摘要:
Disclosed are 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, their stereoisomers, tautomers, pharmaceutically acceptable salts, and prodrugs thereof; compositions that include a pharmaceutically acceptable carrier and one or more of the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent. Disclosed also are methods of using the 2-amino-7,8-dihydro-6H-pyrido[4,3-d]pyrimidin-5-one compounds, either alone or in combination with at least one additional therapeutic agent, in the prophylaxis or treatment of cellular proliferative, viral, autoimmune, cardiovascular, and central nervous system diseases.
摘要:
New substituted benz-azole compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.
摘要:
Multilayered canted coil springs and methods that improve mechanical, electrical and thermal properties of canted coil springs. In some embodiments, properties of dissimilar materials are combined into the spring using various material layers. For example, in one embodiment a protective or high strength outer layer material shields a more sensitive inner core material from harsh environments and conditions. The inner core material may be a highly electrically conductive material, with the outer layer material having an electrical conductivity lower than the core. In various embodiments the following characteristics of the spring are improved: electrical and/or thermal conductivity, corrosion resistance, biocompatibility, temperature resistance, stress relaxation, variable frictional force, and wear resistance in harsh environments and conditions.
摘要:
A connector assembly is provided for connecting, two planar surfaces or structures together to permit electrical transmission between the two. As described, the connector have at least two housing sections having grooves formed therein for receiving springs, such as canted coil springs. The springs are configured to provide constant mechanical and electrical connection between multiple parts and allow for small motions between such parts. By allowing for movement of the connected parts, adequate connection during thermal changes and/or vibrations is maintained. This is possible due to the spring contact interface between the connector assembly and the connecting parts, which allows relative movement between the springs and the connecting parts.
摘要:
The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention further provides pharmaceutical compositions comprising these compounds, and combinations comprising these compounds combined with or used with a therapeutic co-agent, as well as therapeutic uses of these compounds and compositions. These are useful in the treatment of diseases such as cancer that are associated with activation of ERK1 and/or ERK2, and especially for MAPK pathway dependent cancers showing resistance to Raf and/or MEK inhibitory cancer therapeutics.
摘要:
The present invention provides compounds of Formula (I) and pharmaceutically acceptable salts thereof; as further described herein. The present invention further provides pharmaceutical compositions comprising these compounds, and combinations comprising these compounds combined with or used with a therapeutic co-agent, as well as therapeutic uses of these compounds and compositions. These are useful in the treatment of diseases such as cancer that are associated with activation of ERK1 and/or ERK2, and especially for MAPK pathway dependent cancers showing resistance to Raf and/or MEK inhibitory cancer therapeutics