公开(公告)号：US20190380761A1

公开(公告)日：2019-12-19

申请号：US16553479

申请日：2019-08-28

Applicant: University of Florida Research Foundation, Inc.

Inventor： John N. Catanzaro ,  Michele N. Dill ,  Christopher D. Batich

IPC: A61B18/00

Abstract: A flexible catheter is inserted into the esophagus to cool or warm the esophagus, particularly during certain procedures which can tend to change the temperature in the area of the esophagus. The catheter is inserted through the mouth and throat to a position, for example, proximate the heart, but within the esophagus. A thermally conductive gel is injected into the esophagus where it is immobilized by the one or more balloons. A coolant is pumped through a coolant tube affixed to the catheter, where it exchanges heat with the conductive gel.

公开(公告)号：US20190142003A1

公开(公告)日：2019-05-16

申请号：US16097934

申请日：2017-05-25

Applicant: Philip G. KOEHLER ,  Roberto M. PERERIA ,  Christopher D. BATICH ,  University of Florida Research Foundation, Inc.

Inventor： Philip G. Koehler ,  Roberto M. Pereira ,  Christopher D. Batich

IPC: A01N43/40 ,  A01N53/00

Abstract: Compositions, formulas, methods of making, mixing and applying insecticide formulations to different surfaces such as but not limited to interior surfaces of ovitraps, on walls and on chips and tiles to produce a texturized surface to allow for better transfer of the insecticidal active ingredients to insects, such as mosquitoes and the like, which land on or crawl on the surfaces, resulting in faster insect mortality rates. The texture of the insecticidal residue provides better transfer of the insecticidal active ingredients to insects that land on or crawl on the surface, resulting in faster insect mortality. The textured residue also enhances desirable surface characteristics for landing of mosquitoes and potentially other insects.

公开(公告)号：US20180017569A1

公开(公告)日：2018-01-18

申请号：US15665726

申请日：2017-08-01

Applicant: University of Florida Research Foundation, Inc.

Inventor： Richard J. Melker ,  Donn Michael Dennis ,  Christopher D. Batich ,  Mark S. Gold

IPC: G01N33/58 ,  A61B5/00 ,  A61K51/12 ,  A61K49/00 ,  A61B5/083

CPC classification number: G01N33/58 ,  A61B5/083 ,  A61B5/411 ,  A61B5/4833 ,  A61K49/0004 ,  A61K51/1206 ,  G01N2458/15 ,  Y10T436/22

Abstract: The present invention relates to the detection of markers in exhaled breath, wherein the detection of the presence or absence of the marker(s) in exhaled breath is used to assess various clinical data, including patient adherence in taking the medication and patient enzymatic (metabolic) competence in metabolizing the medication. An embodiment of the invention comprises a parent therapeutic agent labeled with a marker, where upon metabolism (e.g., via enzymatic action) of the therapeutic agent, the marker becomes volatile or semi-volatile and is present in the breath. In certain related embodiments, the marker contain a deuterium label, which is also present in the breath upon metabolism of the therapeutic agent. In another embodiment of the invention, the therapeutic agent is associated with a taggant (that may be either labeled or unlabeled with deuterium), which in turn will generate a marker in the breath that is easily measurable.