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公开(公告)号：US20110105464A1
公开(公告)日：2011-05-05
申请号：US12916125
申请日：2010-10-29
申请人： Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson , Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss
发明人： Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel P. Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson , Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss
CPC分类号： C07D491/04 , C07D495/04
摘要： Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20080076768A1
公开(公告)日：2008-03-27
申请号：US11789423
申请日：2007-04-24
IPC分类号： A61K31/5355 , A61P29/00 , A61P3/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P5/00 , A61P9/00 , C07D413/14
CPC分类号： A61K31/5355 , C07D495/04
摘要： A thienopyrimidine of formula (I): and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K with selectivity for the P110α subtype, and may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour, particularly those associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
摘要翻译： 式（I）的噻吩并嘧啶及其药学上可接受的盐具有作为P110α亚型选择性的PI3K抑制剂的活性，并且可用于治疗由异常细胞生长，功能或行为引起的疾病和障碍，特别是与 PI3激酶如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌障碍和神经障碍。 还描述了合成化合物的方法。
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公开(公告)号：US20080076758A1
公开(公告)日：2008-03-27
申请号：US11789468
申请日：2007-04-24
申请人： Adrian Folkes , Stephen Shuttleworth , Irina Chuckowree , Sally Oxenford , Nan Chi Wan , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Simon Mathieu , Alan Olivero , Daniel Sutherlin , Bing-Yan Zhu
发明人： Adrian Folkes , Stephen Shuttleworth , Irina Chuckowree , Sally Oxenford , Nan Chi Wan , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Simon Mathieu , Alan Olivero , Daniel Sutherlin , Bing-Yan Zhu
IPC分类号： A61K31/5377 , A61K31/551 , A61P25/00 , A61P29/00 , A61P3/00 , A61P31/00 , A61P35/00 , A61P37/00 , A61P9/00 , C07D491/048 , C07D495/04
CPC分类号： A61K31/5377 , A61K31/551 , A61K45/06 , C07D491/04 , C07D491/048 , C07D495/04
摘要： Compounds of Formulae Ia and Ib, and stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物及其立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US20080039459A1
公开(公告)日：2008-02-14
申请号：US11789427
申请日：2007-04-24
申请人： Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson
发明人： Adrian Folkes , Stephen Shuttleworth , Sally Oxenford , Tim Hancox , Tracy Bayliss , Georgette Castanedo , Richard Goldsmith , Janet Gunzner , Tim Heffron , Kimberly Malesky , Simon Mathieu , Alan Olivero , Daniel Sutherlin , Vickie Tsui , Shumei Wang , Christian Wiesmann , Bing-Yan Zhu , Jennafer Dotson
IPC分类号： C07D413/14 , A61K31/5377 , A61P17/00 , A61P25/00 , A61P3/00 , A61P3/10 , C12N9/99 , A61P31/00 , A61P35/00 , A61P41/00 , A61P9/00
CPC分类号： C07D491/04 , C07D495/04
摘要： Compounds of Formulas Ia and Ib, and including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting lipid kinases including PI3K, and for treating disorders such as cancer mediated by lipid kinases. Methods of using compounds of Formula Ia and Ib for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.
摘要翻译： 式Ia和Ib的化合物，并且包括立体异构体，几何异构体，互变异构体，溶剂合物，代谢物和药学上可接受的盐可用于抑制脂质激酶（包括PI3K）和用于治疗由脂质激酶介导的癌症等疾病。 公开了将式Ia和Ib化合物用于体外，原位和体内诊断，预防或治疗哺乳动物细胞或相关病理状况中的这种病症的方法。
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公开(公告)号：US5707548A
公开(公告)日：1998-01-13
申请号：US507331
申请日：1995-10-06
CPC分类号： C09K11/02 , C09K11/7705 , C09K11/7773 , G21K4/00 , G21K2004/08
摘要： A storage phosphor material comprising a storage phosphor of the kind in which electrons excited by incident ionizing radiation may be trapped in stable trap sites and subsequently released by stimulation such as photostimulation, wherein the phosphor is contained within a host matrix which comprises a sol-gel glass in which the storage phosphor is incorporated as a dopant.
摘要翻译： PCT No.PCT / GB94 / 02833 Sec。 371日期1995年10月6日 102（e）日期1995年10月6日PCT 1994年12月21日PCT PCT。 WO95 / 18176 PCT出版物 日期1995年7月6日一种存储磷光体材料，其包括这样的存储磷光体，其中由入射电离辐射激发的电子可以被捕获在稳定的捕获位点中，并随后通过诸如光刺激的刺激释放，其中磷光体包含在主体基质内 包括其中掺入存储磷光体作为掺杂剂的溶胶 - 凝胶玻璃。
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公开(公告)号：US08324206B2
公开(公告)日：2012-12-04
申请号：US12840070
申请日：2010-07-20
IPC分类号： A61K31/535
CPC分类号： A61K31/5355 , C07D495/04
摘要： A thienopyrimidine of formula (I): and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K with selectivity for the P110α subtype, and may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour, particularly those associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
摘要翻译： 式（I）的噻吩并嘧啶及其药学上可接受的盐具有作为P110α亚型选择性的PI3K抑制剂的活性，并且可用于治疗由异常细胞生长，功能或行为引起的疾病和障碍，特别是与 PI3激酶如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌障碍和神经障碍。 还描述了合成化合物的方法。
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公开(公告)号：US07781433B2
公开(公告)日：2010-08-24
申请号：US11789423
申请日：2007-04-24
IPC分类号： A61K31/535 , C07D413/14
CPC分类号： A61K31/5355 , C07D495/04
摘要： A thienopyrimidine of formula (I): and the pharmaceutically acceptable salts thereof have activity as inhibitors of PI3K with selectivity for the P110α subtype, and may be used to treat diseases and disorders arising from abnormal cell growth, function or behaviour, particularly those associated with PI3 kinase such as cancer, immune disorders, cardiovascular disease, viral infection, inflammation, metabolism/endocrine disorders and neurological disorders. Processes for synthesizing the compounds are also described.
摘要翻译： 式（I）的噻吩并嘧啶及其药学上可接受的盐具有作为P110α亚型选择性的PI3K抑制剂的活性，并且可用于治疗由异常细胞生长，功能或行为引起的疾病和障碍，特别是与 PI3激酶如癌症，免疫疾病，心血管疾病，病毒感染，炎症，代谢/内分泌障碍和神经障碍。 还描述了合成化合物的方法。
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18.发明申请Compounds, pharmaceutical compositions and methods for use in treating metabolic disorders 有权用于治疗代谢紊乱的化合物，药物组合物和方法公开(公告)号：US20060004012A1
公开(公告)日：2006-01-05
申请号：US11067377
申请日：2005-02-25
申请人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jiwen Liu , Jian Luo , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
发明人： Michelle Akerman , Jonathan Houze , Daniel Lin , Jiwen Liu , Jian Luo , Julio Medina , Wei Qiu , Jeffrey Reagan , Rajiv Sharma , Michael Schmitt , Stephen Shuttleworth , Ying Sun , Yingcai Wang , Jian Zhang , Liusheng Zhu
IPC分类号： A61K31/498 , C07D43/02
CPC分类号： C07D277/24 , C07D277/30
摘要： The present invention provides compounds useful, for example, for modulating insulin levels in a subject and that have the general formula Q-L1-P-L2-M-X-L3-A wherein the definitions of the variables Q, L1, P, L2, M, X, L3 and A are provided herein. The present invention also provides compositions and methods for use of the compounds, for instance, for treatment of type II diabetes.
摘要翻译： 本发明提供了可用于例如调节受试者中的胰岛素水平的化合物，并且具有通式<？in-line-formula description =“In-line formula”end =“lead”→> QL < -PL 2 3 -A <？in-line-formula description =“In-line Formulas”end =“tail”？>其中 本文提供变量Q，L 1，P，L 2，M，X，L 3和A的定义。 本发明还提供了用于治疗II型糖尿病的化合物的组合物和方法。
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