公开(公告)号：US20210139461A1

公开(公告)日：2021-05-13

申请号：US16605944

申请日：2018-04-18

申请人： Yuhan Corporation

发明人： Sang Ho OH ,  Jong Gyun KIM ,  Se-Woong OH ,  Tae Dong HAN ,  Soo Yong CHUNG ,  Seong Ran LEE ,  Kyeong Bae KIM ,  Young Sung LEE ,  Woo Seob SHIN ,  Hyun JU ,  Jeong Ki KANG ,  Su Min PARK ,  Dong Kyun KIM

IPC分类号： C07D403/04 ,  C07C309/04 ,  C07C303/22

摘要： The present invention relates to novel mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yppyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, a novel crystalline form thereof, and a process for preparing the same. More specifically, the present invention relates to mesylate salt of N-(5-(4-(4-((dimethylamino)methyl)-3-phenyl-1H-pyrazol-1-yl)pyrimidine-2-ylamino)-4-methoxy-2-morpholinophenyl)acrylamide, which is excellent in stability, solubility, and bioavailability when it is administered not only alone but also in combination with other drugs and which has a high purity, a crystalline form thereof, and a process for preparing the same.