Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders
    22.
    发明申请
    Human G protein-coupled receptor and modulators thereof for the treatment of hyperglycemia and related disorders 审中-公开
    人G蛋白偶联受体及其调节剂用于治疗高血糖症和相关疾病

    公开(公告)号:US20070231263A1

    公开(公告)日:2007-10-04

    申请号:US11604178

    申请日:2006-11-22

    CPC classification number: C07D417/04 G01N2333/726 G01N2500/04 G01N2800/042

    Abstract: The present invention relates to methods of identifying whether one or more candidate compounds is a modulator of a G protein-coupled receptor (GPCR) or a modulator of blood glucose concentration. In certain embodiments, the GPCR is human. The present invention also relates to methods of using a modulator of the GPCR. A preferred modulator is agonist. Agonists of the invention are useful as therapeutic agents for lowering blood glucose concentration, for preventing or treating certain metabolic disorders, such as insulin resistance, impaired glucose tolerance, and diabetes, and for preventing or treating a complication of an elevated blood glucose concentration, such as atherosclerosis, heart disease, stroke, hypertension and peripheral vascular disease.

    Abstract translation: 本发明涉及鉴定一种或多种候选化合物是G蛋白偶联受体(GPCR)或血糖浓度调节剂的调节剂的方法。 在某些实施方案中,GPCR是人。 本发明还涉及使用GPCR的调制器的方法。 优选的调节剂是激动剂。 本发明的激动剂可用作降低血糖浓度的治疗剂,用于预防或治疗某些代谢紊乱,例如胰岛素抵抗,葡萄糖耐量异常和糖尿病,以及用于预防或治疗血糖浓度升高的并发症, 作为动脉粥样硬化,心脏病,中风,高血压和外周血管疾病。

    Adjustaclamp
    23.
    发明申请
    Adjustaclamp 审中-公开
    调节灯

    公开(公告)号:US20070108684A1

    公开(公告)日:2007-05-17

    申请号:US11280322

    申请日:2005-11-17

    Applicant: Robert Webb

    Inventor: Robert Webb

    CPC classification number: B25B5/163

    Abstract: A toggle clamp and spindle assembly. The spindle assembly can be adjusted both vertically and horizontally without the use of tools. A collar forms part of the spindle assembly and is mounted on the channel walls of the toggle clamp. A collar locking mechanism mounted fixes the horizontal position of the spindle assembly relative on the channel walls. An upper end adjustment handle fixed to the spindle is used to vertically adjust the position of the spindle and a lower work piece engaging grommet.

    Abstract translation: 肘杆和主轴总成。 主轴组件可以垂直和水平调节,无需使用工具。 轴环形成主轴组件的一部分,并安装在肘节夹的通道壁上。 安装的套环锁定机构相对于通道壁固定主轴组件的水平位置。 固定在主轴上的上端调节手柄用于垂直调节主轴的位置和下部工件与索环的接合。

    Compounds for intracellular delivery of therapeutic moieties to nerve cells
    25.
    发明申请
    Compounds for intracellular delivery of therapeutic moieties to nerve cells 有权
    将治疗性部分细胞内递送给神经细胞的化合物

    公开(公告)号:US20050260211A1

    公开(公告)日:2005-11-24

    申请号:US10652723

    申请日:2003-08-28

    CPC classification number: A61K47/6807 A61K47/6425 Y10T436/21

    Abstract: A compound for delivering a non-cytotoxic therapeutic moiety into nerve cells, the compound having the general formula: B-L-TM where: B is a binding agent capable of selectively binding to a nerve cell surface receptor and mediating absorption of the compound by the nerve cell; TM is a therapeutic moiety which has a non-cytotoxic therapeutic effect when absorbed by a nerve cell; and L is a linker coupling B to TM.

    Abstract translation: 用于将非细胞毒性治疗部分递送至神经细胞的化合物,具有以下通式的化合物:<?in-line-formula description =“In-line Formulas”end =“lead”?> BL-TM < line-formula description =“In-line Formulas”end =“tail”?>其中:B是能够选择性地结合神经细胞表面受体并介导神经细胞吸收化合物的结合剂; TM是当被神经细胞吸收时具有非细胞毒性治疗作用的治疗部分; L是连接B到TM的接头。

    Video signal processing
    26.
    发明授权
    Video signal processing 失效
    视频信号处理

    公开(公告)号:US06570923B2

    公开(公告)日:2003-05-27

    申请号:US09727286

    申请日:2000-11-30

    CPC classification number: H04N19/40 H04N19/51 H04N21/431

    Abstract: Video signal processing apparatus in which at least first and second input video signals are combined to generate an output compressed video signal, the first and second video signals each having respective associated motion vectors from a data compression process applied to the video signals; comprises: means for establishing a set of the motion vectors associated with the first and second video signals which can potentially be re-used in compressing the output compressed video signal; and means for testing the set of motion vectors, the testing means being operable: (c) to define, with respect to reference images referred to by the motion vectors under test, a first border region of a predetermined width surrounding those parts of the reference images derived in part from the first video signal, and a second border region of a predetermined width surrounding those parts of the reference images derived in part from the second video signal; and (d) to test whether motion vectors of the set which are associated with parts of each video signal refer either to image areas derived in part from the other video signal, to the first border region or to the second border region; in which any motion vectors of the set being found by the testing means to refer to images areas derived to at least the predetermined degree from the other input video signal, the first border region or the second border region are not used in the compression of the output compressed video signal.

    Abstract translation: 视频信号处理装置,其中组合至少第一和第二输入视频信号以产生输出压缩视频信号,所述第一和第二视频信号各自具有来自应用于视频信号的数据压缩处理的相应的相关联的运动矢量; 包括:用于建立与第一和第二视频信号相关联的一组运动矢量的装置,其可以潜在地在压缩输出压缩视频信号中被重新使用; 以及用于测试所述运动矢量集合的方法,所述测试装置可操作:(c)相对于被测运动矢量所参考的参考图像来定义围绕参考图像的那些部分的预定宽度的第一边界区域 部分地从第一视频信号导出,以及围绕部分地从第二视频信号导出的参考图像的那些部分的预定宽度的第二边界区域; 和(d)测试与每个视频信号的部分相关联的集合的运动矢量是否指向从另一视频信号部分导出的图像区域到第一边界区域或第二边界区域;其中任何 由测试装置找到的集合的运动矢量指的是从另一输入视频信号至少导出预定程度的图像区域,第一边界区域或第二边界区域不用于压缩输出压缩视频 信号。

    Laser bonding technique and article formed thereby
    27.
    发明授权
    Laser bonding technique and article formed thereby 失效
    激光焊接技术和由此形成的物品

    公开(公告)号:US4320281A

    公开(公告)日:1982-03-16

    申请号:US174052

    申请日:1980-07-31

    CPC classification number: H01G4/228 B23K1/0056 H01G2/14 B23K2201/38

    Abstract: Electrically conductive leads (12) are bonded to pre-tinned ends (11) of a thin film, rolled capacitor (10). A dimple (20) is formed in the leads (12) resulting in an indentation (21) therein and a protrusion (22) on the opposite surface thereof. The protrusion (22) is placed in contact with the end (11) and a pulsed laser beam directed into the indentation (21) to heat the lead (12) in the vicinity of the protrusion (22) to reflow a portion of the pre-tinned ends (11) to form a bond therebetween.

    Abstract translation: 导电引线(12)接合到薄膜,卷绕电容器(10)的预镀锡端(11)。 在引线(12)中形成凹坑(20),导致凹陷(21)和在其相对表面上的突起(22)。 突起(22)被放置成与端部(11)接触,并且脉冲激光束被引导到凹部(21)中,以在突起(22)附近加热引线(12)以回流预先的一部分 (11)以在它们之间形成结合。

    Combination mirror/hair dryer
    28.
    发明授权
    Combination mirror/hair dryer 失效
    组合镜/吹风机

    公开(公告)号:US4161955A

    公开(公告)日:1979-07-24

    申请号:US805531

    申请日:1977-06-10

    Applicant: Robert Webb

    Inventor: Robert Webb

    CPC classification number: A45D44/06 A45D20/08 A45D42/00

    Abstract: A custom grooming device has relatively opposing mirrors mounted on a base. A portable pistol-type hair dryer is mountable on the base; air from the dryer flows through a hose to an exhaust port located near one of the mirrors. The mirrors are adjustable in height and angle for viewing all parts of the head.

    Abstract translation: 定制的梳妆装置具有安装在基座上的相对相对的镜子。 便携式手枪型吹风机可安装在底座上; 来自干衣机的空气通过软管流到位于一个反射镜附近的排气口。 镜子的高度和角度可调,用于观察头部的所有部分。

    Vaccine for avian influenza and methods of use
    29.
    发明授权
    Vaccine for avian influenza and methods of use 有权
    禽流感疫苗及使用方法

    公开(公告)号:US07993655B2

    公开(公告)日:2011-08-09

    申请号:US12296729

    申请日:2007-04-20

    Abstract: The subject invention pertains to influenza vaccines and particularly avian influenza vaccines (AIV). The invention includes methods for preparing transgenic plant cells to express know HA1 polypeptides having specified homologies that are used to prepare vaccine compositions and methods for inducing protective immunity in an individual, animal, mammal or human.

    Abstract translation: 本发明涉及流感疫苗,特别是禽流感疫苗(AIV)。 本发明包括用于制备转基因植物细胞以表达具有用于制备疫苗组合物的具有特定同源性的已知HA1多肽的方法和在个体,动物,哺乳动物或人中诱导保护性免疫的方法。

    Device and method for wide-field and high resolution imaging of tissue
    30.
    发明申请
    Device and method for wide-field and high resolution imaging of tissue 有权
    用于组织的广域和高分辨率成像的装置和方法

    公开(公告)号:US20080024860A1

    公开(公告)日:2008-01-31

    申请号:US11823610

    申请日:2007-06-28

    CPC classification number: G02B21/0024 A61B5/0068 A61B5/0071 A61B5/444

    Abstract: A device for wide-field and high resolution imaging of an object surface includes first and second imaging modalities, a lens associated with the second imaging modality. The first imaging modality has a high resolution imaging means with a first observation line. The second imaging modality is arranged in an image plane at a first angle with respect to an object plane and has a second observation line and a wider imaging field than the first imaging modality. The lens associated with the second imaging modality is arranged in a lens plane at a second angle with respect to the object plane, where the second angle being equal to about one-half of the first angle. The first and second imaging modalities are mutually arranged such that the first and second optical axes intersect at a point on the object plane.

    Abstract translation: 用于物体表面的广域和高分辨率成像的装置包括第一和第二成像模态,与第二成像模态相关联的透镜。 第一成像模式具有具有第一观察线的高分辨率成像装置。 第二成像模式相对于物体平面以第一角度布置在图像平面中,并且具有比第一成像模态更多的第二观察线和更宽的成像场。 与第二成像模态相关联的透镜相对于物平面以第二角度布置在透镜平面中,其中第二角度等于第一角度的大约二分之一。 第一和第二成像模式被相互布置,使得第一和第二光轴在物平面上的点处相交。

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