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33 条记录 (耗时 0.037 秒)

    Therapeutic And/Or Preventive Agents For Chronic Skin Diseases
    21.
    发明申请
    Therapeutic And/Or Preventive Agents For Chronic Skin Diseases 审中-公开
    慢性皮肤病的治疗和/或预防剂

    公开(公告)号：US20070287689A1

    公开(公告)日：2007-12-13

    申请号：US11576972

    申请日：2005-10-13

    申请人： Daisuke Harada ,  Katsuya Kobayashi ,  Haruhiko Manabe ,  Etsuo Ohshima

    发明人： Daisuke Harada ,  Katsuya Kobayashi ,  Haruhiko Manabe ,  Etsuo Ohshima

    IPC分类号： A61K31/56 ,  A61P17/00 ,  A61P17/06 ,  A61P17/08

    CPC分类号： A61K45/06 ,  A61K31/277 ,  A61K31/357 ,  A61K31/4409 ,  A61K31/4427 ,  A61K31/443 ,  A61K31/4433 ,  A61K31/496 ,  A61K31/573 ,  A61K31/58 ,  A61K2300/00

    摘要： The present invention provides: a therapeutic and/or preventive agent for chronic skin diseases which comprises (a) a phosphodiesterase (PDE)-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a steroid agent as active ingredients; a therapeutic and/or preventive agent for chronic skin diseases to be administered simultaneously or separately with an interval which comprises (a) a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a steroid agent, as active ingredients; a kit for treating and/or preventing chronic skin diseases characterized by comprising (a) a first component comprising a PDE-IV inhibitor or a pharmaceutically acceptable salt thereof and (b) a second component comprising a steroid agent; and the like.

    摘要翻译： 本发明提供：慢性皮肤病的治疗和/或预防剂，其包含（a）磷酸二酯酶（PDE）-IV抑制剂或其药学上可接受的盐和（b）作为活性成分的类固醇剂; 用于与（a）PDE-IV抑制剂或其药学上可接受的盐和（b）类固醇剂）作为活性成分的间隔同时或分开施用的慢性皮肤病的治疗和/或预防剂。 用于治疗和/或预防慢性皮肤疾病的试剂盒，其特征在于包含（a）包含PDE-IV抑制剂或其药学上可接受的盐的第一组分和（b）包含类固醇剂的第二组分; 等等。

    Pyrimidine derivatives
    25.
    发明申请
    Pyrimidine derivatives 审中-公开
    嘧啶衍生物

    公开(公告)号：US20060194811A1

    公开(公告)日：2006-08-31

    申请号：US10546215

    申请日：2004-02-20

    申请人： Etsuo Ohshima ,  Motoki Miyama ,  Koji Yanagawa ,  Seiji Aratake ,  Ichiro Miki ,  Katsuya Kobayashi

    发明人： Etsuo Ohshima ,  Motoki Miyama ,  Koji Yanagawa ,  Seiji Aratake ,  Ichiro Miki ,  Katsuya Kobayashi

    IPC分类号： A61K31/506 ,  C07D403/02

    CPC分类号： C07D401/04

    摘要： A pyrimidine derivative represented by Formula (I) wherein Ar represents substituted or unsubstituted aryl, R1 represents —NR2R3 and wherein R2 represents a hydrogen atom or substituted or unsubstituted lower alkyl and R3 represents substituted or unsubstituted lower alkyl, substituted or unsubstituted aralkyl, A represents a single bond, Formula (III) wherein m1 is 0 to 2, n1 is 0 to 4, a1 is from 0 to a substitutable number, R5 represents substituted or unsubstituted lower alkyl, and each R5 may be the same or different when a1 is 2 or more), and Q represents —NR6R7 (wherein R6 and R7 may be the same or different and each represents a hydrogen atom, a substituted or unsubstituted heteroalicyclic group, a substituted or unsubstituted heteroalicyclic group, substituted or unsubstituted piperidin-4-ylamino, or quaternary ammonium salts thereof, or pharmaceutically acceptable salts thereof.

    摘要翻译： 由式（I）表示的嘧啶衍生物，其中Ar表示取代或未取代的芳基，R 1表示-NR 2 R 3，并且其中R 1， O 2表示氢原子或取代或未取代的低级烷基，R 3表示取代或未取代的低级烷基，取代或未取代的芳烷基，A表示单键，式（III）其中 m 1是0至2，n 1是0至4，a 1是0至可取代数，R 5 代表取代或未取代的低级烷基，并且每个R 5可以相同或不同，当O 1为2或更多时），并且Q表示-NR 其中R 6和R 7可以相同或不同，并且各自表示氢原子， 取代或未取代的杂脂环基，取代或未取代的杂脂环基，取代或未取代的哌啶-4-基氨基或季铵 其盐或其药学上可接受的盐。