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公开(公告)号：US07571841B2
公开(公告)日：2009-08-11
申请号：US12015227
申请日：2008-01-16
CPC分类号： B25C1/08 , B65D83/207 , B65D83/24 , B65D83/54
摘要： An adapter configured for use in combination with a cap on a fuel cell having a closure formation, the cap having at least one leg portion and a corresponding foot extending from the leg, including a ring portion configured for engagement upon the closure formation of the fuel cell and including a top edge, a bottom edge, and a sidewall therebetween having an inner sidewall and an outer sidewall, a grooved portion defined by the inner sidewall, a convex gripping formation on the outer sidewall complementary to the closure formation, and at least one recessed formation adjacent the grooved portion for receiving the foot.
摘要翻译： 一种被配置为与具有封闭形成的燃料电池上的盖组合使用的适配器，所述盖具有至少一个支脚部分和从所述腿部延伸的对应脚部，所述脚部构造成用于在所述燃料的闭合形成时接合 并且包括顶部边缘，底部边缘和其间具有内侧壁和外侧壁的侧壁，由内侧壁限定的开槽部分，与封闭结构互补的外侧壁上的凸形夹持结构，并且至少 邻近凹槽部分的一个凹陷部分用于接收脚部。
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12.发明授权
公开(公告)号：US5656444A
公开(公告)日：1997-08-12
申请号：US451923
申请日：1995-05-26
IPC分类号： G01N33/574 , A61K38/00 , A61K39/395 , A61P35/00 , C07K1/14 , C07K1/36 , C07K14/82 , C07K16/30 , C07K16/32 , C12N5/10 , C12N15/02 , C12P21/08 , C12R1/91 , C07K16/18 , G01N33/53
CPC分类号： C07K16/30 , C07K14/82 , A61K38/00 , C07K2317/73
摘要： The present invention provides a low cost, less toxic, anti-cancer immunotherapy which enhances the host's immune system ability to destroy or contain cancers, and also provides a diagnostic test for cancer. Specifically, the present invention provides monoclonal antibodies specific for, that is, specifically bind, oncofetal protein (OFP), a cancer cell product. Tumors treated with a single dose of the monoclonal antibodies against OFP are markedly reduced in size, and leukemic populations of cells treated with a single does of monoclonal antibodies against OFP are significantly decreased in number. Since the monoclonal antibodies of the present invention do not bind to tumor cells, the monoclonal antibody treatment overcomes the disadvantages associated with tumor cell targeting. Monoclonal antibodies to OFP offer a simple and inexpensive agent for use as a primary or adjuvant therapy against a wide variety of cancers and tumors in humans and other animals. The monoclonal antibodies against OFP are also employed to detect cancer in animal, including human patients.
摘要翻译： 本发明提供了低成本，毒性较小的抗癌免疫疗法，其增强了宿主的免疫系统破坏或容纳癌症的能力，并且还提供了癌症的诊断试验。 具体地说，本发明提供了特异性，特异性结合成骨蛋白（OFP），癌细胞产物的单克隆抗体。 用单剂量的针对OFP的单克隆抗体治疗的肿瘤的大小显着降低，并且使用单一针对OFP的单克隆抗体处理的细胞的白血病群体的数量显着减少。 由于本发明的单克隆抗体不与肿瘤细胞结合，所以单克隆抗体治疗克服了与肿瘤细胞靶向相关的缺点。 OFP的单克隆抗体提供了一种简单而廉价的药物，可用作针对人类和其他动物中各种癌症和肿瘤的主要或辅助治疗。 针对OFP的单克隆抗体也用于检测动物，包括人类患者中的癌症。
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13.发明授权
公开(公告)号：US4746539A
公开(公告)日：1988-05-24
申请号：US554439
申请日：1983-11-23
CPC分类号： C07K16/30 , Y10S530/828 , Y10S530/83
摘要： It has previously been shown that the serum from patients suffering from a wide range of cancers contains a cancer marker protein having the ability to release RNA from cell nuclei. This cancer marker protein is purified by taking the protein fraction precipitating between 30% and 50% saturated aqueous ammonium sulfate solution, dialyzing a solution of the protein fraction against TMK buffer, chromatographing the dialyzed protein on a molecular sieve and isolating the fraction having a molecular weight of about 60,000; and removing albumin. Injection of the purified protein into rabbits, preparation of serum from blood of the rabbits and absorption of the sera with normal plasma fraction produces at antibody specific to the cancer marker protein and therefore useful in a radioimmunoassay or ELISA test for a wide variety of cancers. Monoclonal antibody preparations to the protein may be prepared by injecting the purified protein into mice, harvesting the spleen and lymph node cells, fusing these cells with mouse myeloma cells and using the resultant hybridoma cells to produce the monoclonal antibody.
摘要翻译： 以前已经显示来自患有广泛癌症的患者的血清含有具有从细胞核释放RNA的能力的癌症标记蛋白。 通过将蛋白质级分沉淀在30％至50％饱和硫酸铵水溶液中，透析蛋白质级分与TMK缓冲液的溶液，色谱分析筛分的蛋白质并分离出分子 重量约6万; 并去除白蛋白。 将纯化的蛋白质注射到兔中，从兔血液制备血清和用正常血浆级分吸收血清，产生对癌症标志物蛋白特异的抗体，因此可用于多种癌症的放射免疫测定或ELISA测试。 可以通过将纯化的蛋白质注射到小鼠中，收获脾脏和淋巴结细胞，将这些细胞与小鼠骨髓瘤细胞融合并使用所得的杂交瘤细胞产生单克隆抗体来制备该蛋白质的单克隆抗体制剂。
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14.发明授权Aluminum-magnesium alloys sheet exhibiting improved properties for forming and method aspects of producing such sheet 失效表现出改善的成型性能的铝 - 镁合金片材和制造这种片材的方法方面
公开(公告)号：US4151013A
公开(公告)日：1979-04-24
申请号：US876577
申请日：1978-02-10
CPC分类号： C22F1/047
摘要： Described is Al-Mg Sheet, in annealed condition, which has good formability and is further characterized structurally by its ability to be formed in the manufacture of sheet-metal products without being marked by Type A Luder lines. Also described are method aspects of producing such sheet, including the steps of selectively annealing and quenching followed by stretching.
摘要翻译： 描述了在退火条件下的Al-Mg片，其具有良好的成形性，并且在结构上通过其在不用A型Luder线标记的钣金制品的制造中形成的能力进一步表征。 还描述了生产这种片材的方法方面，包括选择性退火和淬火，随后拉伸的步骤。
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