公开(公告)号：US20240192197A1

公开(公告)日：2024-06-13

申请号：US18554490

申请日：2022-04-07

Applicant: CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

Inventor： Hai JIANG ,  Shishuang CHEN ,  Yankai CHU

IPC: G01N33/50 ,  C07K14/47

CPC classification number: G01N33/5023 ,  C07K14/4747 ,  C07K2319/70 ,  G01N2333/46 ,  G01N2500/10

Abstract: Provided is a novel screening system for a drug target antagonist based on cell life/death phenotype. Specifically, on the basis of a target protein and a conditional suicide protein FKBP 12 (F36V)-Caspase9, a screening system is designed for screening a target protein inhibitor or a degradation agent. The screening system is stable and efficient, the phenotype is obviously easy to observe, and the screening system can be used for high-throughput screening.

公开(公告)号：US20230305187A1

公开(公告)日：2023-09-28

申请号：US18041497

申请日：2021-07-13

Applicant: Pei Chen ,  Rui Liu ,  Center for Excellence in Molecular Cell Science, Chinese Academy of Sciences

Inventor： Luonan Chen ,  Pei Chen ,  Rui Liu

IPC: G01W1/02

CPC classification number: G01W1/02

Abstract: The invention discloses a multi-step prediction method and system of future wind speed based on automatic reservoir neural network, realizes accurate and fast multi-step prediction of future information, maintains high robustness to noise and system time-varying, and avoids over-fitting problems. The technical scheme is: for short-term high-dimensional wind speed data, based on the delay embedding theory, the observed high-dimensional dynamics is used as the reservoir by using space-time information transformation, and the high-dimensional wind speed data is mapped to the future information of the target variable. The automatic reservoir neural network realizes the multi-step prediction of the target variable by solving a pair of conjugate space-time information interaction equations.

公开(公告)号：US20220243270A1

公开(公告)日：2022-08-04

申请号：US17433568

申请日：2019-12-10

Applicant: CENTER FOR EXCELLENCE IN MOLECULAR CELL SCIENCE, CHINESE ACADEMY OF SCIENCES

Inventor： Lingling CHEN ,  Li YANG ,  Chuxiao LIU ,  Xiang LI ,  Fang NAN

IPC: C12Q1/6883 ,  A61K45/06 ,  A61K31/713 ,  A61P37/02

Abstract: The present invention provides use of a circular RNA with an incomplete double-stranded structure of 16 bp-33 bp in length and/or a promoting agent of the circular RNA with an incomplete double-stranded structure of 16 bp-33 bp in length in preparation of a medicament for treating systemic lupus erythematosus.