公开(公告)号：US20130245235A1

公开(公告)日：2013-09-19

申请号：US13860016

申请日：2013-04-10

Applicant: AMGEN, INC.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Wenyan Shen ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo

IPC: C07K16/40

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.

公开(公告)号：US20130052201A1

公开(公告)日：2013-02-28

申请号：US13656392

申请日：2012-10-19

Applicant: Amgen, Inc.

Inventor： Simon Mark Jackson ,  Nigel Pelham Clinton Walker ,  Derek Evan Piper ,  Bei Shan ,  Wayne Shen ,  Joyce Chi Yee Chan ,  Chadwick Terence King ,  Randal Robert Ketchem ,  Christopher Mehlin ,  Teresa Arazas Carabeo ,  Qiong Cao

IPC: A61K39/395 ,  A61P3/06

CPC classification number: C07K16/40 ,  A61K31/22 ,  A61K31/366 ,  A61K31/40 ,  A61K31/405 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505 ,  A61K31/66 ,  A61K39/395 ,  A61K39/3955 ,  A61K45/06 ,  A61K2039/505 ,  C07K2299/00 ,  C07K2317/14 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92 ,  C12N15/1137 ,  A61K2300/00

Abstract: Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.