized in wound treatment as well as in encouragement of angiogenesis in disease. Compositions include an effective amount of a natural pimarane diterpenoid extract of Hymenocrater elegans, or a derivative, analogue, or homolog thereof. Compounds based upon this natural extract have been found to be highly effective in vascular formation and skin closure while exhibiting low toxicity.

公开(公告)号：US12196684B2

公开(公告)日：2025-01-14

申请号：US18323552

申请日：2023-05-25

Applicant: UNIVERSITY OF SOUTH CAROLINA

Inventor： Ehsan Jabbarzadeh ,  Sara Eslambolchimoghadam

IPC: G01N21/80 ,  A61B5/145

Abstract: Medical swabs incorporating a pH indicator in an absorbent crosslinked hydrogel matrix. The medical swabs can provide for visual monitoring of biological pH. The medical swabs can be used to monitor wounds, such as chronic wounds, burn wounds, surgical wounds, etc., as well as other biological fluids. The swabs can be used for early detection of chronic wounds and/or early detection of bacterial infections.

公开(公告)号：US10653638B2

公开(公告)日：2020-05-19

申请号：US16004538

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Wesley F. Taylor

IPC: A61K31/047 ,  A61K31/7072 ,  A61K45/06 ,  A61P35/00

Abstract: A pimarane diterpenoid, having the following structure: or a tautomer thereof in which R1 and R2 are independently selected from —H, C1-10 alkyl, C1-10 alkoxy, C1-10 alkenyl, C1-10 alkenoxy, —OH, —OAc, —CHO, -Ph, —OC6H5, —OC6H4OH, —COC6H5, —OCONH2, —OCONHCH3, —OCOC6H4NH2, —NH2, or ═O based on an isolate from the plant Hymenocrater elegans is utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The compound shows efficacy in treatment and prevention of a wide range of cancer types as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.

公开(公告)号：US20180353457A1

公开(公告)日：2018-12-13

申请号：US16004529

申请日：2018-06-11

Applicant: University of South Carolina

Inventor： Ehsan Jabbarzadeh ,  Wesley F. Taylor

IPC: A61K31/22 ,  A61K31/7072 ,  A61P35/00

CPC classification number: A61K31/22 ,  A61K31/7072 ,  A61P35/00

Abstract: Abietane diterpenoids developed from a 7-acetoxyroyleanone that has been isolated from the root of the plant Salvia leriifolia are utilized in the prevention of growth and development of pathogenic cells, e.g., cancer cells. The 7-acetoxyroyleanones show efficacy in treatment and prevention of a wide range of cancer types as well as other neoplastic diseases as a chemo-preventative, a primary or secondary cytotoxic agent, a sensitizer for other therapies, or one component of a combinatorial treatment.