公开(公告)号：US06709676B2

公开(公告)日：2004-03-23

申请号：US10175480

申请日：2002-06-19

申请人： Wing-Kee Philip Cho

发明人： Wing-Kee Philip Cho

IPC分类号： A61K924

CPC分类号： A61K31/4545 ,  A61K9/2009 ,  A61K9/2013 ,  A61K9/209 ,  A61K31/137 ,  A61K31/445 ,  A61K31/473 ,  A61K47/02 ,  A61K47/12 ,  A61K47/183 ,  A61K31/135 ,  A61K2300/00

摘要： A bilayer solid composition comprising (a) an immediate release first layer comprising an anti-allergic effective amount of desloratadine and at least one pharmaceutically acceptable excipient and (b) a sustained release second layer comprising an effective amount of a nasal decongestant, e.g. pseudoephedrine sulfate and a pharmaceutically acceptable sustained release agent wherein the composition contains less than about 2% of desloratadine decomposition products is disclosed. A solid composition comprising an anti-allergic effective amount of desloratadine and at least one, and preferably two pharmaceutically acceptable antioxidants is also disclosed.

公开(公告)号：US07612058B2

公开(公告)日：2009-11-03

申请号：US10998400

申请日：2004-11-29

申请人： Wing-Kee Philip Cho

发明人： Wing-Kee Philip Cho

IPC分类号： A61K31/00

CPC分类号： A61K45/06 ,  A61K31/216 ,  A61K31/397 ,  A61K2300/00

摘要： The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols.

摘要翻译： 本发明提供组合物，治疗组合和方法，包括：（a）至少一种过氧化物酶体增殖物激活受体激活剂; 和（b）至少一种取代的氮杂环丁酮或取代的β-内酰胺甾醇吸收抑制剂，其可用于治疗血管疾病，糖尿病，肥胖症和降低甾醇的血浆水平。

公开(公告)号：US07030106B2

公开(公告)日：2006-04-18

申请号：US10136968

申请日：2002-05-01

申请人： Wing-Kee Philip Cho

发明人： Wing-Kee Philip Cho

IPC分类号： A61K31/397 ,  A61K9/20 ,  A61K6/00 ,  A61K7/00

CPC分类号： A61K45/06 ,  A61K31/216 ,  A61K31/397 ,  A61K2300/00

摘要： The present invention provides compositions, therapeutic combinations and methods including: (a) at least one peroxisome proliferator-activated receptor activator; and (b) at least one substituted azetidinone or substituted β-lactam sterol absorption inhibitor which can be useful for treating vascular conditions, diabetes, obesity and lowering plasma levels of sterols.

公开(公告)号：US07718643B2

公开(公告)日：2010-05-18

申请号：US12472021

申请日：2009-05-26

申请人： Wing-Kee Philip Cho

发明人： Wing-Kee Philip Cho

IPC分类号： A61K31/397 ,  A61K31/35 ,  A61K31/34

CPC分类号： A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/22 ,  A61K31/35 ,  A61K31/365 ,  A61K31/397 ,  A61K31/40 ,  A61K45/06 ,  A61K2300/00

摘要： The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.

摘要翻译： 本发明提供由胆固醇吸收抑制剂和HMG-CoA还原酶抑制剂，一种或多种抗氧化剂，微晶纤维素，羟丙基甲基纤维素，硬脂酸镁和乳糖组成的药物组合物。 组合物不需要含有抗坏血酸以获得所需的稳定性。

公开(公告)号：US20090253675A1

公开(公告)日：2009-10-08

申请号：US12472021

申请日：2009-05-26

申请人： Wing-Kee Philip Cho

发明人： Wing-Kee Philip Cho

IPC分类号： A61K31/397 ,  A61K47/34 ,  A61K31/351 ,  A61K31/40 ,  A61P9/10

CPC分类号： A61K9/2013 ,  A61K9/2018 ,  A61K9/2054 ,  A61K31/22 ,  A61K31/35 ,  A61K31/365 ,  A61K31/397 ,  A61K31/40 ,  A61K45/06 ,  A61K2300/00

摘要： The instant invention provides a pharmaceutical composition comprised of a cholesterol absorption inhibitor and an HMG-CoA reductase inhibitor, one or more anti-oxidants, microcrystalline cellulose, hydroxypropyl methylcellulose, magnesium stearate and lactose. The composition need not contain ascorbic acid in order to obtain desirable stability.

摘要翻译： 本发明提供由胆固醇吸收抑制剂和HMG-CoA还原酶抑制剂，一种或多种抗氧化剂，微晶纤维素，羟丙基甲基纤维素，硬脂酸镁和乳糖组成的药物组合物。 组合物不需要含有抗坏血酸以获得所需的稳定性。