公开(公告)号：US08725259B2

公开(公告)日：2014-05-13

申请号：US13353861

申请日：2012-01-19

申请人： Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Xiaohong Zhou ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

发明人： Lilian Kornet ,  Richard N. M. Cornelussen ,  Paul D. Ziegler ,  Xiaohong Zhou ,  Eduardo Warman ,  Karen J. Kleckner ,  Lucy Nichols ,  Alberto Della Scala

IPC分类号： A61N1/365

CPC分类号： A61N1/36114

摘要： The disclosure herein relates generally to methods for treating heart conditions using vagal stimulation, and further to systems and devices for performing such treatment. Such methods may include monitoring physiological parameters of a patient, detecting cardiac conditions, and delivering vagal stimulation (e.g., electrical stimulation to the vagus nerve or neurons having parasympathetic function) to the patient to treat the detected cardiac conditions.

公开(公告)号：US08423134B2

公开(公告)日：2013-04-16

申请号：US13094392

申请日：2011-04-26

申请人： Hendrik Peter Johan Buschman ,  John Edward Burnes ,  Richard N. M. Cornelussen ,  Michael Roland Scott Hill ,  Lilian Kornet ,  Simone Cornelia Maria Anna Ordelman ,  Petrus Hermanus Veltink

发明人： Hendrik Peter Johan Buschman ,  John Edward Burnes ,  Richard N. M. Cornelussen ,  Michael Roland Scott Hill ,  Lilian Kornet ,  Simone Cornelia Maria Anna Ordelman ,  Petrus Hermanus Veltink

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/365

摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.

公开(公告)号：US08406868B2

公开(公告)日：2013-03-26

申请号：US13094231

申请日：2011-04-26

申请人： Hendrik Peter Johan Buschman ,  John Edward Burnes ,  Richard N. M. Cornelussen ,  Michael Roland Scott Hill ,  Lilian Kornet ,  Simone Cornelia Maria Anna Ordelman ,  Petrus Hermanus Veltink

发明人： Hendrik Peter Johan Buschman ,  John Edward Burnes ,  Richard N. M. Cornelussen ,  Michael Roland Scott Hill ,  Lilian Kornet ,  Simone Cornelia Maria Anna Ordelman ,  Petrus Hermanus Veltink

IPC分类号： A61N1/00

CPC分类号： A61N1/36114 ,  A61N1/365

摘要： Methods for treating a patient and further to devices for performing such treatment, e.g., methods and devices to perturb at least one physiological system and deliver therapy to the patient based on the effects of such perturbation. For example, a method for using an implantable medical device is disclosed that involves delivering electrical stimuli to an efferent nerve associated with the selected organ. Afferent electrical activity is monitored during delivery of electrical stimuli to the efferent nerve, the monitored afferent electrical activity includes an indirect component of a compound action potential (CAP). A status of the selected organ is assessed based upon the indirect component. A determination is made as to whether to deliver therapy to the selected organ in response to assessing the status of the selected organ.

摘要翻译： 用于治疗患者和进一步进行这种治疗的装置的方法，例如用于扰乱至少一个生理系统的方法和装置，并且基于这种扰动的影响向患者递送治疗。 例如，公开了一种使用可植入医疗装置的方法，其涉及将电刺激递送至与选定器官相关的传出神经。 在传递电刺激到传出神经时监测传入的电活动，所监测的传入电活动包括复合动作电位（CAP）的间接成分。 所选器官的状态根据间接成分进行评估。 根据评估所选器官的状态，确定是否对所选择的器官进行治疗。