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44 条记录 (耗时 0.053 秒)

    FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF
    11.
    发明申请
    FUSED PYRAZOLE DERIVATIVES AND METHODS OF TREATMENT OF METABOLIC-RELATED DISORDERS THEREOF 审中-公开
    熔化的吡唑衍生物及其代谢相关疾病的治疗方法

    公开(公告)号：US20090258892A1

    公开(公告)日：2009-10-15

    申请号：US12433704

    申请日：2009-04-30

    申请人： P. Douglas Boatman ,  Thomas O. Schrader ,  Graeme Semple ,  Philip J. Skinner ,  Jae-Kyu Jung

    发明人： P. Douglas Boatman ,  Thomas O. Schrader ,  Graeme Semple ,  Philip J. Skinner ,  Jae-Kyu Jung

    IPC分类号： A61K31/437 ,  C07D231/54 ,  C07D403/04 ,  A61K31/416 ,  A61K31/41 ,  A61K31/40

    CPC分类号： C07D403/04 ,  C07D209/80 ,  C07D209/88 ,  C07D231/54 ,  C07D265/36 ,  C07D471/04 ,  C07D471/14

    摘要： The present invention relates to certain fused pyrazole derivatives of Formula (Ia), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers, DP receptor antagonists, and the like.

    摘要翻译： 本发明涉及式（Ia）的某些稠合吡唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病的方法 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂，DP受体拮抗剂等。

    5-Substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the acid receptor rup25 for the treatment of dyslipidemia and related diseases
    13.
    发明申请
    5-Substituted 2h-pyrazole-3-carboxylic acid derivatives as agonists for the acid receptor rup25 for the treatment of dyslipidemia and related diseases 审中-公开
    5-取代的2h-吡唑-3-羧酸衍生物作为用于治疗血脂异常和相关疾病的酸受体rup25的激动剂

    公开(公告)号：US20070032537A1

    公开(公告)日：2007-02-08

    申请号：US10560332

    申请日：2004-06-10

    申请人： Graeme Semple ,  Tawfik Gharbaoui ,  Young-Jun Shin ,  Marc Decaire ,  Claudia Averbuj ,  Philip Skinner

    发明人： Graeme Semple ,  Tawfik Gharbaoui ,  Young-Jun Shin ,  Marc Decaire ,  Claudia Averbuj ,  Philip Skinner

    IPC分类号： A61K31/4152 ,  C07D231/02

    CPC分类号： C07D231/14 ,  A61K31/415 ,  A61K45/06 ,  A61K2300/00

    摘要： The present invention relates to certain pyrazole carboxylic acid and ester derivatives, and pharmaceutically acceptable salts thereof, which exhibit useful pharmaceutical properties, for example as agonists for the RUP25 receptor. (I) Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like the substituents are defined in claim 1.

    摘要翻译： 本发明涉及表现出有用的药物性质的某些吡唑羧酸和酯衍生物及其药学上可接受的盐，例如作为RUP25受体的激动剂。 （I）本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素 抗性，2型糖尿病，综合征等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等，取代基如权利要求1中所定义。

    Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof
    14.
    发明申请
    Tetrazole derivatives and methods of treatment of metabolic-related disorders thereof 失效
    四唑衍生物及其代谢相关病症的治疗方法

    公开(公告)号：US20060217562A1

    公开(公告)日：2006-09-28

    申请号：US10535345

    申请日：2004-10-29

    申请人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

    发明人： Graeme Semple ,  Thomas Schrader ,  Philip Skinner ,  Steven Colletti ,  Tawfik Gharbaoui ,  Jason Imbriglio ,  Jae-Kyu Jung ,  Rui Liang ,  Subharekha Raghavan ,  Darby Schmidt ,  James Tata

    IPC分类号： A61K31/416 ,  C07D403/02

    CPC分类号： C07D491/04 ,  C07D403/04 ,  C07D495/04

    摘要： The present invention relates to certain tetrazole derivatives of Formula (I), and pharmaceutically acceptable salts thereof, which exhibit useful pharmacological properties, for example, as agonists for the RUP25 receptor. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of α-glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

    摘要翻译： 本发明涉及式（I）的某些四唑衍生物及其药学上可接受的盐，其表现出有用的药理学性质，例如作为RUP25受体的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物治疗代谢相关疾病包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，2型糖尿病的方法 ，综合征-X等。 此外，本发明还提供本发明化合物与其它活性剂如属于α-葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成 抑制剂，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。

    Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof
    15.
    发明申请
    Benzotriazoles and methods of prophylaxis or treatment of metabolic-related disorders thereof 审中-公开
    苯并三唑及其代谢相关疾病的预防或治疗方法

    公开(公告)号：US20060122240A1

    公开(公告)日：2006-06-08

    申请号：US10533799

    申请日：2003-11-04

    申请人： Graeme Semple ,  Philip Skinner ,  Martin Cherrier ,  Peter Webb ,  Susan Tamura

    发明人： Graeme Semple ,  Philip Skinner ,  Martin Cherrier ,  Peter Webb ,  Susan Tamura

    IPC分类号： C07D249/16 ,  A61K31/4192

    CPC分类号： C07D405/06 ,  A61K31/4192 ,  C07D249/18

    摘要： The present invention relates to certain benzotriazole carboxylic acid or ester derivatives of Formula (I), pharmaceutically acceptable salts and solvates thereof, which exhibit useful pharmaceutical properties, for example, as agonists for the GPCR referred to as hRUP38. Also provided by the present invention are pharmaceutical compositions containing compounds of the invention, and methods of using the compounds and compositions of the invention in the prophylaxis or treatment of metabolic-related disorders, including dyslipidemia, atherosclerosis, coronary heart disease, insulin resistance, type 2 diabetes, Syndrome-X and the like. In addition, the present invention also provides for the use of the compounds of the invention in combination with other active agents such as those belonging to the class of -glucosidase inhibitors, aldose reductase inhibitors, biguanides, HMG-CoA reductase inhibitors, squalene synthesis inhibitors, fibrates, LDL catabolism enhancers, angiotensin converting enzyme (ACE) inhibitors, insulin secretion enhancers and the like.

    摘要翻译： 本发明涉及一些表现出有用的药物性质的式（I）的苯并三唑羧酸或酯衍生物，其药学上可接受的盐和溶剂化物，例如被称为hRUP38的GPCR的激动剂。 本发明还提供含有本发明化合物的药物组合物，以及使用本发明化合物和组合物预防或治疗代谢相关疾病（包括血脂异常，动脉粥样硬化，冠心病，胰岛素抵抗，类型 2型糖尿病，综合征X等。 此外，本发明还提供本发明化合物与其它活性剂如属于葡糖苷酶抑制剂类，醛糖还原酶抑制剂，双胍类，HMG-CoA还原酶抑制剂，角鲨烯合成抑制剂 ，贝特类，LDL分解代谢增强剂，血管紧张素转换酶（ACE）抑制剂，胰岛素分泌增强剂等。