公开(公告)号：US06424866B1

公开(公告)日：2002-07-23

申请号：US09841891

申请日：2001-04-25

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Yoav Kimchy

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Yoav Kimchy

IPC分类号： A61N136

摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart are disclosed. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrilation signals to the heart.

公开(公告)号：US20080188837A1

公开(公告)日：2008-08-07

申请号：US11792881

申请日：2005-12-14

申请人： Ziv Belsky ,  Marina Tsad-Kin-Tamir

发明人： Ziv Belsky ,  Marina Tsad-Kin-Tamir

IPC分类号： A61K9/22

CPC分类号： A61K9/48 ,  A61B5/4839 ,  A61K9/0053 ,  A61K9/0097 ,  A61M31/002

摘要： An apparatus is provided for use in conjunction with a drug delivered to a gastrointestinal (GI) tract of a subject. The apparatus includes an ingestible capsule, which includes one or more electrodes, and a control component, adapted to drive the electrodes to apply an electrical current that induces local delivery of the drug in target tissue of the GI tract. Additional embodiments are also described.

摘要翻译： 提供一种与输送到受试者的胃肠（GI）道的药物结合使用的装置。 该装置包括可摄入胶囊，其包括一个或多个电极，以及控制部件，其适于驱动电极以施加电流，该电流引起药物在胃肠道的靶组织中的局部递送。 还描述了另外的实施例。

公开(公告)号：US07027863B1

公开(公告)日：2006-04-11

申请号：US10111516

申请日：2000-10-25

申请人： David Prutchi ,  Nissim Darvish ,  Andre G. Routh ,  Edward Haluska ,  Ziv Belsky

发明人： David Prutchi ,  Nissim Darvish ,  Andre G. Routh ,  Edward Haluska ,  Ziv Belsky

IPC分类号： A61N1/39

CPC分类号： A61N1/39 ,  A61N1/3621 ,  A61N1/3627 ,  A61N1/3962

摘要： A multi-modal cardiotherapy device (100) includes an anti-arrhythmic unit (118) for delivering multiple types of anti-arrhythmic therapy to a heart, a cardiac contractility modulating unit (108) for delivering cardiac contractility modulating signals to the heart, and for applying anti-arrhythmic cardiac contractility modulating signal therapy to the heart, one or more sensing units (112) for sensing electrical signals related to electrical activity of the heart to provide an output signal, one or more detecting units (116) operatively connected to the sensing unit(s) (112) for detecting in the output signal cardiac events of the heart, a controller unit (106) operatively connected to the anti-arrhythmic unit (118), the cardiac contractility modulating unit (108) and the detecting unit(s) (116). The controller unit (106) processes the output of the detecting unit(s) (116) to detect a cardiac arrhythmia or indications of a possible arrhythmia in the heart and controls the application of anti-arrhythmic therapy, anti-arrhythmic cardiac contractility modulating signal therapy, and cardiac contractility modulating therapy to the heart. The device may be an implantable device or a non-implantable device. The device (100) may also include a pacing unit (102). Methods are disclosed for using the device for delivering multi-modal cardiotherapy to the heart.

摘要翻译： 多模式心脏治疗装置（100）包括用于向心脏递送多种类型的抗心律失常治疗的抗心律不齐装置（118），用于将心脏收缩调节信号输送到心脏的心脏收缩力调节单元（108），以及 用于向心脏施加抗心律失常心脏收缩调节信号治疗的一个或多个感测单元（112），用于感测与心脏的电活动相关的电信号以提供输出信号;一个或多个检测单元（116），其可操作地连接到 用于在输出信号中检测心脏心脏事件的感测单元（112），可操作地连接到抗心律失调单元（118）的心脏收缩力调节单元（108）和检测器 单位（116）。 控制器单元（106）处理检测单元（116）的输出以检测心脏心律失常或心脏中可能的心律不齐的指征，并控制抗心律不齐治疗，抗心律失常心肌收缩调节信号的应用 治疗和心脏收缩力调节治疗心脏。 该装置可以是可植入装置或非植入装置。 设备（100）还可以包括起搏单元（102）。 公开了使用用于向心脏递送多模式心脏治疗的装置的方法。

公开(公告)号：US06993391B2

公开(公告)日：2006-01-31

申请号：US10446567

申请日：2003-05-28

申请人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

发明人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

IPC分类号： A61N1/18

CPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/306 ,  A61N1/326 ,  A61N1/36007

摘要： Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross-sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

公开(公告)号：US06600953B2

公开(公告)日：2003-07-29

申请号：US09734358

申请日：2000-12-11

申请人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

发明人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

IPC分类号： A61N136

CPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/306 ,  A61N1/326 ,  A61N1/36007

摘要： Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross-sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

公开(公告)号：US06263242B1

公开(公告)日：2001-07-17

申请号：US09276460

申请日：1999-03-25

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky

IPC分类号： A61N136

CPC分类号： A61N1/3627 ,  A61B5/0452 ,  A61N1/368 ,  A61N1/3962

摘要： A method and devices for timing the delivery of non-excitatory signals for modifying myocardial contractility of a portion of the heart. The method includes the steps of applying electrodes to a plurality of cardiac sites, sensing electrical activity in a first cardiac site through a first electrode for detecting a first electrical depolarization event within a beat cycle, sensing electrical activity in a second cardiac site through a second electrode for detecting a second electrical depolarization event within the beat cycle, and applying a non-excitatory signal to the heart at or near at least the second cardiac site through at least one of the electrodes in response to detecting the second electrical depolarization event within an alert window period. The alert window period starts at a first delay from the time of detection of the first electrical depolarization event and has a first duration. The applying of the non-excitatory signal is delayed from the time of detecting of the second electrical depolarization event. The method may include steps for reducing the probability of delivering of improperly timed non-excitatory signals due to electrical noise and/or ectopic beats and may also include steps for preventing delivery of multiple non-excitatory signals at or near the second cardiac site within a single cardiac beat cycle. Preferably, the first cardiac site is located about the right ventricle or the right atrium of the heart and the second cardiac site is located about the left ventricle of the heart. The devices may also be adapted for pacing the heart and/or for delivering defibrillation signals to the heart.

摘要翻译： 用于定时递送非兴奋性信号以改善心脏部分心肌收缩力的方法和装置。 该方法包括以下步骤：将电极施加到多个心脏部位，通过第一电极感测第一心脏位点中的电活动，以检测搏动周期内的第一电去极化事件，通过第二电极感测第二心脏位点中的电活动 电极，用于检测所述拍摄周期内的第二电去极化事件，以及响应于检测到所述第二电去极化事件中的至少一个所述电极中的至少第二心脏位点处或附近的心脏施加非兴奋性信号 警报窗口期间。 警报窗口期间从检测到第一电去极化事件的时间开始，并且具有第一持续时间。 从第二次电去极化事件的检测时间开始延迟非兴奋性信号的施加。 该方法可以包括用于降低由于电噪声和/或异位搏动而递送不正确定时的非兴奋性信号的可能性的步骤，并且还可以包括用于防止在第一心脏位点处或附近传递多个非兴奋性信号的步骤 单心跳搏动循环。 优选地，第一心脏位点位于心脏的右心室或右心房周围，并且第二心脏部位位于心脏的左心室周围。 所述装置还可以适于起搏心脏和/或用于将除颤信号输送到心脏。

公开(公告)号：US06233487B1

公开(公告)日：2001-05-15

申请号：US09338649

申请日：1999-06-23

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61N1362

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3622 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： A method for setting the parameters of an alert time window in an excitable tissue control device operative under a plurality of different cardiac conditions of a heart of a patient. The method includes providing said excitable tissue control device with a set of data including a plurality of sets of alert time window parameters. Each set of window parameters is uniquely associated with a different set of values of a plurality of cardiac condition defining parameters identifying one of the different cardiac conditions. Each set of window parameters includes at least a set of timing parameters usable for obtaining a beginning time point and an ending time point of the alert window. The sets of window parameters are obtained by processing data collected within a data collection session from a plurality of cardiac beats of the same patient under the different cardiac conditions. The methods updates for each current beat cycle the values of a plurality of cardiac condition defining variables corresponding to said cardiac condition defining parameters, automatically selects a current set of alert time window parameters based on the current values of the cardiac condition defining variables, starts and terminates the alert time window based on the time of detecting a first depolarization event at a first cardiac site, detects within the duration of the alert window a second depolarization event at a second cardiac site, and triggers the delivery of a delayed non-excitatory excitable tissue control signal at the second cardiac site based on the time of detection of the second depolarization event. The different cardiac conditions include different beat cycle lengths, and may include beats which are or are not influenced by prior application of ETC signals to the heart and, where relevant, naturally and artificially paced beats. The alert window parameters may include an event detection sensitivity level parameter. Implantable and external devices are describe which are adapted for implementing the disclosed method.

公开(公告)号：US06223072B1

公开(公告)日：2001-04-24

申请号：US09328068

申请日：1999-06-08

申请人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

发明人： Yuval Mika ,  David Prutchi ,  Ziv Belsky ,  Andre G. Routh

IPC分类号： A61B50456

CPC分类号： A61B5/0402 ,  A61B5/7203 ,  A61N1/3627 ,  A61N1/3962 ,  H01L21/568 ,  H01L21/6835 ,  H01L23/3107 ,  H01L2924/0002 ,  H01L2924/00

摘要： Apparatus and method for obtaining from a patient's heart data useful for on-line setting of the parameters of a detection time window in an excitable tissue control device. The method includes applying electrodes to a first cardiac site and a second cardiac site of a patient and electrically connecting the electrodes to a data collecting device. The device is then operated under a plurality of different cardiac conditions to obtain a plurality of different histogram data sets. Each histogram data set represents a cumulative time distribution histogram of cardiac depolarization events detected at the second cardiac site in a plurality of cardiac beats. Each histogram data set is defined by a plurality of histogram parameters having values indicative of the cardiac conditions common to the plurality of cardiac beats used to obtain the histogram data set. The histogram parameters include a sensitivity level parameter representing the sensitivity level used for detecting the cardiac depolarization events of the plurality of cardiac beats at the second cardiac site. Another histogram parameter represents the range of values of the beat to beat time interval for the beats who's data is included in the histogram data set. Another histogram parameter has values indicating if the beats who's data is included in the histogram data set were acquired under conditions in which the delivery of non-excitatory ETC signals substantially affected or did not substantially affect the velocity of propagation of depolarization waves in the myocardium. Another histogram parameter, which may be used in devices having pacing capability has values indicating whether the beats who's data is included in the histogram data set are paced beats or non-paced beats. The histogram data sets are processed for computing a set of data usable for on-line setting of the parameters of a detection time window. This set of data may then be used for operating an implanted or external ETC device operatively connected to the electrodes.

公开(公告)号：US07512442B2

公开(公告)日：2009-03-31

申请号：US11260971

申请日：2005-10-28

申请人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

发明人： Melina Flesler ,  Yuval Mika ,  Ziv Belsky ,  Yaakov Ben Arie ,  Nissim Darvish ,  Shlomo Ben-Haim

IPC分类号： A61N1/36

CPC分类号： A61N1/05 ,  A61N1/08 ,  A61N1/306 ,  A61N1/326 ,  A61N1/36007

摘要： Apparatus is provided for treating a condition such as obesity. The apparatus includes a set of one or more electrodes, which are adapted to be applied to one or more respective sites in a vicinity of a body of a stomach of a patient. A control unit is adapted to drive the electrode set to apply to the body of the stomach a signal, configured such that application thereof increases a level of contraction of muscle tissue of the body of the stomach, and decreases a cross sectional area of a portion of the body of the stomach for a substantially continuous period greater than about 3 seconds.

摘要翻译： 提供用于治疗诸如肥胖症的病症的装置。 该装置包括一组一个或多个电极，其适于施加到患者的胃的身体附近的一个或多个相应部位。 控制单元适于驱动电极组以向胃体施加信号，该信号被配置为使得其应用增加胃体的肌肉组织的收缩水平，并且减小部分的横截面面积 的胃大体连续的时间大于约3秒。

公开(公告)号：US20080275430A1

公开(公告)日：2008-11-06

申请号：US11792270

申请日：2005-12-14

申请人： Ziv Belsky ,  Shahar Peled

发明人： Ziv Belsky ,  Shahar Peled

IPC分类号： A61K9/22

CPC分类号： A61K9/48 ,  A61B5/4839 ,  A61K9/0053 ,  A61K9/0097 ,  A61M31/002

摘要： Apparatus is provided for drug administration. The apparatus includes an ingestible capsule, which includes a drug, stored by the capsule. The apparatus also includes an environmentally-sensitive mechanism, adapted to change a state thereof responsively to a disposition of the capsule within a gastrointestinal (GI) tract of a subject; one or more drug-passage facilitation electrodes; and a control component, adapted to facilitate passage of the drug, in response to a change of state of the environmentally-sensitive mechanism, by driving the drug-passage facilitation electrodes to apply an electrical current. The apparatus further includes a velocity-reduction element adapted to reduce a velocity of the capsule through the GI tract for at least a portion of the time that the control component is facilitating the passage of the drug. Additional embodiments are also described.

摘要翻译： 提供用于药物给药的装置。 该装置包括可吸收胶囊，其包含由胶囊储存的药物。 该装置还包括环境敏感的机构，其适于根据受试者的胃肠（GI）管道内的胶囊的配置来改变其状态; 一个或多个药物通道促进电极; 以及控制部件，其适于响应于环境敏感性机构的状态的改变而促进药物的通过，通过驱动药物通道促进电极以施加电流。 该装置还包括速度减小元件，其适于在控制组件促进药物通过的至少一部分时间内减小胶囊通过胃肠道的速度。 还描述了另外的实施例。