公开(公告)号：US20120034212A1

公开(公告)日：2012-02-09

申请号：US13146278

申请日：2010-01-29

申请人： Michael Bowen ,  Herren Wu ,  William Dall' Acqua ,  Peter A. Kiener ,  Bahija Jallal ,  Anthony Coyle

发明人： Michael Bowen ,  Herren Wu ,  William Dall' Acqua ,  Peter A. Kiener ,  Bahija Jallal ,  Anthony Coyle

IPC分类号： A61K39/395 ,  C12N15/13 ,  C12N15/63 ,  C12N5/10 ,  C12N1/21 ,  C12N1/15 ,  C12N1/19 ,  A61P35/00 ,  A61P29/00 ,  A61P19/02 ,  A61P19/08 ,  A61P3/00 ,  A61P11/00 ,  A61P11/06 ,  A61P9/10 ,  C07K16/24

CPC分类号： C07K16/248 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/52 ,  C07K2317/56 ,  C07K2317/622 ,  C07K2317/72 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： The present invention provides human anti-IL-6 antibodies with extended in vivo half-life. The invention further relates to pharmaceutical compositions, therapeutic compositions, and methods using therapeutic antibodies that bind to IL-6 and that has an extended in vivo half-life for the treatment and prevention of IL-6 mediated diseases and disorders, such as, but not limited to, inflammatory diseases and disorders, autoimmune diseases and disorders and tumors.

摘要翻译： 本发明提供具有延长体内半衰期的人抗IL-6抗体。 本发明进一步涉及药物组合物，治疗组合物和使用结合IL-6的治疗性抗体并且具有延长的体内半衰期以用于治疗和预防IL-6介导的疾病和病症的方法，例如但是 不限于炎性疾病和病症，自身免疫疾病和病症和肿瘤。

公开(公告)号：US20080072189A1

公开(公告)日：2008-03-20

申请号：US11942270

申请日：2007-11-19

申请人： Michael Bowen ,  Alina Deutsch ,  Gerard Kopcsay ,  Byron Krauter ,  Barry Rubin ,  Howard Smith ,  David Widiger

发明人： Michael Bowen ,  Alina Deutsch ,  Gerard Kopcsay ,  Byron Krauter ,  Barry Rubin ,  Howard Smith ,  David Widiger

IPC分类号： G06F17/50

CPC分类号： G06F17/5036

摘要： An integrated circuit chip has new Frequency dependent RLC extraction and modeling providing on chip integrity and noise verification and the extraction and modeling employs: A) 2D scan line algorithm for the collection of adjacent signal and power conductor coordinates; B) In core pair-wise frequency Dependent RL extraction; C) In core equivalent circuit synthesis; D) caching and partitioning RL extraction techniques for run time efficiency; and E) Techniques for synthesizing stable circuits to represent frequency dependent RL circuits for non-mono tonic R12.

摘要翻译： 集成电路芯片具有新的频率相关RLC提取和建模，提供片上完整性和噪声验证，提取和建模采用：A）用于收集相邻信号和电源导线坐标的2D扫描线算法; B）在核心配对频率从属RL提取中; C）在核心等效电路合成中; D）缓存和分区RL提取技术，用于运行时效率; 和E）用于合成稳定电路以表示用于非单音增益R 12的频率相关RL电路的技术。

公开(公告)号：US07244573B2

公开(公告)日：2007-07-17

申请号：US10308279

申请日：2002-12-03

申请人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

发明人： Julie Carman ,  Steven G. Nadler ,  Michael Bowen ,  Michael G. Neubauer ,  Pin Lu

IPC分类号： G01N33/53 ,  G01N33/564 ,  C07H21/04

CPC分类号： C12Q1/6883 ,  C12Q2600/158

摘要： The present invention is directed to polynucleotides encoding polypeptides associated with the development of rheumatoid arthritis and homologs thereof. The invention further relates to diagnostic and therapeutic methods for utilizing these polynucleotides and polypeptides in the diagnosis, treatment, and/or prevention of rheumatoid arthritis and related disease states. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, and compounds identified thereby.

摘要翻译： 本发明涉及编码与类风湿性关节炎及其同系物相关的多肽的多核苷酸。 本发明还涉及在诊断，治疗和/或预防类风湿性关节炎和相关疾病状态中利用这些多核苷酸和多肽的诊断和治疗方法。 本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法，以及由此鉴定的化合物。

公开(公告)号：US20060201191A1

公开(公告)日：2006-09-14

申请号：US11421817

申请日：2006-06-02

申请人： MICHAEL BOWEN ,  LAWRENCE ERTZ ,  BRUCE KOPF ,  DEAN MARTIN ,  SCOTT LEIMKUEHLER ,  CHAD ROTTER

发明人： MICHAEL BOWEN ,  LAWRENCE ERTZ ,  BRUCE KOPF ,  DEAN MARTIN ,  SCOTT LEIMKUEHLER ,  CHAD ROTTER

IPC分类号： F25C5/18 ,  B67D5/62

CPC分类号： F25C5/005 ,  F25C5/18 ,  F25C5/20 ,  F25C5/22 ,  F25D23/028 ,  F25D23/126 ,  F25D27/00 ,  F25D31/002 ,  F25D2323/021 ,  F25D2327/001 ,  F25D2500/02

摘要： A refrigerator having an ice and water dispenser with a sloped dispensing cavity that extends upward and rearward from the refrigerator door. The dispenser design allows for more efficient use of storage space on the door behind the dispenser.

摘要翻译： 一种具有冰和水分配器的冰箱，其具有从冰箱门向上和向后延伸的倾斜分配腔。 分配器设计允许更有效地使用分配器后面的门上的存储空间。

公开(公告)号：US20060147974A1

公开(公告)日：2006-07-06

申请号：US11345126

申请日：2006-02-01

申请人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

发明人： Pamela Carroll ,  Jian Chen ,  Chandra Ramanathan ,  Hong Xiao ,  Bo Guan ,  Michael Bowen

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12P21/02 ,  C07K14/525 ,  C12N5/06

CPC分类号： C07K14/525 ,  A01K2217/05

摘要： The present invention provides novel polynucleotides encoding Drosophila DmTNF polypeptides, fragments and homologs thereof. The present invention also is directed to novel polynucleotides encoding two Drosophila DmTNF variants, DmTNFv1 and DmTNFv2 polypeptides, fragments and homologs thereof. Also provided are vectors, host cells, antibodies, and recombinant and synthetic methods for producing said polypeptides. The invention further relates to screening methods for identifying agonists and antagonists of the polynucleotides and polypeptides of the present invention, in addition to methods of genetically modifying Drosophila or cultured cells to express or mis-express DmTNF, DmTNFv1, or DmTNFv2. The invention also relates to the use of such modified insects or cells to characterize DmTNF activity, identify TNF-like genes and/or genes implicated in modulating TNF, characterize TNF signaling pathways, and/or to identify modulators of DmTNF activity.

摘要翻译： 本发明提供了编码果蝇DmTNF多肽的新型多核苷酸，其片段和同系物。 本发明还涉及编码两种果蝇DmTNF变体，DmTNFv1和DmTNFv2多肽的新型多核苷酸，其片段和同系物。 还提供了载体，宿主细胞，抗体以及用于产生所述多肽的重组和合成方法。 除了遗传修饰果蝇或培养细胞以表达或错误表达DmTNF，DmTNFv1或DmTNFv2的方法之外，本发明还涉及用于鉴定本发明的多核苷酸和多肽的激动剂和拮抗剂的筛选方法。 本发明还涉及这种修饰的昆虫或细胞用于表征DmTNF活性，鉴定涉及调节TNF，表征TNF信号传导途径和/或鉴定DmTNF活性调节剂的TNF-样基因和/或基因的用途。

公开(公告)号：US20060144075A1

公开(公告)日：2006-07-06

申请号：US11140096

申请日：2005-05-27

申请人： Michael Bowen ,  Lawrence Ertz ,  Bruce Kopf ,  Dean Martin ,  Scott Leimkuehler ,  Chad Rotter

发明人： Michael Bowen ,  Lawrence Ertz ,  Bruce Kopf ,  Dean Martin ,  Scott Leimkuehler ,  Chad Rotter

IPC分类号： B67D5/62 ,  F25C5/18 ,  F25D23/12

CPC分类号： F25C5/005 ,  F25C5/18 ,  F25C5/20 ,  F25C5/22 ,  F25D23/028 ,  F25D23/126 ,  F25D27/00 ,  F25D31/002 ,  F25D2323/021 ,  F25D2327/001 ,  F25D2500/02

摘要： A refrigerator having an ice and water dispenser that extends forwardly from the refrigerator door. The dispenser includes a retractable ledge to support a container, a sloped back wall to provide increased storage space in the door, a lighted target ring to facilitate positioning of a container for receipt of ice and water, an ice chute door actuated by an electric motor, and a seal to sealingly engage the ice compartment when the refrigerator door is closed.

摘要翻译： 具有从冰箱门向前延伸的冰和水分配器的冰箱。 分配器包括可收回的突出部以支撑容器，倾斜的后壁以提供增加的门的存储空间，用于有助于定位用于接收冰和水的容器的点火目标环，由电动机驱动的冰门 以及当冰箱门关闭时用于密封地接合冰室的密封件。

公开(公告)号：US20060059253A1

公开(公告)日：2006-03-16

申请号：US11238895

申请日：2005-09-29

申请人： Marina Goodman ,  Tor Mesoy ,  Stanton Taylor ,  Scott Reiter ,  Michael Bowen ,  Ralph Auriemma ,  Tamara Alairys ,  Christopher Degiorgio ,  Lizbeth Coleman

发明人： Marina Goodman ,  Tor Mesoy ,  Stanton Taylor ,  Scott Reiter ,  Michael Bowen ,  Ralph Auriemma ,  Tamara Alairys ,  Christopher Degiorgio ,  Lizbeth Coleman

IPC分类号： G06F15/173

CPC分类号： G06Q10/06 ,  G06F11/3409 ,  G06Q10/10

摘要： An execution architecture, a development architecture and an operations architecture for a netcentric computing system. The execution architecture contains common, run-time services required when an application executes in the netcentric computing system. The development architecture is the production environment for one or several systems development projects as well as for maintenance efforts. The purpose of the development environment is to support the tasks involved in the analysis, design, construction, and maintenance of business systems, as well as the associated management processes. It is important to note that the environment should adequately support all the development tasks, not just the code/compile/test/debug cycle. The operations architecture is a combination of tools and support services required to keep a production system up and running efficiently.

摘要翻译： 中心计算系统的执行架构，开发架构和操作架构。 执行架构包含应用程序在中心计算系统中执行时所需的常用的运行时服务。 开发架构是一个或多个系统开发项目的生产环境以及维护工作。 开发环境的目的是支持业务系统的分析，设计，构建和维护所涉及的任务以及相关的管理流程。 重要的是要注意，环境应该充分支持所有的开发任务，而不仅仅是代码/编译/测试/调试循环。 操作架构是保持生产系统高效运行所需的工具和支持服务的组合。

公开(公告)号：US20060041292A1

公开(公告)日：2006-02-23

申请号：US11196216

申请日：2005-08-03

申请人： Michael Bowen

发明人： Michael Bowen

IPC分类号： A61F7/00

CPC分类号： A61F7/10 ,  A61F2007/0098

摘要： An ice pack including a bag having a containment section with an opening. At least one layer of adhesive material and preferably two respective layers of adhesive material may be disposed on adjacent portions of the opening. At least one removable liner and preferably two removable liners may be disposed on respective layers of the adhesive material. The ice pack may be satisfactory for a single use.

摘要翻译： 一种冰袋，包括具有开口的容纳部分的袋子。 至少一层粘合剂材料，优选两层粘合剂材料可以设置在开口的相邻部分上。 至少一个可移除的衬垫和优选地两个可拆卸的衬垫可以设置在粘合材料的相应层上。 冰袋可以满足一次使用。

公开(公告)号：US20060041233A1

公开(公告)日：2006-02-23

申请号：US11196230

申请日：2005-08-03

申请人： Michael Bowen

发明人： Michael Bowen

IPC分类号： A61M5/32

CPC分类号： A61M25/02 ,  A61M2025/026

摘要： Apparatus and method to secure an appliance to a person is provided. The apparatus may have a base that attaches to a selected portion of a person's skin or other desired surface. A tongue may extend from the base and wrap around the appliance. At least a portion of the tongue may be alternately engaged with and disengaged from the tongue to accommodate securing and releasing the associated apparatus.

摘要翻译： 提供了将设备固定到人的装置和方法。 该装置可以具有附接到人的皮肤或其它期望表面的选定部分的基部。 舌头可以从基座延伸并包裹在器具上。 舌头的至少一部分可以交替地与舌头接合和脱开，以适应固定和释放相关联的装置。

公开(公告)号：US20050105745A1

公开(公告)日：2005-05-19

申请号：US10715343

申请日：2003-11-16

申请人： Michael Bowen ,  Michael Anderson

发明人： Michael Bowen ,  Michael Anderson

IPC分类号： H04R1/30 ,  H04R9/02 ,  H04R9/06 ,  H04R1/02

CPC分类号： H04R1/30 ,  H04R9/025 ,  H04R9/063

摘要： A practical and useful dual-element, or dual-cone, loudspeaker realizes a high efficiency of operation. Two preferably identical loudspeakers are placed back-to-back with their frontward openings facing in opposite directions, having no acoustical or mechanical connection between their movements. In the preferred embodiment, the back-to-back voice coils share a common permanent magnet. The back-to-back speaker assembly is mounted into a fixture in the center of two opposing horns, each containing an approximately 90-degree bend, approximately in the center of their lengths. The horns are acoustically independent and have approximately co-planar openings (as a result of the 90-degree corners) that project acoustical energy toward the same target. A distinct advantage due to the efficiency realized from this loudspeaker is a typical acoustical power gain of 11 dB with this approach vs. conventional speaker horn constructions. This power gain results in lower amplifier output power level requirements, hence reduced circuit costs and extended battery life in portable products.

摘要翻译： 实用和有用的双元件或双锥体扬声器实现高效率的操作。 两个优选地相同的扬声器被背对背放置，其前开口面向相反的方向，在其运动之间没有声学或机械连接。 在优选实施例中，背对背音圈共享公共永磁体。 背对背扬声器组件安装在两个相对的喇叭的中心的固定装置中，每个包含大约在其长度的中心的大约90度的弯曲部。 喇叭在声学上是独立的，并且具有将声能投射到相同目标的大致共面开口（作为90度角的结果）。 由于这种扬声器实现的效率所带来的显着优点是这种方法与常规扬声器喇叭结构相比，典型的声功率增益为11 dB。 该功率增益导致放大器输出功率电平要求较低，从而降低了便携式产品的电路成本和延长的电池寿命。