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公开(公告)号:US20130296333A1
公开(公告)日:2013-11-07
申请号:US13937477
申请日:2013-07-09
申请人: Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
发明人: Dai Cheng , Dong Han , Guobao Zhang , Yongqin Wan , Yun Feng Xie , Jiqing Jiang , Wenqi Gao , Shifeng Pan
IPC分类号: C07D401/12 , C07D473/00 , C07D401/14 , C07D405/14 , C07D409/14 , C07D471/04
CPC分类号: C07D401/12 , A61K31/47 , C07D217/04 , C07D217/08 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D409/14 , C07D417/12 , C07D471/04 , C07D473/00 , C07D487/04 , C07D513/04
摘要: The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
摘要翻译: 本发明提供了调节刺猬蛋白信号通路活性的方法,化合物和组合物。 特别地,本发明提供了一种抑制由诸如Ptc功能丧失,hedgehog功能增益,平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法,包括使细胞接触 与足量的式(I)化合物反应。
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公开(公告)号:US08178563B2
公开(公告)日:2012-05-15
申请号:US12299290
申请日:2007-05-04
申请人: Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
发明人: Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
IPC分类号: A61K31/44 , C07D213/72
CPC分类号: C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译: 本发明提供了一种调节刺猬蛋白信号通路活性的方法。 特别地,本发明提供了一种抑制由诸如Ptc功能丧失,hedgehog功能增益,平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法,包括使细胞接触 与足量的式I化合物反应。
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公开(公告)号:US08178526B2
公开(公告)日:2012-05-15
申请号:US12664651
申请日:2008-06-12
申请人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
发明人: Badry Bursulaya , Dai Cheng , Jiqing Jiang , Donald S. Karanewsky , Yi Liu , Shifeng Pan , Yongqin Wan , Xia Wang , Yun Feng Xie , Yang Yang
IPC分类号: C07D413/02 , C07D413/14 , A61K31/536 , A61K31/551
CPC分类号: C07D413/14 , C07D413/02
摘要: The invention provides a novel class of compounds of formula (I), pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with abnormal or dysregulated B cell activities, particularly diseases or disorders that involve aberrant activation of inositol 1,4,5-trisphosphate 3-kinase B (ITPKb).
摘要翻译: 本发明提供了一类新颖的式(I)化合物,包含这些化合物的药物组合物和使用这些化合物治疗或预防与异常或失调B细胞活性相关的疾病或病症的方法,特别是涉及异常活化的疾病或病症 肌醇1,4,5-三磷酸3-激酶B(ITPKb)。
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24.
公开(公告)号:US07928133B2
公开(公告)日:2011-04-19
申请号:US12374739
申请日:2007-07-24
申请人: Dai Cheng , Dong Han , Wenqi Gao , Jiqing Jiang , Shifeng Pan , Yongqin Wan , Qihui Jin
发明人: Dai Cheng , Dong Han , Wenqi Gao , Jiqing Jiang , Shifeng Pan , Yongqin Wan , Qihui Jin
IPC分类号: A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/517 , A61K31/4709 , A61K31/454 , A61K31/4439 , A61K31/4375 , A61K31/428 , A61K31/427 , A61K31/423 , A61K31/422 , A61K31/4178 , A61K31/4164 , C07D471/04 , C07D417/14 , C07D413/14 , C07D413/12 , C07D405/12 , C07D401/12 , C07D403/12 , C07D401/14 , C07D233/64
CPC分类号: C07D413/14 , C07D233/64 , C07D401/12 , C07D471/04
摘要: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译: 本发明提供了一种调节刺猬蛋白信号通路活性的方法。 特别地,本发明提供了一种抑制由诸如Ptc功能丧失,hedgehog功能增益,平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法,包括使细胞接触 与足量的式I化合物反应。
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25.
公开(公告)号:US20090203666A1
公开(公告)日:2009-08-13
申请号:US12299290
申请日:2007-05-04
申请人: Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
发明人: Wenqi Gao , Jiqing Jiang , Yongqin Wan , Dai Cheng , Dong Han , Xu Wu , Shifeng Pan
IPC分类号: A61K31/55 , C07D265/30 , C07D401/04 , C07D267/10 , A61K31/5377 , A61K31/553 , A61P35/00
CPC分类号: C07C255/57 , C07C235/56 , C07C237/40 , C07C2601/14 , C07D413/04
摘要: The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.
摘要翻译: 本发明提供了一种调节刺猬蛋白信号通路活性的方法。 特别地,本发明提供了一种抑制由诸如Ptc功能丧失,hedgehog功能增益,平滑增益功能或Gli功能增益等表现形成的异常生长状态的方法,包括使细胞接触 与足量的式I化合物反应。
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