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公开(公告)号：US10040811B2
公开(公告)日：2018-08-07
申请号：US14387520
申请日：2013-03-15
申请人： Merck Patent GmbH
摘要： Organic compounds which contain nitrogen, fluorine, and phosphorus atoms together with carbon atoms and hydrogen atoms and which can be used as a multi-element standard for 1H—, 13C—, 15N—, 19F—, and 31P nuclear magnetic resonance spectroscopy. Also, a nuclear magnetic resonance spectroscopy method, preferably a quantitative nuclear magnetic resonance spectroscopy method, using said compounds and a method for qualitatively and/or quantitatively determining an analyte using such a nuclear magnetic resonance spectroscopy method.
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22.发明授权公开(公告)号：US10039838B2
公开(公告)日：2018-08-07
申请号：US14936969
申请日：2015-11-10
发明人： Masanobu Komatsu , David Mann , Erkki Ruoslahti
IPC分类号： C07K7/06 , A61K38/08 , A61K47/48 , A61K45/06 , A61K31/506 , A61K31/551 , C12Q1/6883 , A61K47/64 , A61K38/00
摘要： Disclosed are compositions and methods useful for delivering targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to effect a beneficial therapeutic result. The disclosed targeting is useful for delivering therapeutic and detectable agents to diseased tissue in an animal.
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23.发明授权公开(公告)号：US09982011B2
公开(公告)日：2018-05-29
申请号：US14655869
申请日：2013-12-23
IPC分类号： C07K1/107 , C07K5/103 , C07K19/00 , C07H15/26 , C07H15/252 , A61K31/704 , A61K47/65 , A61K47/54
CPC分类号： C07K1/1077 , A61K31/704 , A61K47/542 , A61K47/545 , A61K47/65 , C07H15/252 , C07H15/26 , C07K5/1008 , C07K5/101
摘要： The present invention discloses doxorubicin derivatives for targeted activation by Legumain, its preparation method and use. The doxorubicin derivatives are obtained by condensation between the amino group of compound A and the carboxyl group of compound B and have the following structure: compounds A and B have the following structures, respectively: wherein R3 in compound B is Len or absent; R4 is any one amino acid selected from the group consisting of Ala and Thr; R5 is any one amino acid selected from the group consisting of Ala, Thr and Asn; R6 is wherein n=1-20; or wherein R7 is substituted or unsubstituted, linear or branched, saturated or unsaturated C1-C20 fatty hydrocarbon, or substituted or unsubstituted C6-C20 aromatic hydrocarbon. The doxorubicin derivatives of the present invention are specifically tumor-targeted and have a long in vivo metabolic half-life, as compared with doxorubicin. They exhibit an efficient and safe anti-tumor effect and could be used to prepare an anti-tumor drug.
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公开(公告)号：US09890031B2
公开(公告)日：2018-02-13
申请号：US15266395
申请日：2016-09-15
申请人： LJ Crafted Wines
发明人： Lowell Jooste
CPC分类号： B67D3/04 , B67D1/0412 , B67D1/0829 , B67D3/0048 , B67D3/0064 , B67D3/0093
摘要： An apparatus for dispensing an alcoholic beverage from a barrel without the risk of spoilage from oxidation and a method for installing the apparatus in a barrel.
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公开(公告)号：US09834427B2
公开(公告)日：2017-12-05
申请号：US14903003
申请日：2014-07-07
申请人： Scott Williams
发明人： Scott Williams
CPC分类号： B67D1/0841 , B67D1/0081 , B67D1/0831
摘要： A keg adapter to alleviate keg valve coupler system incompatibility. The keg adapter has a first end and a second end, the first end being compatible with at least one tap head coupler and having a diameter greater than the second end and the second and being compatible with at least one keg valve system. The keg adapter may be compatible with any combination of tap head coupler and keg valve system. A method of installing the keg adapter onto a keg for dispensing beer is disclosed. Also a method of using a keg adapter to dispense beer from a keg.
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公开(公告)号：US09766439B2
公开(公告)日：2017-09-19
申请号：US14874374
申请日：2015-10-02
申请人： Solenica
发明人： Diva Tommei , Daniele Tommei
CPC分类号： G02B19/0042 , F21S11/005 , F24S23/77 , F24S30/45 , F24S50/20 , F24S80/50 , F24S2080/503 , G01S3/7861 , G02B7/1827 , G02B19/0019
摘要： A heliostat contained within a mechanical enclosure is described that optimizes the heliostat for domestic applications by emphasizing features of durability, protection from outside weather, low cost of manufacture, self-powering, light-weight, and aesthetics.
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公开(公告)号：USD795365S1
公开(公告)日：2017-08-22
申请号：US29531761
申请日：2015-06-29
申请人： Hat Fitness, LLC
设计人： Robert Peritz , Yuval Shenkal , John Grimm
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公开(公告)号：US09736566B2
公开(公告)日：2017-08-15
申请号：US14425306
申请日：2014-11-21
申请人： 1MORE INC.
发明人： Kuanhong Hsieh , Boqing Lin , Xiaohong Sun
IPC分类号： H04R1/10 , H04R3/04 , H04R5/04 , H04R3/00 , G06F1/32 , H03G3/00 , G06F1/30 , H04M1/72 , H04M1/725 , H04M1/60
CPC分类号： H04R1/1041 , G06F1/305 , G06F1/3203 , H03G3/002 , H03G3/007 , H04M1/60 , H04M1/72 , H04M1/725 , H04R1/10 , H04R1/1033 , H04R3/00 , H04R3/04 , H04R5/04 , H04R2420/07
摘要： An earphone line control device includes a power supply management unit, a filter unit, a switching circuit and a control unit. The switching circuit includes a switch in series with a resistance, a first end of the power supply management unit and an end of the filter unit are both connected to a power supply, a second end of the power supply management unit is connected to a first end of the control unit, the other end of the filter unit is connected to a second end of the control unit, a third end of the power supply management unit is connected to ground, a third end of the control unit is connected to ground, an end of the resistance is connected to the power supply, the other end of the resistance is in series with an end of the switch and connected to a fifth end of the control unit, and the other end of the switch is connected to a forth end of the control unit. When the switch is turned off, the control unit outputs a preset coded pulse signal.
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公开(公告)号：US09655973B2
公开(公告)日：2017-05-23
申请号：US14383818
申请日：2013-03-11
申请人： Vascular Biosciences
发明人： David M. Mann
IPC分类号： A61K38/08 , A61K47/42 , A61K45/06 , C07K7/06 , A61K47/48 , A61K9/00 , A61K31/506 , A61K31/519 , A61K38/00
CPC分类号： A61K47/42 , A61K9/0053 , A61K31/506 , A61K31/519 , A61K38/00 , A61K45/06 , A61K47/62 , C07K7/06
摘要： Disclosed are compositions and methods useful for oral delivery of targeted therapies for pulmonary diseases, fibrotic disorders and cancer. The compositions and methods are based on peptide sequences that selectively bind to and home to diseased tissue and enable targeted therapies to affect a beneficial therapeutic result. The disclosed targeting is useful for oral delivery of therapeutic and detectable agents to diseased tissue in an animal.
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公开(公告)号：US09603890B2
公开(公告)日：2017-03-28
申请号：US14649455
申请日：2013-12-03
申请人： Vascular Biosciences
发明人： David Mann
CPC分类号： A61K38/08 , A61K45/06 , C12Q1/34 , G01N33/6893 , G01N2333/926 , G01N2800/12 , G01N2800/321
摘要： Disclosed are compositions and methods for triggering disease selective macropinocytosis. The compositions can serve as a marker of disease activity and as a trigger of enhanced macropinocytosis in tissues undergoing disease remodeling such as wound healing, cancer, PAH, inflammation, diabetes, Crohn's disease, ulcerative colitis, ankylosing spondylitis, diseases of the endometrium, psoriasis, irritable bowel syndrome, arthritis, fibrotic disorders, interstitial cystitis, autoimmune diseases, asthma, acute lung injury, and adult respiratory distress syndrome. The compositions can also serve as a receptor for disease selective cell penetrating peptides in the cells and extracellular matrix of diseased tissues.
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