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47 条记录 (耗时 0.027 秒)

    4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    11.
    发明授权
    4-(phenyl-(piperidin-4-yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07226933B2

    公开(公告)日：2007-06-05

    申请号：US10477852

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06 ,  Y02P20/55

    摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, pyrrolyl, thienyl, furanyl, imidazolyl, triazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as their pharmaceutically acceptable salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式I R 1的化合物选自苯基，吡啶基，吡咯基，噻吩基，呋喃基，咪唑基，三唑基和吡啶N-氧化物中的任一种; 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及它们的药学上可接受的盐和药物组合物，其包含新化合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠疾病中的用途。

    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    12.
    发明授权
    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07008952B2

    公开(公告)日：2006-03-07

    申请号：US10477636

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： A61K31/55 ,  C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula I[Chemical formula should be inserted here. Please see paper copy] R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式Ⅰ化合物[化学式应在此插入。 R 1选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种。 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。

    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders
    14.
    发明授权
    4-(phenyl-(piperidin-4yl)-amino)-benzamide derivatives and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07186733B2

    公开(公告)日：2007-03-06

    申请号：US10477633

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： A61K31/4468 ,  C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula I R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl, and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6alkyl, NO2, CF3, C1–C6alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety or functional gastrointestinal disorders.

    摘要翻译： 通式I R 1的化合物选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任一种; 其中每个R 1苯基环和R 1个杂芳族环可以任选和独立地被1,2或3个选自直链和支链C 1〜 C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑或功能性胃肠道疾病中的用途。

    4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivaties and their use for the treatment of pain, anxiety or gastrointestinal disorders
    19.
    发明授权
    4-(Phenyl-(piperidin-4-yl)-amino)-benzamide derivaties and their use for the treatment of pain, anxiety or gastrointestinal disorders 失效
    4-（苯基 - （哌啶-4-基） - 氨基） - 苯甲酰胺衍生物及其用于治疗疼痛，焦虑或胃肠道疾病

    公开(公告)号：US07064137B2

    公开(公告)日：2006-06-20

    申请号：US10477853

    申请日：2002-05-16

    申请人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    发明人： William Brown ,  Andrew Griffin ,  Christopher Walpole

    IPC分类号： A61K31/4468 ,  C07D211/58

    CPC分类号： C07D401/06 ,  C07D211/58 ,  C07D405/06 ,  C07D409/06 ,  C07D417/06

    摘要： Compounds of general formula (I): R1 is selected from any one of phenyl, pyridinyl, thienyl, furanyl, imidazolyl, pyrrolyl, triazolyl, thiazolyl and pyridine N-oxide; where each R1 phenyl ring and R1 heteroaromatic ring may optionally and independently be further substituted by 1, 2 or 3 substituents selected from straight and branched C1–C6 alkyl, NO2, CF3, C1–C6 alkoxy, chloro, fluoro, bromo, and iodo. The substitutions on the phenyl ring and on the heteroaromatic ring may take place in any position on said ring systems; are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain, anxiety and functional gastrointestinal disorders.

    摘要翻译： 通式（I）的化合物：R 1选自苯基，吡啶基，噻吩基，呋喃基，咪唑基，吡咯基，三唑基，噻唑基和吡啶N-氧化物中的任何一种; 其中每个R 1苯基环和R 1'杂芳环可以任选地和独立地被1,2或3个选自直链和支链C 1的取代基取代， C 1 -C 6烷基，NO 2，CF 3，C 1 -C 6烷基，C 1 -C 6烷基， 烷氧基，氯，氟，溴和碘。 苯环上和杂芳环上的取代可以在所述环体系上的任何位置进行; 在本申请中公开和要求保护，以及包含新化合物的盐和药物组合物及其在治疗中的用途，特别是在治疗疼痛，焦虑和功能性胃肠道疾病中的用途。