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    Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors
    12.
    发明授权
    Substituted 5-(pyrazin-2-yl)-1H-pyrazolo [3, 4-B] pyridine and pyrazolo [3, 4-B] pyridine derivatives as protein kinase inhibitors 有权
    取代的5-（吡嗪-2-基）-1H-吡唑并[3,4-B]吡啶和吡唑并[3,4-B]吡啶衍生物作为蛋白激酶抑制剂

    公开(公告)号：US08791112B2

    公开(公告)日：2014-07-29

    申请号：US13435327

    申请日：2012-03-30

    申请人： Hariprasad Vankayalapati ,  Rajendra P Appalaneni ,  Y. Vekata Krishna Reddy

    发明人： Hariprasad Vankayalapati ,  Rajendra P Appalaneni ,  Y. Vekata Krishna Reddy

    IPC分类号： A61K31/535 ,  A61K31/497 ,  C07D401/04 ,  C07D471/04

    CPC分类号： A61K31/497 ,  A61K31/5377 ,  C07C249/00 ,  C07D471/04

    摘要： Substituted 5-(pyrazin-2-yl)-1H-pyrazolo[3,4-b]pyridine, 5-(pyrazin-2-yl)-1H-pyrrolo[2,3-b]pyridine and pyrazolo[3,4-b]pyridine derivatives according to formula I, II and VII, and methods for making same, which are inhibitors of constitutively activated Tyrosine Kinase-Like (TKL), CMGC protein kinases family members and can be useful in the treatment of Parkinson's disease, Alzheimer's disease, Down's Syndrome, Huntington's disease, other neurodegenerative and central nervous system disorders, cancer, metabolic disorders and inflammatory diseases. Also disclosed are pharmaceutical compositions including the compounds and methods of inhibiting wild type and/or mutated protein kinase activities of these families and the treatment of disorders associated therewith using compounds and pharmaceutical compositions including the compounds.

    摘要翻译： 取代5-（吡嗪-2-基）-1H-吡唑并[3,4-b]吡啶，5-（吡嗪-2-基）-1H-吡咯并[2,3-b]吡啶和吡唑并[3,4 -b]吡啶衍生物及其制备方法，其为组成型激活酪氨酸激酶（TKL），CMGC蛋白激酶家族成员的抑制剂，可用于治疗帕金森病， 阿尔茨海默病，唐氏综合症，亨廷顿病，其他神经变性和中枢神经系统疾病，癌症，代谢紊乱和炎性疾病。 还公开了包括这些化合物的化合物和抑制这些家族的野生型和/或突变的蛋白激酶活性的方法的药物组合物，以及使用包括该化合物的化合物和药物组合物治疗与其相关的病症。