公开(公告)号：US20170247451A1

公开(公告)日：2017-08-31

申请号：US15592115

申请日：2017-05-10

Applicant: AMGEN INC.

Inventor： Cen XU ,  Agnes Eva HAMBURGER

IPC: A61K47/48 ,  C07K16/28 ,  C07K19/00 ,  A61K39/395

CPC classification number: C07K16/28 ,  C07K16/2869 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies and antigen-binding fragments thereof that bind to human PAC1 are provided. Nucleic acids encoding the antibodies and antigen-binding fragments thereof, vectors, and cells encoding the same are also provided. The antibodies and antigen-binding fragments thereof can inhibit binding of PAC1 to PACAP, and are useful in a number of PAC1 related disorders, including the treatment and/or prevention of headache disorders, including migraine and cluster headache.