公开(公告)号：US20060052591A1

公开(公告)日：2006-03-09

申请号：US10311822

申请日：2001-01-25

申请人： Bryan Boyle ,  Chiaoyun Kuo ,  Matthew Arterburn ,  Y Tang ,  Chenghua Liu ,  Radoje Drmanac

发明人： Bryan Boyle ,  Chiaoyun Kuo ,  Matthew Arterburn ,  Y Tang ,  Chenghua Liu ,  Radoje Drmanac

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C07K14/705

CPC分类号： C12N9/6432 ,  C07K14/70503 ,  C12Y304/21006

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleoddes and mutants or variants thereof that correspond to a novel human secreted CEA-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from rectum (Hyseq clone identification numbers 15456780 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted CEA-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，以及与新型人分泌的CEA样多肽相对应的突变体或其变体。 这些多核苷酸包含从直肠cDNA文库（Hyseq克隆鉴定号15456780（SEQ ID NO：1））分离的核酸序列。 本发明的其它方面包括含有用于产生新的人分泌的CEA样多肽的方法的载体和对这些多肽具有特异性的抗体。

公开(公告)号：US20060051759A1

公开(公告)日：2006-03-09

申请号：US10517696

申请日：2003-06-16

申请人： Susana Salceda ,  Roberto Macina ,  Leah Turner ,  Yongming Sun ,  Chenghua Liu

发明人： Susana Salceda ,  Roberto Macina ,  Leah Turner ,  Yongming Sun ,  Chenghua Liu

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6886 ,  A61K38/00 ,  A61K39/00 ,  C07K14/4748 ,  C12Q2600/112

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性乳腺细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定诊断，监测，分期，成像和治疗乳腺癌和非癌性疾病状态，识别乳腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程乳腺组织的生产。

公开(公告)号：US20050208488A1

公开(公告)日：2005-09-22

申请号：US10311826

申请日：2000-12-22

申请人： Bryan Boyle ,  Nancy Mize ,  Matthew Arterburn ,  Y. Tang ,  Chenghua Liu ,  Radoje Drmanac

发明人： Bryan Boyle ,  Nancy Mize ,  Matthew Arterburn ,  Y. Tang ,  Chenghua Liu ,  Radoje Drmanac

IPC分类号： A61K38/00 ,  C07K14/47 ,  C07K14/475 ,  C12Q1/68 ,  C07H21/04 ,  C07K14/755 ,  C12N15/09 ,  C12P21/04 ,  G01N33/53

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/475

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human von Willebrand/Thrombospondin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human fetal brain (Hyseq clone identification number 15258924). Other aspects of the invention include vectors containing processes for producing novel human von Willebrand/Thrombospondin-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人血管性血友病素/血小板反应蛋白样多肽的突变体或其变体相对应。 这些多核苷酸包含从人胎脑的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号15258924）。 本发明的其它方面包括含有生产新的人血管性血友病/血小板凝集素样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US20050123551A1

公开(公告)日：2005-06-09

申请号：US10499353

申请日：2002-12-20

申请人： Yongming Sun ,  Chenghua Liu

发明人： Yongming Sun ,  Chenghua Liu

IPC分类号： G01N33/53 ,  A61K31/7088 ,  A61K38/00 ,  A61K39/00 ,  A61K39/395 ,  A61K45/00 ,  A61K48/00 ,  A61P15/00 ,  A61P35/00 ,  C07H21/04 ,  C07K14/47 ,  C07K14/82 ,  C07K16/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/00 ,  C12Q1/68 ,  G01N33/566 ,  G01N33/574

CPC分类号： C07K14/47 ,  C12Q1/6886 ,  C12Q2600/156 ,  C12Q2600/158

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic endometrial cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating endometrial cancer and non-cancerous disease states in endometrial, identifying endometrial tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered endometrial tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性子宫内膜细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括识别，诊断，监测，分期，成像和治疗子宫内膜中的子宫内膜癌和非癌性疾病状态，鉴定子宫内膜组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的产生，以及用于治疗和研究的工程子宫内膜组织的产生。

公开(公告)号：US20050084899A1

公开(公告)日：2005-04-21

申请号：US11005609

申请日：2004-12-06

申请人： Susana Salceda ,  Roberto Macina ,  Herve Recipon ,  Robert Cafferkey ,  Yongming Sun ,  Chenghua Liu ,  Leah Turner

发明人： Susana Salceda ,  Roberto Macina ,  Herve Recipon ,  Robert Cafferkey ,  Yongming Sun ,  Chenghua Liu ,  Leah Turner

IPC分类号： C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C12Q1/68 ,  C12Q1/6886 ,  G01N33/574 ,  C07H21/04 ,  C07K14/72

CPC分类号： G01N33/57415 ,  A61K2039/505 ,  C07K14/47 ,  C12Q1/6886 ,  C12Q2600/158

摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic breast cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast cancer and non-cancerous disease states in breast tissue, identifying breast tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast tissue for treatment and research.

公开(公告)号：US06635742B1

公开(公告)日：2003-10-21

申请号：US09653274

申请日：2000-08-31

申请人： Bryan J. Boyle ,  George Yeung ,  Matthew C. Arterburn ,  Nancy K. Mize ,  Y. Tom Tang ,  Chenghua Liu ,  Radoje T. Drmanac

发明人： Bryan J. Boyle ,  George Yeung ,  Matthew C. Arterburn ,  Nancy K. Mize ,  Y. Tom Tang ,  Chenghua Liu ,  Radoje T. Drmanac

IPC分类号： C07K1600

CPC分类号： C12N9/6432 ,  A61K38/00 ,  C07K14/4703 ,  C07K14/70503 ,  C07K14/715 ,  C07K16/00 ,  C12N9/16 ,  C12Y304/21006

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human secreted semaphorin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from fetal liver-spleen (Hyseq clone identification numbers 5688868 (SEQ ID NO: 1)). Other aspects of the invention include vectors containing processes for producing novel human secreted semaphorin-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人分泌的信号素样多肽的突变体或其变体。 这些多核苷酸包含从胎儿肝脾cDNA文库分离的核酸序列（Hyseq克隆鉴定号5688868（SEQ ID NO：1））。 本发明的其它方面包括含有用于产生新的人分泌的信号素样多肽的方法的载体和对这些多肽具有特异性的抗体。

公开(公告)号：US06465620B1

公开(公告)日：2002-10-15

申请号：US09602543

申请日：2000-06-21

申请人： Bryan J. Boyle ,  Nancy K. Mize ,  Matthew C. Arterburn ,  Y. Tom Tang ,  John S. Tillinghast ,  Ankura Sinku ,  Chenghua Liu ,  Radoje T. Drmanac

发明人： Bryan J. Boyle ,  Nancy K. Mize ,  Matthew C. Arterburn ,  Y. Tom Tang ,  John S. Tillinghast ,  Ankura Sinku ,  Chenghua Liu ,  Radoje T. Drmanac

IPC分类号： C07K100

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  C07K14/78

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to a novel human von Willebrand/Thrombospondin-like polypeptide. These polynucleotides comprise nucleic acid sequences isolated from cDNA library from human fetal brain (Hyseq clone identification number 15258924). Other aspects of the invention include vectors containing processes for producing novel human von Willebrand/Thrombospondin-like polypeptides, and antibodies specific for such polypeptides.

摘要翻译： 本发明提供了由这样的多核苷酸编码的新型多核苷酸和多肽，其与对应于新型人血管性血友病素/血小板反应蛋白样多肽的突变体或其变体相对应。 这些多核苷酸包含从人胎脑的cDNA文库中分离的核酸序列（Hyseq克隆鉴定号15258924）。 本发明的其它方面包括含有生产新的人血管性血友病/血小板凝集素样多肽的方法的载体和对这些多肽特异的抗体。

公开(公告)号：US07678889B2

公开(公告)日：2010-03-16

申请号：US10523834

申请日：2003-08-06

申请人： Roberto A. Macina ,  Susana Salceda ,  Chenghua Liu ,  Yongming Sun ,  Leah R. Turner

发明人： Roberto A. Macina ,  Susana Salceda ,  Chenghua Liu ,  Yongming Sun ,  Leah R. Turner

IPC分类号： C07K16/00

CPC分类号： C07K14/82 ,  A61K38/00 ,  A61K39/00 ,  C07K14/47

摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and noncancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括在卵巢中识别，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，鉴定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

公开(公告)号：US07361475B2

公开(公告)日：2008-04-22

申请号：US11042241

申请日：2005-01-25

申请人： Yongming Sun ,  Herve E. Recipon ,  Malavika G. Ghosh ,  Chenghua Liu

发明人： Yongming Sun ,  Herve E. Recipon ,  Malavika G. Ghosh ,  Chenghua Liu

IPC分类号： G01N33/53 ,  C07K16/00 ,  A61K39/395

CPC分类号： C07K14/47 ,  A61K38/00 ,  A61K2039/505 ,  A61K2039/53

摘要： The present invention relates to newly identified nucleic acids and polypeptides present in normal and neoplastic colon cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions comprising the nucleic acids, polypeptides, antibodies, variants, derivatives, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating colon cancer and non-cancerous disease states in colon tissue, identifying colon tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered colon tissue for treatment and research.

摘要翻译： 本发明涉及存在于正常和肿瘤性结肠细胞中的新鉴定的核酸和多肽，包括核酸和多肽的片段，变体和衍生物。 本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。 本发明还涉及包含本发明的核酸，多肽，抗体，变体，衍生物，激动剂和拮抗剂以及使用这些组合物的方法的组合物。 这些用途包括鉴定，诊断，监测，分期，成像和治疗结肠组织中的结肠癌和非癌性疾病状态，鉴定结肠组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。 用途还包括基因治疗，转基因动物和细胞的生产以及用于治疗和研究的工程结肠组织的生产。

公开(公告)号：US07109030B2

公开(公告)日：2006-09-19

申请号：US10218325

申请日：2002-08-12

申请人： Douglas A. Dedera ,  Victoria Yamazaki ,  Vinod Asundi ,  Chenghua Liu ,  Y. Tom Tang ,  Radoje T. Drmanac

发明人： Douglas A. Dedera ,  Victoria Yamazaki ,  Vinod Asundi ,  Chenghua Liu ,  Y. Tom Tang ,  Radoje T. Drmanac

IPC分类号： C12N15/00 ,  G01N33/53 ,  A61K38/00 ,  C07K14/435

CPC分类号： G01N33/57488 ,  A61K38/00 ,  C07K14/71 ,  G01N2333/65

摘要： The invention provides novel polynucleotides and polypeptides encoded by such polynucleotides and mutants or variants thereof that correspond to novel human secreted IGFBP-like polypeptides. Other aspects of the invention include vectors containing processes for producing novel human secreted IGFBP-like polypeptides, compositions, and methods of use for such polypeptides including in cancer.

摘要翻译： 本发明提供由这样的多核苷酸编码的新型多核苷酸和多肽，其对应于新型人分泌的IGFBP样多肽的突变体或其变体。 本发明的其它方面包括含有生产新型人分泌IGFBP样多肽的方法的载体，组合物，以及包括癌症在内的多肽的使用方法。