公开(公告)号：US20060166259A1

公开(公告)日：2006-07-27

申请号：US11390954

申请日：2006-03-28

申请人： Lydie Bougueleret ,  Bernard Bihain ,  Blake Denison ,  Frances Yen-Potin

发明人： Lydie Bougueleret ,  Bernard Bihain ,  Blake Denison ,  Frances Yen-Potin

IPC分类号： C12Q1/68 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  A01K2217/05 ,  C07K14/47 ,  C12Q2600/156 ,  Y10S977/928

摘要： The invention provides novel APM1 genomic sequences, polypeptides, antibodies, and polynucleotides including biallelic markers derived from the APM1 locus. Primers hybridizing to regions flanking these biallelic markers are also provided. This invention also provides polynucleotides and methods suitable for genotyping a nucleic acid containing sample for one or more biallelic markers of the invention. Additionally, the invention provides methods to detect a statistical correlation between a biallelic marker allele and a phenotype and/or between a biallelic marker haplotype and a phenotype. Further, the invention provides diagnostic methods for early detection of obesity-related disorders.

公开(公告)号：US06635431B1

公开(公告)日：2003-10-21

申请号：US09269939

申请日：1999-05-28

申请人： Bernard Bihain ,  Lydie Bougueleret ,  Frances Yen-Potin

发明人： Bernard Bihain ,  Lydie Bougueleret ,  Frances Yen-Potin

IPC分类号： C12N1512

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/715

摘要： The present invention relates to a new complex receptor polypeptide LSR (Lipolysis Stimulated Receptor), characterized by its functional activities, the cloning of the cDNAs complementary to the messenger RNAs encoding each of the subunits of the multimeric complex, vectors and transformed cells, methods of diagnosis and of selection of compounds which can be used as medicament for the prevention and/or treatment of pathologies and/or of pathogeneses such as obesity and anorexia, hyperlipidemias, atherosclerosis, diabetes, hypertension, and more generally the various pathologies associated with abnormalities in the metabolism of cytokines.

摘要翻译： 本发明涉及一种新的复合受体多肽LSR（Lipolysis Stimulated Receptor），其特征在于其功能活性，与编码多聚体复合物，载体和转化细胞的每个亚基的信使RNA互补的cDNA的克隆，方法 诊断和选择可用作预防和/或治疗病症和/或病原体如肥胖症和厌食症，高脂血症，动脉粥样硬化，糖尿病，高血压的药物的化合物，更一般地，与异常相关的各种病症 细胞因子的代谢。

公开(公告)号：US06344441B1

公开(公告)日：2002-02-05

申请号：US09485316

申请日：2000-02-04

申请人： Bernard Bihain ,  Lydie Bougueleret ,  Frances Yen-Potin

发明人： Bernard Bihain ,  Lydie Bougueleret ,  Frances Yen-Potin

IPC分类号： A16K3800

CPC分类号： C07K14/705 ,  A01K2217/05 ,  A61K38/00 ,  C07K14/715

摘要： Methods and pharmaceutical compositions useful for modulating lipoprotein levels in vivo. The invention stems from the discovery that activity of the Lipolysis Stimulated Receptor (LSR) can be inhibited or enhanced by exogenous agents, including polypeptides.

摘要翻译： 用于调节体内脂蛋白水平的方法和药物组合物。 本发明源自发现脂解作用受刺激受体（LSR）的活性可由外源试剂（包括多肽）抑制或增强。