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公开(公告)号:US09145392B2
公开(公告)日:2015-09-29
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Yufang Xiao , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Yufang Xiao , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/4545 , A61K31/506 , A61K31/5377 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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12.Novel Imidazol-piperidinyl Derivatives as Modulators of Kinase Activity 有权
标题翻译: 新型咪唑 - 哌啶衍生物作为激酶活性的调节剂公开(公告)号:US20150239902A1
公开(公告)日:2015-08-27
申请号:US14432319
申请日:2013-11-15
申请人: Ruoxi LAN , Bayard R. HUCK , Xiaoling CHEN , Yufang XIAO , MERCK PATENT GMBH
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao
IPC分类号: C07D498/04 , C07D487/04 , A61K31/519 , A61K45/06 , A61K31/517 , C07D471/04 , A61K31/4375 , A61K31/5383 , C07D401/14
CPC分类号: C07D498/04 , A61K31/4375 , A61K31/517 , A61K31/519 , A61K31/5383 , A61K45/06 , C07D239/70 , C07D401/14 , C07D471/04 , C07D487/04
摘要: The invention provides novel imidazol-piperidinyl derivatives of formula (I) in which R1, R2, X1, X2, X3, X4 and n have the meanings indicated in above, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I)的新型咪唑 - 哌啶基衍生物,其中R1,R2,X1,X2,X3,X4和n具有上述含义,以及它们用于治疗过度增殖性疾病如癌症的制备和用途 。
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公开(公告)号:US08946247B2
公开(公告)日:2015-02-03
申请号:US13989199
申请日:2011-11-11
申请人: Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
发明人: Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
IPC分类号: A61K31/517 , C07D239/72
CPC分类号: C07D403/12 , A61K31/517 , A61K45/06
摘要: The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型喹唑啉羧酰胺氮杂环丁烷化合物和用于治疗过度增殖性疾病如癌症的用途。
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公开(公告)号:US20140343029A1
公开(公告)日:2014-11-20
申请号:US14237075
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao , Lizbeth Celeste Deselm , Hui Qiu , Constantin Neagu , Donald Bankston , Christopher Charles Victor Jones
IPC分类号: C07D401/14 , A61K31/506 , C07D413/14 , C07D491/107 , C07D409/14 , C07D417/14 , A61K31/5377 , A61K31/4545
CPC分类号: A61K31/506 , A61K31/4545 , A61K31/5377 , C07D401/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D491/107
摘要: The invention provides novel imidazole amine compounds according to Formula (I) and Formula (II) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供根据式(I)和式(II)的新型咪唑胺化合物,其用于治疗过度增殖性疾病如癌症的制造和用途。
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公开(公告)号:US09586938B2
公开(公告)日:2017-03-07
申请号:US13810860
申请日:2011-07-28
申请人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
发明人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
IPC分类号: A01N43/54 , C07D239/42 , C07D401/04 , A01N43/42 , A61K31/47 , C07D403/12 , C07D233/90 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/12 , C07D405/14 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D403/14
CPC分类号: C07D403/12 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I),式(II)和式(III)的新型环胺氮杂环甲酰胺,其用于治疗过度增殖性疾病如癌症的制备和用途。
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16.
公开(公告)号:US09321760B2
公开(公告)日:2016-04-26
申请号:US14236405
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Yufang Xiao , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Hui Qiu , Yufang Xiao , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
IPC分类号: A61K31/506 , C07D417/12 , C07D403/12 , C07D401/14 , C07D405/14 , C07D413/14 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D239/48 , C07D413/04 , C07D417/14 , C07D405/12
CPC分类号: A61K31/506 , C07D239/48 , C07D239/49 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I)的新型杂环胺化合物及其制备和用于治疗过度增殖性疾病如癌症的用途。
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公开(公告)号:US20150274750A1
公开(公告)日:2015-10-01
申请号:US14432316
申请日:2013-11-15
申请人: Ruoxi LAN , Bayard R. HUCK , Xiaoling CHEN , Yufang XIAO , MERCK PATENT GMBH
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Yufang Xiao
IPC分类号: C07D498/04 , A61K31/496 , C07D487/04 , A61N5/10 , C07D239/70 , A61K31/517 , A61K31/5383 , A61K45/06 , C07D471/04 , A61K31/519
CPC分类号: C07D498/04 , A61K31/496 , A61K31/517 , A61K31/519 , A61K31/5383 , A61K45/06 , A61N5/10 , A61N2005/1098 , C07D239/70 , C07D471/04 , C07D475/06 , C07D487/04
摘要: The invention provides novel imidazol-piperidinyl derivatives of the formula (I) in which R1, R2, W, X1, X2, X3, X4 and n have the meanings indicated in formula I, and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供式(I)的新型咪唑 - 哌啶基衍生物,其中R1,R2,W,X1,X2,X3,X4和n具有式I所示的含义及其制备和用于治疗过度增殖性疾病 ,如癌症。
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公开(公告)号:US20130217709A1
公开(公告)日:2013-08-22
申请号:US13810860
申请日:2011-07-28
申请人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
发明人: Bayard R. Huck , Xiaoling Chen , Constantin Neagu , Reinaldo Jones , Yufang Xiao , Igor Mochalkin
IPC分类号: C07D403/12 , A61K31/4709 , C07D403/14 , C07D401/12 , C07D401/14 , C07D405/14 , A61K31/517 , A61K45/06
CPC分类号: C07D403/12 , A61K31/4709 , A61K31/517 , A61K45/06 , C07D233/90 , C07D401/04 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/12 , C07D405/14
摘要: The invention provides novel cyclic amine azaheterocyclic carboxamide according to Formula (I), Formula (II) and Formula (III) their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I),式(II)和式(III)的新型环胺氮杂环甲酰胺,其用于治疗过度增殖性疾病如癌症的制备和用途。
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19.
公开(公告)号:US20150126484A1
公开(公告)日:2015-05-07
申请号:US14236405
申请日:2012-09-12
申请人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Yufang Xiao , Hui Qiu , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
发明人: Ruoxi Lan , Bayard R. Huck , Xiaoling Chen , Lizbeth Celeste Deselm , Yufang Xiao , Hui Qiu , Constantin Neagu , Igor Mochalkin , Theresa L. Johnson
IPC分类号: C07D417/12 , A61K31/506 , C07D403/04 , C07D401/04 , C07D401/12 , C07D413/04 , C07D401/14 , C07D413/14 , C07D405/12 , C07D239/48 , C07D403/12
CPC分类号: A61K31/506 , C07D239/48 , C07D239/49 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/06 , C07D413/14 , C07D417/12 , C07D417/14
摘要: The invention provides novel heterocyclic amine compounds according to Formula (I) and their manufacture and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了式(I)的新型杂环胺化合物及其制备和用于治疗过度增殖性疾病如癌症的用途。
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公开(公告)号:US20130252942A1
公开(公告)日:2013-09-26
申请号:US13989199
申请日:2011-11-11
申请人: Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
发明人: Bayard R. Huck , Reinaldo Jones , Yufang Xiao , Constantin Neagu , Donald Bankston , Andreas Goutopoulos
IPC分类号: C07D403/12 , A61K45/06 , A61K31/517
CPC分类号: C07D403/12 , A61K31/517 , A61K45/06
摘要: The invention provides novel quinazoline carboxamide azetidine compounds according to Formula (I) and use for the treatment of hyperproliferative diseases, such as cancer.
摘要翻译: 本发明提供了根据式(I)的新型喹唑啉羧酰胺氮杂环丁烷化合物和用于治疗过度增殖性疾病如癌症的用途。
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