公开(公告)号：US20070140963A1

公开(公告)日：2007-06-21

申请号：US11553219

申请日：2006-10-26

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048832A1

公开(公告)日：2007-03-01

申请号：US11552647

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dollon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dollon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽组合，编码多肽的多核苷酸以及相关组合物和方法，用于含有Zcytor17的多聚体或异二聚体细胞因子受体，其可用作新的细胞因子拮抗剂，并且用于检测刺激造血细胞增殖和/或发育的配体的方法 ，淋巴和骨髓细胞体外和体内。 本发明还包括用于产生多聚体或异二聚体细胞因子受体的方法，其用途及其抗体。

公开(公告)号：US20070048831A1

公开(公告)日：2007-03-01

申请号：US11552637

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048222A1

公开(公告)日：2007-03-01

申请号：US11553821

申请日：2006-10-27

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  C07K16/28 ,  C07K16/46

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070048834A1

公开(公告)日：2007-03-01

申请号：US11552710

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： C12P21/06 ,  C07H21/04 ,  C07K14/715

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070140964A1

公开(公告)日：2007-06-21

申请号：US11553241

申请日：2006-10-26

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K51/00 ,  A61K39/395 ,  A61K38/17

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070049530A1

公开(公告)日：2007-03-01

申请号：US11552653

申请日：2006-10-25

申请人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

发明人： Cindy Sprecher ,  Zeren Gao ,  Joseph Kuijper ,  Maria Dasovich ,  Francis Grant ,  Scott Presnell ,  Theodore Whitmore ,  Angela Hammond ,  Julia Novak ,  Jane Gross ,  Stacey Dillon

IPC分类号： A61K38/17 ,  C07K14/705 ,  C07H21/04 ,  C12P21/06

CPC分类号： C07K16/2866 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/52 ,  C07K14/715 ,  C07K2317/24 ,  C07K2317/76

摘要： Novel polypeptide combinations, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor17-containing multimeric or heterodimer cytokine receptors that may be used as novel cytokine antagonists, and within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. The present invention also includes methods for producing the multimeric or heterodimeric cytokine receptor, uses therefor and antibodies thereto.

公开(公告)号：US20070249533A1

公开(公告)日：2007-10-25

申请号：US11691000

申请日：2007-03-26

申请人： Steven Levin ,  Mark Rixon ,  Zeren Gao ,  Katherine Lewis ,  Janine Bilsborough ,  David Taft

发明人： Steven Levin ,  Mark Rixon ,  Zeren Gao ,  Katherine Lewis ,  Janine Bilsborough ,  David Taft

IPC分类号： A61K38/00 ,  A61P17/00 ,  C07H21/02 ,  C07K14/00 ,  C07K16/00 ,  C12N15/00 ,  C12N5/06 ,  C12P21/06

CPC分类号： C07K14/54 ,  A61K38/00 ,  A61K2039/505 ,  C07K16/2866 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2319/00 ,  C07K2319/30 ,  C12P21/02 ,  Y02A50/401

摘要： The present invention relates antagonists of IL-17A and IL-17F. The antagonists of the invention are based on IL-17RC alone or on both IL-17RC and IL-17RA (“IL-17RC/IL-17RA”). Such antagonists serve to block, inhibit, reduce, antagonize or neutralize the activity of IL-17F, IL-17A, or both IL-17A and IL-17F. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. IL-17RA is a receptor for IL-17A and IL-17RC is a common receptor for both IL-17A and IL-17F. The present invention includes soluble IL-17A and IL-17F anatagonists, as well as methods for using the same.

摘要翻译： 本发明涉及IL-17A和IL-17F的拮抗剂。 本发明的拮抗剂基于单独的IL-17RC或IL-17RC和IL-17RA（“IL-17RC / IL-17RA”）两者。 这种拮抗剂用于阻断，抑制，降低，拮抗或中和IL-17F，IL-17A或IL-17A和IL-17F两者的活性。 IL-17A和IL-17F是参与炎症过程和人类疾病的细胞因子。 IL-17RA是IL-17A的受体，IL-17RC是IL-17A和IL-17F的常见受体。 本发明包括可溶性IL-17A和IL-17F拮抗剂，以及使用它们的方法。

公开(公告)号：US20060142192A1

公开(公告)日：2006-06-29

申请号：US11253200

申请日：2005-10-18

申请人： Zeren Gao ,  Rolf Kuestner ,  Mark Appleby ,  Katherine Lewis ,  Patricia McKernan ,  Shannon Okada ,  David Taft ,  Joseph Kuijper ,  Stephen Jaspers ,  Steven Levin

发明人： Zeren Gao ,  Rolf Kuestner ,  Mark Appleby ,  Katherine Lewis ,  Patricia McKernan ,  Shannon Okada ,  David Taft ,  Joseph Kuijper ,  Stephen Jaspers ,  Steven Levin

IPC分类号： A61K38/17 ,  C07K14/715

CPC分类号： C07K14/7155 ,  A61K38/00 ,  A61K39/395 ,  A61K47/50 ,  A61K47/60 ,  C07K14/54 ,  C07K16/00

摘要： The present invention relates ZcytoR21 antagonists, such as soluble receptors and anti-ZcytoR21 antibodies, that are useful in blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17C. IL-17C is a cytokine that is involved in inflammatory processes and human disease. ZcytoR21 is a receptor for IL-17C. The present invention includes soluble ZcytoR21, anti-ZcytoR21 antibodies and binding partners, as well as methods for antagonizing IL-17C using such soluble receptors, antibodies and binding partners.

摘要翻译： 本发明涉及可用于阻断，抑制，降低，拮抗或中和IL-17C活性的ZcytoR21拮抗剂，例如可溶性受体和抗ZcytoR21抗体。 IL-17C是涉及炎症过程和人类疾病的细胞因子。 ZcytoR21是IL-17C的受体。 本发明包括可溶性ZcytoR21，抗ZcytoR21抗体和结合配偶体，以及使用这种可溶性受体，抗体和结合配偶体拮抗IL-17C的方法。

公开(公告)号：US20070197441A1

公开(公告)日：2007-08-23

申请号：US11673914

申请日：2007-02-12

申请人： Mark Rixon ,  Zeren Gao ,  Steven Levin ,  Brenda Stevens

发明人： Mark Rixon ,  Zeren Gao ,  Steven Levin ,  Brenda Stevens

IPC分类号： A61K38/17 ,  C07K14/715

CPC分类号： C07K14/7155 ,  A61K38/00 ,  C07K2319/30

摘要： The present invention relates to blocking, inhibiting, reducing, antagonizing or neutralizing the activity of IL-17A alone, or both IL-17A and IL-17F polypeptide molecules. IL-17A and IL-17F are cytokines that are involved in inflammatory processes and human disease. IL-17RA is a receptor for IL-17A and does also bind IL-17F. The present invention includes a truncated soluble IL-17RA, as well as methods for antagonizing IL-17A or both IL-17A and IL-17F using such a truncated soluble receptor.

摘要翻译： 本发明涉及阻断，抑制，降低，拮抗或中和IL-17A单独或IL-17A和IL-17F多肽分子的活性。 IL-17A和IL-17F是参与炎症过程和人类疾病的细胞因子。 IL-17RA是IL-17A的受体，并且还结合IL-17F。 本发明包括截短的可溶性IL-17RA，以及使用这种截短的可溶性受体拮抗IL-17A或IL-17A和IL-17F两者的方法。