公开(公告)号：US20150209485A1

公开(公告)日：2015-07-30

申请号：US14677741

申请日：2015-04-02

申请人： Dadong ZHANG ,  Xu CAI ,  Chengyun YUE ,  Junfei LI ,  Yan HU ,  Peng HUANG ,  Zhirong TANG ,  Qiyi LUO

发明人： Dadong ZHANG ,  Xu CAI ,  Chengyun YUE ,  Junfei LI ,  Yan HU ,  Peng HUANG ,  Zhirong TANG ,  Qiyi LUO

IPC分类号： A61L31/10 ,  A61L31/16

CPC分类号： A61L31/10 ,  A61F2/82 ,  A61F2250/0067 ,  A61F2250/0068 ,  A61L31/146 ,  A61L31/16 ,  A61L2300/416 ,  A61L2420/02 ,  C08L75/04 ,  C08L67/04 ,  C08L89/00 ,  C08L33/10 ,  C08L5/08

摘要： An interventional medical device and manufacturing method thereof. The interventional medical device comprises: a stent body (1); a surface of the stent body (1) being provided with a drug releasing structure (3), and drug in the drug releasing structure (3) being drug for suppressing proliferation of adventitial fibroblasts and a drug for suppressing proliferation of intimal and/or smooth muscle cells. In use, after interventional medical device is implanted into a human body, the drug for suppressing proliferation of adventitial fibroblasts carried thereon can promote the compensatory expansion of the vessel, and the drug for suppressing proliferation of intimal cells and/or smooth muscle cells carried thereon can suppress intimal proliferation of the vessel. The combination of the two kinds of drugs greatly reduces the occurrence rate of in-stent restenosis.

摘要翻译： 介入医疗装置及其制造方法。 介入医疗装置包括：支架主体（1）; 支架体（1）的表面设有药物释放结构（3），药物释放结构（3）中的药物是抑制外膜成纤维细胞增殖的药物和抑制内膜和/或平滑增生的药物 肌肉细胞。 在使用中，将介入医疗装置植入人体后，用于抑制携带的外膜成纤维细胞增殖的药物可以促进血管的代偿性扩张，并且抑制其上承载的内膜细胞和/或平滑肌细胞增殖的药物 可以抑制血管的内膜增殖。 两种药物的组合大大降低了支架内再狭窄的发生率。

公开(公告)号：US20130296806A1

公开(公告)日：2013-11-07

申请号：US13703855

申请日：2011-06-13

申请人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

发明人： Junfei Li ,  Xi Hu ,  Chengyun Yue ,  Dawei Wang ,  Peng Huang ,  Zhirong Tang ,  Qiyi Luo ,  Zhaohua Chang

IPC分类号： A61L27/34

CPC分类号： A61L27/34 ,  A61L27/54 ,  A61L31/10 ,  A61L31/16 ,  A61L2300/42

摘要： The present invention discloses an interventional medical device and methods of making the same. At least one coating layer is disposed on the outer surface of the interventional medical device and the material of the outmost layer of the coating layer is a sulfonate group-containing polymer. In the present invention, the material of the outmost layer of the interventional medical device is a sulfonate group-containing polymer. The polymer is endowed with a same surface property as that of heparin in addition to appropriate hydrophilicity due to the presence of the sulfonate group. After the interventional medical device is implanted into the human body, a hydrophilic surface is formed on the outer surface of the interventional medical device which is also negatively charged in the body fluid. Therefore, cells can easily adhere and grow on the outer surface thereof as a result of the enhanced cell compatibility. Furthermore, due to a surface property that is the same as that of heparin, the material is provided with excellent anticoagulant properties which inhibit the thrombosis and lower down the incidence rate of post-operational complications.

摘要翻译： 本发明公开了一种介入医疗装置及其制造方法。 至少一个涂层设置在介入医疗装置的外表面上，涂层的最外层的材料是含磺酸基的聚合物。 在本发明中，介入医疗装置的最外层的材料是含磺酸基的聚合物。 由于存在磺酸盐基，除了适当的亲水性之外，聚合物具有与肝素相同的表面性质。 在将介入医疗装置植入人体后，在介入医疗装置的外表面上形成亲水性表面，其也在体液中带负电。 因此，由于细胞相容性的增强，细胞可以容易地附着和生长在其外表面上。 此外，由于与肝素相同的表面特性，具有优异的抗凝血性，能够抑制血栓形成，降低手术后并发症的发生率。

公开(公告)号：US06492232B1

公开(公告)日：2002-12-10

申请号：US09563796

申请日：2000-05-02

申请人： Zhirong Tang ,  Heemyong Park ,  Jenny M. Ford

发明人： Zhirong Tang ,  Heemyong Park ,  Jenny M. Ford

IPC分类号： H01L21336

CPC分类号： H01L29/66666 ,  H01L21/823885 ,  H01L29/1045 ,  H01L29/7827

摘要： An n-channel device (10) and a p-channel device (11) are formed from a single epitaxial silicon layer (60,61). During the deposition of the single epitaxial silicon layer (60,61), dopants are added to the epitaxial reaction chamber and subsequently changed to define a drain region (24,33), a channel region (27,34), and a source region (30,35). The dopant concentration is modified during the formation of the channel region (27,34) to create a doping profile (50). The doping profile (50) has a first profile (51) that is constant and a second profile (52) that changes.

摘要翻译： 由单个外延硅层（60,61）形成n沟道器件（10）和p沟道器件（11）。 在沉积单个外延硅层（60,61）期间，将掺杂物添加到外延反应室中，随后改变为限定漏极区（24,33），沟道区（27,34）和源极区 （30,35）。 掺杂剂浓度在沟道区（27,34）的形成过程中被修改以产生掺杂分布（50）。 掺杂分布（50）具有恒定的第一分布（51）和改变的第二分布（52）。