公开(公告)号：US20120107909A1

公开(公告)日：2012-05-03

申请号：US13129282

申请日：2009-11-13

申请人： Stephen M. Smith ,  Preston A. Marx

发明人： Stephen M. Smith ,  Preston A. Marx

IPC分类号： C12N7/00 ,  C12N7/01

CPC分类号： C07K16/1045 ,  C12N7/00 ,  C12N2740/16021 ,  C12Q1/703 ,  C12Q2600/112 ,  G01N33/56988 ,  G01N2333/16 ,  G01N2469/20

摘要： The invention provides a novel strain of HIV-2 capable of causing immunodeficiency. The invention also provides compositions comprising the nucleic acids and polypeptides characteristic of this HIV-2 virus, antibodies specific for this HIV-2 virus, methods of using these compositions, and methods of detecting HIV-2 virus.

摘要翻译： 本发明提供了能够引起免疫缺陷的新型HIV-2菌株。 本发明还提供了包含该HIV-2病毒特征的核酸和多肽的组合物，对该HIV-2病毒特异的抗体，使用这些组合物的方法和检测HIV-2病毒的方法。

公开(公告)号：US20080308588A1

公开(公告)日：2008-12-18

申请号：US11763675

申请日：2007-06-15

申请人： Stephen M. Smith ,  Theron Shaw ,  Christopher J. Duke ,  Terence P. Grace ,  Michael R. Uhlmeyer ,  Stephen D. Logan ,  David M. Langer

发明人： Stephen M. Smith ,  Theron Shaw ,  Christopher J. Duke ,  Terence P. Grace ,  Michael R. Uhlmeyer ,  Stephen D. Logan ,  David M. Langer

IPC分类号： B62D43/02

CPC分类号： B62D43/02 ,  B60Q1/2661

摘要： A spare tire carrier for a vehicle may structurally entail a base, a mounting flange extending from the base, a vertical support post extending from the base, a light support post attached to the vertical support post, a threaded stud that engages a front surface of the base to support a spare tire. A tether, which may be secured to the base with a fastener, may lie largely concealed within the base and have additional studs or bolts which may protrude through a front surface of the base and further support a spare tire. A plurality of strength ribs may join the mounting flange and the base, while the base, the first mounting flange, vertical support post extending from the base, and plurality of strength ribs may be a single cast magnesium part. The tether may be of another high strength material.

摘要翻译： 用于车辆的备用轮胎载体可以在结构上涉及基座，从基座延伸的安装凸缘，从基座延伸的垂直支撑柱，附接到垂直支撑柱的光支撑柱，与螺栓的前表面接合的螺柱 基地支持备胎。 可以用紧固件固定到基座的系绳可能大部分隐藏在基座内，并且具有附加的螺柱或螺栓，其可以突出穿过基座的前表面并进一步支撑备用轮胎。 多个加强肋可以连接安装凸缘和基座，而基部，第一安装凸缘，从基部延伸的垂直支撑柱，以及多个强化肋可以是单个铸造的镁部件。 系绳可能是另一种高强度材料。

公开(公告)号：US07087122B2

公开(公告)日：2006-08-08

申请号：US11005754

申请日：2004-12-06

申请人： Stephen M. Smith ,  Randolph E. Treur

发明人： Stephen M. Smith ,  Randolph E. Treur

IPC分类号： B08B7/00 ,  C23F1/00

CPC分类号： H01L21/68728 ,  H01L21/68785 ,  H01L21/68792

摘要： A method for spinning a wafer to enable rinsing and drying is provided. The method includes engaging the wafer at a wafer processing plane and spinning the wafer. The method further includes moving a wafer backside plate from a first position to a second position as spinning of the wafer proceeds to an optimum spinning speed. The second position defines a reduced gap between an under surface of the wafer and a top surface of the wafer backside plate. The method also includes repositioning the wafer backside plate from the second position to the first position as the spinning reduces in speed. The first position defines an enlarged gap to enable loading and unloading of the wafer from the engaged position.

摘要翻译： 提供了一种用于纺丝晶片以实现冲洗和干燥的方法。 该方法包括使晶片在晶片处理平面处接合并旋转晶片。 该方法还包括当晶片的旋转进行到最佳旋转速度时，将晶片背面板从第一位置移动到第二位置。 第二位置限定晶片的下表面和晶片背面板的顶表面之间的减小的间隙。 该方法还包括当旋转速度降低时将晶片背面板从第二位置重新定位到第一位置。 第一位置限定了扩大的间隙，以使晶片能够从接合位置加载和卸载。

公开(公告)号：US06827092B1

公开(公告)日：2004-12-07

申请号：US09747660

申请日：2000-12-22

申请人： Stephen M. Smith ,  Randolph E. Treur

发明人： Stephen M. Smith ,  Randolph E. Treur

IPC分类号： B08B300

CPC分类号： H01L21/68728 ,  H01L21/68785 ,  H01L21/68792

摘要： An apparatus for preparing a wafer is provided. The apparatus includes a wafer backside plate and a central shaft. The wafer backside plate has a top surface that includes a cylindrical edge lip, which defines a central aperture. The central shaft is designed to fit within the central aperture. The wafer backside plate is designed to automatically slide between an up position during rotational wager processing and a down position when the wafer is not in rotational wafer processing. A gap defined between the top surface of the wafer backside plate and the wafer is less when the wafer backside plate is in the up position than when the wafer backside plate is in the down position.

摘要翻译： 提供了一种用于制备晶片的装置。 该装置包括晶片背面板和中心轴。 晶片背面板具有顶表面，其包括限定中心孔的圆柱形边缘。 中心轴设计成适合中心孔。 晶片背面板被设计成在旋转下注处理期间的上升位置和当晶片不处于旋转晶片处理时的向下位置之间自动滑动。 当晶片背面板处于向上位置时，当晶片背面板处于向下位置时，在晶片背面板的顶表面和晶片之间限定的间隙较小。

公开(公告)号：US06578853B1

公开(公告)日：2003-06-17

申请号：US09747665

申请日：2000-12-22

申请人： Randolph E. Treur ,  Stephen M. Smith

发明人： Randolph E. Treur ,  Stephen M. Smith

IPC分类号： H01L21304

CPC分类号： H01L21/68728 ,  G03F7/3021 ,  H01L21/68785 ,  H01L21/68792 ,  Y10S134/902 ,  Y10T279/185 ,  Y10T279/1973

摘要： A chuck assembly for use in a substrate spin, rinse, and dry (SRD) module is provided. The chuck assembly includes a wedge, a chuck body, and a plurality of grippers. The wedge has a sidewall and is designed to move from a lower position to an upper position and from the upper position to the lower position thus opening and closing the chuck assembly, respectively. The chuck body has a cylindrical shape and is designed to include a plurality of linkage arms. The chuck body is designed to enclose the wedge such that each linkage arm is substantially in contact with the sidewall of the wedge. The cylindrical shape of the chuck body is designed to reduce air disturbance around a surface of a substrate. The plurality of grippers are designed to be coupled to the chuck body via a plurality of rotation pins. Each of the grippers is configured to stand substantially upright so as to engage the substrate when the wedge is in a lower position, and each of the grippers is configured to lie substantially flat so as to disengage the substrate when the wedge is in the lower position.

摘要翻译： 提供了一种用于衬底旋转，冲洗和干燥（SRD）模块的卡盘组件。 卡盘组件包括楔形物，卡盘主体和多个夹具。 楔形件具有侧壁并且被设计成从下部位置移动到上部位置并且从上部位置移动到下部位置，从而分别打开和关闭卡盘组件。 卡盘体具有圆筒形状并且被设计成包括多个连杆臂。 卡盘体被设计成围绕楔形物，使得每个连杆臂基本上与楔形物的侧壁接触。 卡盘体的圆柱形被设计成减小基体表面周围的空气扰动。 多个夹持器被设计成经由多个旋转销耦合到卡盘主体。 每个夹持器构造成基本上竖直地站立，以便当楔形件处于较低位置时接合基板，并且每个夹具构造成基本上平坦，以便当楔形件处于较低位置时使基板脱离 。

公开(公告)号：US06521739B1

公开(公告)日：2003-02-18

申请号：US09206551

申请日：1998-12-07

申请人： Beatrice H. Hahn ,  Feng Gao ,  George M. Shaw ,  Preston A. Marx ,  Stephen M. Smith ,  Marie Claude Georges-Courbot ,  Chang Yong Lu

发明人： Beatrice H. Hahn ,  Feng Gao ,  George M. Shaw ,  Preston A. Marx ,  Stephen M. Smith ,  Marie Claude Georges-Courbot ,  Chang Yong Lu

IPC分类号： A61K3800

CPC分类号： C07K14/005 ,  A61K2039/53 ,  C12N7/00 ,  C12N2740/15021 ,  C12N2740/15022

摘要： The nucleotide sequence and deduced amino acid sequences of the complete genome of a simian immunodeficiency virus isolate from a red-capped mangabey are disclosed. The invention relates to the nucleic acids and peptides encoded by and/or derived from these sequences and their use in diagnostic methods and as immunogens.

公开(公告)号：US08292729B2

公开(公告)日：2012-10-23

申请号：US10727154

申请日：2003-12-02

申请人： Kenneth A. Vlazny ,  Scott B. Pfennighausen ,  Stephen M. Smith ,  Joseph J. Tracy ,  Victor I. Harrison

发明人： Kenneth A. Vlazny ,  Scott B. Pfennighausen ,  Stephen M. Smith ,  Joseph J. Tracy ,  Victor I. Harrison

IPC分类号： A63F9/24

CPC分类号： G07F17/32 ,  G07F17/3288

摘要： Methods and systems of pari-mutuel wagering are disclosed to facilitate the wager construction process. In one method, patrons select runners, and betting options of selected runners are presented. In another method, a first wager is placed and other wagers are presented, wherein the additional wagers may include a runner of the first wager. Another method allows patrons to wager on a runner, wherein an area representing the runner is marked to indicate that this runner was selected on a previous wager or in the current wager. In another method, a portion of a wager is patron selected and a portion of the wager is suggested by the betting interface. In another method, patrons may construct wager(s) for single or future races, or specify criteria for those wagers. In another method, runners are displayed in a table and patrons may select or deselect runner combinations by selecting cells within the table. Methods and systems of pari-mutuel wagering that enable an organization to set rules to display the gaming activity, and an embodiment where players make subscription as well as programmed bets are described.

摘要翻译： 公开了同时投注的方法和系统，以便于下注建设过程。 在一种方法中，顾客选择跑步者，并且呈现所选跑步者的投注选项。 在另一种方法中，放置第一投注和呈现其他投注，其中附加投注可以包括第一投注者的转牌。 另一种方法允许顾客在跑步者上投注，其中代表跑步者的区域被标记以指示在以前的下注或当前下注中选择了该选手。 在另一种方法中，投注的一部分被选中，并且投注的一部分由投注界面建议。 在另一种方法中，顾客可以为单一或未来的种族构建投注，或者为这些投注规定标准。 在另一种方法中，跑步者显示在表中，顾客可以通过选择表中的单元格来选择或取消选择赛跑者组合。 描述了使组织能够设置显示游戏活动的规则的同步赌注的方法和系统，以及玩家进行订阅以及编程赌注的实施例。

公开(公告)号：US20090028679A1

公开(公告)日：2009-01-29

申请号：US12171522

申请日：2008-07-11

申请人： Stephen M. Smith

发明人： Stephen M. Smith

IPC分类号： B60P9/00

CPC分类号： B60P1/4421 ,  B60R9/06 ,  B66F9/06 ,  B66F9/075 ,  B66F9/12

摘要： A load transport device that mounts to a vehicle mounted trailer hitch. The load transport system comprises a channel portion fitted with a pinion gear, and the channel portion is rigidly attached to a mounting bar that slideably engages a receiver portion of a vehicle's trailer hitch. The device also comprises an invertible shaft with an optionally-motorized rack gear system. The invertible shaft has a channel portion insertion end and a load lifting end. The invertible shaft slideably engages in either a load-low or load-high orientation depending on which end, the insertion end or the load lifting end first engages with the channel portion. The pinion gear and the rack gear system are functionally engaged. The load transport device further comprises a load support member attached to the load lifting end and comprising one or more bars that support a load.

摘要翻译： 一种装载到车辆挂车挂车上的装载运输装置。 负载传送系统包括配有小齿轮的通道部分，并且通道部分刚性地附接到可滑动地接合车辆拖车挂钩的接收器部分的安装杆。 该装置还包括具有任选地机动的齿条系统的可逆轴。 可逆轴具有通道部分插入端和负载提升端。 可逆轴可滑动地接合负载低或负载高的方向，取决于该端，插入端或负载提升端首先与通道部分接合。 小齿轮和齿条系统功能接合。 负载传送装置还包括附接到负载提升端并且包括支撑负载的一个或多个杆的负载支撑构件。

公开(公告)号：US07040017B2

公开(公告)日：2006-05-09

申请号：US10251483

申请日：2002-09-19

申请人： Stephen M. Smith ,  Randolph E. Treur

发明人： Stephen M. Smith ,  Randolph E. Treur

IPC分类号： B21K21/08 ,  B05B1/14

CPC分类号： H01L21/67051 ,  B08B3/02 ,  Y10S134/902 ,  Y10T29/49432 ,  Y10T29/49433

摘要： A fluid delivery module for use in preparing a substrate is provided. The fluid delivery module includes a process bowl designed to contain a substrate to be prepared. The process bowl has a bottom wall and a sidewall. The fluid delivery module further includes a fluid delivery ring configured to be attached to the sidewall of the process bowl. The fluid delivery ring includes a plurality of inlet and outlet pairs. Each of the plurality of inlet and outlet pairs is defined in the fluid ring and is designed to receive a respective supply tube. Each respective supply tube has an end that terminates at each of the outlets of the fluid delivery ring and is configured to direct fluid onto a surface of the substrate.

摘要翻译： 提供了一种用于制备基板的流体输送模块。 流体输送模块包括设计成容纳要制备的基底的处理碗。 处理碗具有底壁和侧壁。 流体输送模块还包括流体输送环，该流体输送环被配置为附接到处理碗的侧壁。 流体输送环包括多个入口和出口对。 多个入口和出口对中的每一个限定在流体环中并且被设计成容纳相应的供给管。 每个相应的供应管具有终止于流体输送环的每个出口处的端部，并且构造成将流体引导到基板的表面上。

公开(公告)号：US06541003B1

公开(公告)日：2003-04-01

申请号：US09624964

申请日：2000-07-25

申请人： Stephen M. Smith

发明人： Stephen M. Smith

IPC分类号： A61K3921

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  C12N7/00 ,  C12N15/85 ,  C12N2740/16022 ,  C12N2740/16034 ,  C12N2740/16043 ,  C12N2740/16051 ,  C12N2830/003

摘要： A live attenuated human immunodeficiency virus type 1 (HIV-1) whose replication is not constitutive but is instead conditionally regulated (such that rounds of reverse transcription with accompanying potential for error are strictly limited) might yield a paradigm that minimizes evolution to virulence and facilitate vaccine development. We have broached the concept of conditional control of HIV-1 through gain-of-function. Here, we describe the design of constitutively inactive HIV-1 genomes (HIV-DoxT and HIV-DoxSp) which can be conditionally resuscitated to an active state by tetracycline or related analogues. The HIV-DoxT construct comprises an inactivating mutation engineered into TAR, thereby rendering the virus non-responsive to Tat, a 302-bp DNA fragment (TetopT) which contains the tet-operator ligated into a position upstream of the HIV TATAA box, in both the 5′ and 3′ LTRs, and a reverse tetracycline-controlled activator (RTTA) coding sequence in place of the nef coding region. The HIV-DoxSp construct contains three additional Sp1 sites in the TetopT promoter upstream of the TATAA box thereby generating the promoter TetopSp. Genotypically, HIVDoxT is tat(+)tar(−)nef(−)Sp1(−) and HIVDoxSp is tat(+)tar(−)nef(−)Sp1(+). Since both genomes are genetically tar(−), they would ordinarily be expected to be wholly defective in producing viral proteins and/or particles. However, following transfection into an appropriate cell target, both proviruses, in a doxycycline-dependent fashion, capably released Gag and RT from cells. In the absence of doxycycline, no replication competent virus could be recovered. These findings suggest that the heterologous RTTA+Dox mechanism substituted effectively for Tat/TAR. These constructs should prove useful in the development of HIV-specific immunological and diagnostic reagents.

摘要翻译： 一种减毒的人类免疫缺陷病毒1型（HIV-1），其复制不是组成型的，而是有条件地调节（使得具有伴随的误差潜力的逆转录循环被严格限制）可能产生使进化为毒力最小化的方式 疫苗开发。 我们通过功能增强来阐述了有条件地控制艾滋病毒1的概念。 在这里，我们描述了组成型无活性的HIV-1基因组（HIV-DoxT和HIV-DoxSp）的设计，其可以通过四环素或相关类似物有条件地复苏为活性状态。 HIV-DoxT构建体包含工程化成TAR的失活突变体，从而使病毒对Tat具有不敏感性，Tat是一种302bp的DNA片段（TetopT），其包含连接到HIV TATAA盒上游位置的tet操纵子， 5'和3'LTR以及反向四环素控制的激活子（RTTA）编码序列代替nef编码区。 HIV-DoxSp构建体在TATAA盒上游的TetopT启动子中含有三个额外的Sp1位点，从而产生启动子TetopSp。 基因型，HIVDoxT是tat（+）焦油（ - ）nef（ - ）Sp1（ - ）和HIVDoxSp是tat（+）焦油（ - ）nef（ - ）Sp1（+）。 由于两种基因组都是基因型焦油（ - ），因此通常预计在产生病毒蛋白和/或颗粒方面完全缺陷。 然而，在转染到合适的细胞靶之后，两种前病毒以强力霉素依赖的方式从细胞中有效释放Gag和RT。 在没有多西环素的情况下，不能恢复可复制的病毒。 这些发现表明异源RTTA + Dox机制有效地替代了Tat / TAR。 这些构建体在HIV特异性免疫和诊断试剂的开发中应该是有用的。