-
公开(公告)号:US07998977B2
公开(公告)日:2011-08-16
申请号:US12300358
申请日:2007-06-12
申请人: Sajan Joseph , Renhua Li , Michael Ray Myers , Aktham Aburub , Jenny Pingqi Dai , Christopher Randall Schmid
发明人: Sajan Joseph , Renhua Li , Michael Ray Myers , Aktham Aburub , Jenny Pingqi Dai , Christopher Randall Schmid
IPC分类号: A01N43/42 , A61K31/47 , C07D217/00
CPC分类号: C07D217/02
摘要: 4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds and methods of using these compounds.
摘要翻译: 4- [5-(2-氨基 - 乙磺酰基) - 异喹啉-7-基] - 苯酚或其药学上可接受的盐或化合物或其盐的水合物作为抗肿瘤和/或抗病毒剂的Akt抑制剂 作为包含这些化合物的组合物和使用这些化合物的方法。
-
公开(公告)号:US20100120801A1
公开(公告)日:2010-05-13
申请号:US12611139
申请日:2009-11-03
IPC分类号: A61K31/519 , C07D487/04
CPC分类号: C07D487/04 , C07D473/34
摘要: The present invention provides AKT and p70 S6 kinase inhibitors of the formula: The present invention also provides pharmaceutical compositions comprising compounds of Formula I, uses of compounds of Formula I and methods of using compounds of Formula I.
摘要翻译: 本发明提供下式的AKT和p70 S6激酶抑制剂:本发明还提供包含式I化合物的药物组合物,式I化合物的用途和使用式I化合物的方法。
-
公开(公告)号:US20090163714A1
公开(公告)日:2009-06-25
申请号:US12396103
申请日:2009-03-02
IPC分类号: C07D487/04
CPC分类号: C07D487/04
摘要: The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use.
摘要翻译: 本发明提供下式的p70 S6激酶抑制剂:包含它们的药物制剂及其使用方法。
-
24.7-phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (protein kinase B) 失效
标题翻译: 作为akt(蛋白激酶B)的抑制剂的7-苯基 - 异喹啉-5-磺酰基氨基衍生物公开(公告)号:US07449477B2
公开(公告)日:2008-11-11
申请号:US10595798
申请日:2004-11-22
申请人: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
发明人: David Anthony Barda , Kenneth James Henry, Jr. , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Enrico Richett
IPC分类号: C07D217/22 , C07D401/12 , A61K31/4725 , A61K31/472
CPC分类号: C04B35/632 , C07D217/02 , C07D217/22 , C07D401/12
摘要: The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及作为AKT活性抑制剂的式(I)化合物,其可用于治疗易感性肿瘤和病毒感染。
-
公开(公告)号:US20130190262A1
公开(公告)日:2013-07-25
申请号:US13877923
申请日:2011-11-01
申请人: Sajan Joseph , Susanta Samajdar
发明人: Sajan Joseph , Susanta Samajdar
IPC分类号: C07D401/14 , C07C53/10 , A61K31/7068 , C07C55/10 , A61K31/497 , A61K31/704 , C07C309/04 , C07C55/07
CPC分类号: C07D401/14 , A61K31/497 , A61K31/704 , A61K31/7068 , C07C53/10 , C07C55/07 , C07C55/10 , C07C309/04
摘要: The present invention provides an aminopyrazole compound, or a pharmaceutically acceptable salt thereof, that inhibits Chk1 and is useful in the treatment of cancer.
摘要翻译: 本发明提供抑制Chk1并可用于治疗癌症的氨基吡唑化合物或其药学上可接受的盐。
-
公开(公告)号:US08093383B2
公开(公告)日:2012-01-10
申请号:US12396103
申请日:2009-03-02
申请人: Sajan Joseph
发明人: Sajan Joseph
IPC分类号: C07D487/00
CPC分类号: C07D487/04
摘要: The present invention provides p70 S6 kinase inhibitors of the formula: pharmaceutical formulations comprising them, and methods for their use.
摘要翻译: 本发明提供下式的p70 S6激酶抑制剂:包含它们的药物制剂及其使用方法。
-
公开(公告)号:US20090221633A1
公开(公告)日:2009-09-03
申请号:US12300358
申请日:2007-06-12
申请人: Sajan Joseph , Renhua Li , Michael Ray Myers , Aktham Aburub , Jenny Pingqi Dai , Christopher Randall Schmid
发明人: Sajan Joseph , Renhua Li , Michael Ray Myers , Aktham Aburub , Jenny Pingqi Dai , Christopher Randall Schmid
IPC分类号: A61K31/472 , C07D217/00 , A61P35/00
CPC分类号: C07D217/02
摘要: 4-[5-(2-Amino-ethanesulfonyl)-isoquinolin-7-yl]-phenol or a pharmaceutically acceptable salt thereof or a hydrate of the compound or the salt thereof as Akt inhibitors that are antineoplastic and/or antiviral agents as well as compositions comprising these compounds and methods of using these compounds.
摘要翻译: 4- [5-(2-氨基 - 乙磺酰基) - 异喹啉-7-基] - 苯酚或其药学上可接受的盐或化合物或其盐的水合物作为抗肿瘤和/或抗病毒剂的Akt抑制剂 作为包含这些化合物的组合物和使用这些化合物的方法。
-
公开(公告)号:US20070043040A1
公开(公告)日:2007-02-22
申请号:US10547969
申请日:2004-03-25
申请人: Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
发明人: Rima Al-Awar , David Barda , Albert Dee , Kenneth Henry Jr , Sajan Joseph , Ho-Shen Lin , Jose Lopez , Michael Richett , Carmen Somoza
IPC分类号: A61K31/5377 , A61K31/4709 , C07D413/02 , C07D401/02
CPC分类号: C07D401/02 , C07D217/04 , C07D217/22 , C07D217/24 , C07D405/12 , C07D409/12 , C07D413/02 , C07D413/12
摘要: The present invention relates to compounds Formula (I): as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及式(I)化合物:作为AKT活性抑制剂,其可用于治疗易感性肿瘤和病毒感染。
-
29.7-Phenyl-isoquinoline-5-sulfonylamino derivatives as inhibitors of akt (proteinkinase b) 失效
标题翻译: 作为akt抑制剂的7-苯基 - 异喹啉-5-磺酰氨基衍生物(蛋氨酸酶b)公开(公告)号:US20070037796A1
公开(公告)日:2007-02-15
申请号:US10595798
申请日:2004-11-22
申请人: David Barda , Kenneth Henry , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Richett
发明人: David Barda , Kenneth Henry , Jianping Huang , Sajan Joseph , Ho-Shen Lin , Michael Richett
IPC分类号: A61K31/551 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/4709 , C07D217/22 , C07D417/02 , C07D413/02 , C07D403/02
CPC分类号: C04B35/632 , C07D217/02 , C07D217/22 , C07D401/12
摘要: The present invention relates to compounds Formula (I) as inhibitors of AKT activity, which are useful for the treatment of susceptible neoplasms and viral infections.
摘要翻译: 本发明涉及作为AKT活性抑制剂的式(I)化合物,其可用于治疗易感性肿瘤和病毒感染。
-
公开(公告)号:US06743785B2
公开(公告)日:2004-06-01
申请号:US10130801
申请日:2002-05-21
申请人: Rima Salim Al-Awar , Kyle Andrew Hecker , Jianping Huang , Sajan Joseph , James Edward Ray , Philip Parker Waid
发明人: Rima Salim Al-Awar , Kyle Andrew Hecker , Jianping Huang , Sajan Joseph , James Edward Ray , Philip Parker Waid
IPC分类号: C07D40314
CPC分类号: C07D487/22 , C07F7/1804
摘要: The present invention provides selective kinase inhibitors of formula (I).
摘要翻译: 本发明提供式(I)的选择性激酶抑制剂。
-
-
-
-
-
-
-
-
-