-
公开(公告)号:US4210628A
公开(公告)日:1980-07-01
申请号:US1196
申请日:1979-01-05
申请人: Nobutaka Ninomiya , Hiroshi Nishino , Toshio Aibe , Kiyoshi Itoga
发明人: Nobutaka Ninomiya , Hiroshi Nishino , Toshio Aibe , Kiyoshi Itoga
CPC分类号: C01B31/08 , B01D53/8628 , C01B21/02 , C01B31/125
摘要: Nitrogen oxides contained in waste gases can be effectively removed from waste gases by a novel process which comprises contacting the waste gases with activated carbon in the presence of gaseous ammonia at a temperature between about 110.degree. C. and about 350.degree. C. to convert the nitrogen oxides to nitrogen. When waste gases containing sulfur oxides together with nitrogen oxides are subjected to this process, both the nitrogen oxides and the sulfur oxides can be simultaneously removed from the waste gases with a high efficiency. The effects of this process can be enhanced by employing a specific element-supporting activated carbon or an oxidized activated carbon.
摘要翻译: 包含在废气中的氮氧化物可以通过新方法从废气中有效地除去,该方法包括在约110℃至约350℃的温度下,在气态氨存在下使废气与活性炭接触,以将 氮氧化物到氮气。 当含有硫氧化物的废气与氮氧化物一起经受该过程时,可以以高效率同时从废气中除去氮氧化物和硫氧化物。 可以通过使用特定的元素负载活性炭或氧化活性炭来提高该方法的效果。
-
公开(公告)号:US07488498B2
公开(公告)日:2009-02-10
申请号:US11246453
申请日:2005-10-11
申请人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
发明人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
CPC分类号: A61K9/0095 , A61K9/146 , A61K9/1617 , A61K9/1647 , A61K9/1652 , A61K9/2054 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5084 , A61K31/195 , A61K31/198 , A61K45/06 , A61K2300/00
摘要: There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a drug capable of decreasing the post prandial blood glucose level of diabetic patients close to the normal level, or mixing a controlled release drug capable of decreasing the post prandial blood glucose level close to the normal level with an immediate release drug. It is particularly preferable that the drug capable of decreasing the post prandial blood glucose level close to the normal level is nateglinide.
摘要翻译: 提供了一种直接降低餐后血糖水平和接近正常水平的空腹血糖水平的单一制剂,通过释放维持能够降低接近正常的糖尿病患者的餐后血糖水平的药物 或者使用立即释放药物混合能够降低接近正常水平的餐后血糖水平的控释药物。 特别优选能够降低接近正常水平的餐后血糖水平的药物是那格列奈。
-
公开(公告)号:US20060029669A1
公开(公告)日:2006-02-09
申请号:US11246453
申请日:2005-10-11
申请人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
发明人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
IPC分类号: A61K9/22
CPC分类号: A61K9/0095 , A61K9/146 , A61K9/1617 , A61K9/1647 , A61K9/1652 , A61K9/2054 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5084 , A61K31/195 , A61K31/198 , A61K45/06 , A61K2300/00
摘要: There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a drug capable of decreasing the post prandial blood glucose level of diabetic patients close to the normal level, or mixing a controlled release drug capable of decreasing the post prandial blood glucose level close to the normal level with an immediate release drug. It is particularly preferable that the drug capable of decreasing the post prandial blood glucose level close to the normal level is nateglinide.
-
公开(公告)号:US07605180B2
公开(公告)日:2009-10-20
申请号:US10421898
申请日:2003-04-24
申请人: Nobutaka Ninomiya , Chisato Makino , Akira Yabuki
发明人: Nobutaka Ninomiya , Chisato Makino , Akira Yabuki
IPC分类号: A61K31/195 , C07C229/00
CPC分类号: A61K31/192 , A61K31/198
摘要: The present invention discloses, as a immediate-release preparation useful as an antidiabetic, a nateglinide-containing preparation comprising nateglinide as an active ingredient wherein the nateglinide is amorphous.
摘要翻译: 本发明公开了作为抗糖尿病药物的即时释放制剂,其包含那格列奈作为活性成分的那格列奈制剂,其中那格列奈是无定形的。
-
公开(公告)号:US20060127475A1
公开(公告)日:2006-06-15
申请号:US11349225
申请日:2006-02-08
申请人: Chisato Makino , Erika Motomura , Kunikazu Suzuki , Takahiko Andou , Nobutaka Ninomiya , Akira Yabuki
发明人: Chisato Makino , Erika Motomura , Kunikazu Suzuki , Takahiko Andou , Nobutaka Ninomiya , Akira Yabuki
IPC分类号: A61K9/20 , A61K31/195
CPC分类号: A61K31/198 , A61K9/2027 , A61K9/2054
摘要: The present invention provides a small-sized preparation that is easy to take, containing 26% or more of nateglinide and 28% or more of at least one disintegrant selected from the group consisting of carmellose or salts thereof, sodium carboxymethyl starch, croscarmellose sodium, crospovidone, partly pregelatinized starch and low-substituted hydroxypropyl cellulose, based on the total mass of the preparation. The preparation of the present invention has high contents of nateglinide, which can be absorbed immediately to exhibit a hypoglycemic action.
摘要翻译: 本发明提供一种容易服用的小型制剂,其含有所述那格列奈26%或更多,选自羧甲基纤维素或其盐的至少一种崩解剂的28%或更多,羧甲基淀粉钠,交联羧甲基纤维素钠, 交联聚维酮,部分预胶化淀粉和低取代羟丙基纤维素,基于制剂的总质量。 本发明的制剂具有高的那格列奈含量,其可立即被吸收以显示降血糖作用。
-
公开(公告)号:US07022339B2
公开(公告)日:2006-04-04
申请号:US10183322
申请日:2002-06-28
申请人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
发明人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
CPC分类号: A61K9/0095 , A61K9/146 , A61K9/1617 , A61K9/1647 , A61K9/1652 , A61K9/2054 , A61K9/209 , A61K9/2853 , A61K9/2866 , A61K9/5026 , A61K9/5031 , A61K9/5036 , A61K9/5084 , A61K31/195 , A61K31/198 , A61K45/06 , A61K2300/00
摘要: There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a drug capable of decreasing the post prandial blood glucose level of diabetic patients close to the normal level, or mixing a controlled release drug capable of decreasing the post prandial blood glucose level close to the normal level with an immediate release drug. It is particularly preferable that the drug capable of decreasing the post prandial blood glucose level close to the normal level is nateglinide.
-
公开(公告)号:US06830759B2
公开(公告)日:2004-12-14
申请号:US10183405
申请日:2002-06-28
申请人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
发明人: Chisato Makino , Nobutaka Ninomiya , Haruo Orita , Hidetoshi Sakai , Akira Yabuki , Nobuo Kato , Shigeru Shioya
IPC分类号: A61K920
CPC分类号: A61K31/00 , A61K9/2077 , A61K9/2081 , A61K31/195 , A61K45/06
摘要: There is provided a single preparation which directly decreases both of the post prandial blood glucose level and the fasting blood glucose level close to normal levels, by release-sustaining a drug capable of decreasing the post prandial blood glucose level of diabetic patients close to the normal level, or mixing a controlled release drug capable of decreasing the post prandial blood glucose level close to the normal level with an immediate release drug. It is particularly preferable that the drug capable of decreasing the post prandial blood glucose level close to the normal level is nateglinide, repaglinide, or mitiglinide (KAD-1229).
摘要翻译: 提供了一种直接降低餐后血糖水平和接近正常水平的空腹血糖水平的单一制剂,通过释放维持能够降低接近正常的糖尿病患者的餐后血糖水平的药物 或者使用立即释放药物混合能够降低接近正常水平的餐后血糖水平的控释药物。 特别优选能够降低接近正常水平的餐后血糖水平的药物是那格列奈,瑞格列奈或米格列奈(KAD-1229)。
-
公开(公告)号:US6143323A
公开(公告)日:2000-11-07
申请号:US311060
申请日:1999-05-14
申请人: Akira Yabuki , Masato Kaida , Takahiko Ando , Nobutaka Ninomiya , Masanao Ozaki
发明人: Akira Yabuki , Masato Kaida , Takahiko Ando , Nobutaka Ninomiya , Masanao Ozaki
IPC分类号: A61K9/20 , A61K9/28 , A61K9/36 , A61K31/195 , A61K31/198 , A61K47/38 , A61P3/08
CPC分类号: A61K9/2853 , A61K31/195 , A61K31/198 , A61K9/2054 , A61K9/2866 , Y10S514/866
摘要: A tablet composition containing N-(trans-4-isopropylcydohexanecarbonyl)-D-phenylalanine and low substituted hydroxypropylcellulose is disclosed. This tablet composition is rapidly disintegrated in the stomach after the administration and absorbed without being influenced by meals to inhibit the rise of the blood sugar levels of diabetics after meals.
摘要翻译: 公开了含有N-(反式-4-异丙基环己烷羰基)-D-苯丙氨酸和低取代羟丙基纤维素的片剂组合物。 该片剂组合物在施用后在胃中快速崩解,并且不受餐饭的影响而吸收,以抑制餐后糖尿病患者的血糖水平的升高。
-
-
-
-
-
-
-