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    Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines
    22.
    发明申请
    Production of attenuated, human-bovine chimeric respiratory syncytial virus vaccines 失效
    减毒，人 - 牛嵌合呼吸道合胞体病毒疫苗的生产

    公开(公告)号：US20070184069A1

    公开(公告)日：2007-08-09

    申请号：US11203620

    申请日：2005-08-11

    Applicant: Ursula Buchholz ,  Peter Collins ,  Brian Murphy ,  Stephen Whitehead ,  Christine Krempl

    Inventor： Ursula Buchholz ,  Peter Collins ,  Brian Murphy ,  Stephen Whitehead ,  Christine Krempl

    IPC: A61K39/155 ,  C07H21/04 ,  C12N7/00 ,  C12N15/86

    CPC classification number: C12N7/00 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/544 ,  C07K14/005 ,  C07K2319/00 ,  C12N15/86 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18543 ,  C12N2760/18561 ,  C12N2840/203

    Abstract: Chimeric human-bovine respiratory syncytial virus (RSV) are infectious and attenuated in humans and other mammals and useful in vaccine formulations for eliciting an anti-RSV immune response. Also provided are isolated polynucleotide molecules and vectors incorporating a chimeric RSV genome or antigenome which includes a partial or complete human or bovine RSV “background” genome or antigenome combined or integrated with one or more heterologous gene(s) or genome segment(s) of a different RSV strain. Chimeric human-bovine RSV of the invention include a partial or complete “background” RSV genome or antigenome derived from or patterned after a human or bovine RSV strain or subgroup virus combined with one or more heterologous gene(s) or genome segment(s) of a different RSV strain or subgroup virus to form the human-bovine chimeric RSV genome or antigenome. In preferred aspects of the invention, chimeric RSV incorporate a partial or complete bovine RSV background genome or antigenome combined with one or more heterologous gene(s) or genome segment(s) from a human RSV. Genes of interest include any of the NS1, NS2, N, P, M, SH, M2(ORF1), M2(ORF2), L, F or G genes or a genome segment including a protein or portion thereof. A variety of additional mutations and nucleotide modifications are provided within the human-bovine chimeric RSV of the invention to yield desired phenotypic and structural effects.

    Abstract translation: 嵌合人 - 牛呼吸道合胞病毒（RSV）在人类和其他哺乳动物中具有感染性和减毒性，并且可用于引发抗RSV免疫应答的疫苗制剂中。 还提供了分离的多核苷酸分子和掺入嵌合RSV基因组或抗原组的载体，其包括部分或完整的人或牛RSV“背景”基因组或与一个或多个异源基因或基因组片段 不同的RSV菌株。 本发明的嵌合人类牛RSV包括部分或完整的“背景”RSV基因组或在与一个或多个异源基因或基因组片段组合的人或牛RSV病毒株或亚组病毒之后衍生或构图的部分或完整的“背景” 的不同RSV株或亚组病毒形成人 - 牛嵌合RSV基因组或抗原组。 在本发明的优选方面，嵌合RSV包含与来自人RSV的一个或多个异源基因或基因组片段组合的部分或完整的牛RSV背景基因组或反义基因组。 感兴趣的基因包括任何NS1，NS2，N，P，M，SH，M2（ORF1），M2（ORF2），L，F或G基因或包含蛋白质或其部分的基因组片段。 在本发明的人 - 牛嵌合RSV内提供了多种额外的突变和核苷酸修饰，以产生所需的表型和结构效果。

    Hose reel cart with multi-position crank handle
    28.
    发明授权
    Hose reel cart with multi-position crank handle 有权
    带多功能手柄的软管卷盘车

    公开(公告)号：US07959101B2

    公开(公告)日：2011-06-14

    申请号：US12341827

    申请日：2008-12-22

    Applicant: Stephen Whitehead ,  Michael Thuma ,  Michael Uffner ,  Matthew McKimmy ,  Michael R. Vogler

    Inventor： Stephen Whitehead ,  Michael Thuma ,  Michael Uffner ,  Matthew McKimmy ,  Michael R. Vogler

    IPC: B65H75/30

    CPC classification number: B65H75/40 ,  B65H75/4407 ,  B65H75/4465 ,  B65H75/4471 ,  B65H75/4492 ,  B65H2402/412 ,  B65H2701/33 ,  Y10T137/6954

    Abstract: The present invention relates to hose reel carts for handling and storage of flexible hoses, such as garden or air hoses. The hose reel cart is primarily constructed of plastic components having a centrally rotatable spool for winding of the flexible hose, a frame for supporting the spool and a multi-position crank arm assembly allowing the consumer to place the crank handle in a lowered position or a raised position. The crank remotely drives the spool, for winding the hose, through a series of gears located within the crank arm assembly. The device may further include a reciprocating guide assembly that operates during rotation of the spool to rewind the hose into a compact configuration.

    Abstract translation: 本发明涉及用于处理和储存诸如花园或空气软管的柔性软管的软管卷轴车。 软管卷盘车主要由塑料部件构成，该塑料部件具有用于缠绕柔性软管的可中心旋转的卷轴，用于支撑卷轴的框架和多位置的曲柄臂组件，其允许消费者将曲柄手柄放置在降低的位置或 提高职位 曲柄通过位于曲柄臂组件内的一系列齿轮远程地驱动滑阀，用于卷绕软管。 该装置可以进一步包括往复式导向组件，该往复导向组件在卷轴的旋转期间操作以将软管重新卷成紧凑的构造。

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