公开(公告)号：US07834248B2

公开(公告)日：2010-11-16

申请号：US11699817

申请日：2007-01-30

申请人： Allan Green ,  Surinder Singh ,  Marit Lenman ,  Sten Stymne

发明人： Allan Green ,  Surinder Singh ,  Marit Lenman ,  Sten Stymne

IPC分类号： A01H5/00

CPC分类号： C12N9/0071 ,  C12N9/0004 ,  C12N15/8247 ,  C12P7/6409 ,  C12P7/6427 ,  C12P7/6472

摘要： The present invention relates generally to novel genetic sequences that encode fatty acid epoxygenase enzymes, in particular fatty acid Δ12-epoxygenase enzymes from plants that are mixed function monooxygenase enzymes. More particularly, the present invention exemplifies cDNA sequences from Crepis spp. and Vernonia galamensis that encode fatty acid Δ12-epoxygenases. The genetic sequences of the present invention provide the means by which fatty acid metabolism may be altered or manipulated in organisms, such as, for example, yeasts, moulds, bacteria, insects, birds, mammals and plants, and more particularly in plants. The invention also extends to genetically modified oil-accumulating organisms transformed with the subject genetic sequences and to the oils derived therefrom. The oils thus produced provide the means for the cost-effective raw materials for use in the efficient production of coatings, resins, glues, plastics, surfactants and lubricants.

摘要翻译： 本发明一般涉及从作为混合功能单加氧酶的植物编码脂肪酸环氧化酶，特别是脂肪酸和Dgr 12-环氧化酶的新型遗传序列。 更具体地，本发明举例说明了来自Crepis spp的cDNA序列。 和Vernonia galamensis编码脂肪酸和Dgr; 12-环氧化酶。 本发明的遗传序列提供了在生物体例如酵母，霉菌，细菌，昆虫，鸟类，哺乳动物和植物中，更具体地在植物中可以改变或操纵脂肪酸代谢的方法。 本发明还延伸到用受试者遗传序列转化的转基因油积聚生物和由其衍生的油。 因此生产的油为用于有效生产涂料，树脂，胶水，塑料，表面活性剂和润滑剂的成本效益好的原材料提供了手段。

公开(公告)号：US20060063332A1

公开(公告)日：2006-03-23

申请号：US10949994

申请日：2004-09-23

申请人： Brian Doyle ,  Surinder Singh ,  Uday Shah ,  Justin Brask ,  Robert Chau

发明人： Brian Doyle ,  Surinder Singh ,  Uday Shah ,  Justin Brask ,  Robert Chau

IPC分类号： H01L21/336

CPC分类号： H01L29/7853 ,  H01L29/66795

摘要： A process is described for manufacturing of non-planar multi-corner transistor structures. A fin of a semiconductor material having a mask on a top surface of the fin is formed on a first insulating layer. A second insulating layer is formed on the fin exposing a top surface of the mask, wherein a protection layer is deposited between the fin and the second insulating layer. Next, the mask is removed and spacers are formed on the fin adjacent to the protection layer. A recess having a bottom and opposing sidewalls is formed in the fin. A gate dielectric layer and a gate electrode are formed on the top surface, the opposing sidewalls of the fin and on the bottom and on the opposing sidewalls of the recess in the fin. A source region and a drain region are formed in the fin at the opposite sides of the gate electrode.

摘要翻译： 描述了用于制造非平面多角晶体管结构的工艺。 在第一绝缘层上形成具有在鳍的顶表面上的掩模的半导体材料的鳍。 在翅片上形成第二绝缘层，露出掩模的顶表面，其中保护层沉积在散热片和第二绝缘层之间。 接下来，去除掩模，并且在与保护层相邻的翅片上形成间隔物。 在翅片中形成具有底部和相对侧壁的凹部。 栅极电介质层和栅电极形成在翅片的顶表面，翅片的相对侧壁和底部上以及凹槽的相对侧壁上。 源极区域和漏极区域形成在栅极的相对侧的鳍片中。

公开(公告)号：US20050273885A1

公开(公告)日：2005-12-08

申请号：US11112882

申请日：2005-04-22

申请人： Surinder Singh ,  Stanley Robert ,  Peter Nichols ,  Susan Ellis Blackburn ,  Xue-Rong Zhou ,  James Petrie ,  Allan Green

发明人： Surinder Singh ,  Stanley Robert ,  Peter Nichols ,  Susan Ellis Blackburn ,  Xue-Rong Zhou ,  James Petrie ,  Allan Green

IPC分类号： A01H1/00 ,  C12N5/04 ,  C12N9/02 ,  C12N9/10 ,  C12N15/82 ,  C12P7/64

CPC分类号： C12P7/6427 ,  C07C51/42 ,  C11B1/025 ,  C11B1/06 ,  C11B3/006 ,  C12N9/0083 ,  C12N9/1029 ,  C12N15/8247 ,  C12P7/6472 ,  Y02P20/52

摘要： The present invention relates to methods of synthesizing long-chain polyunsaturated fatty acids, especially eicosapentaenoic acid, docosapentaenoic acid and docosahexaenoic acid, in recombinant cells such as yeast or plant cells. Also provided are recombinant cells or plants which produce long-chain polyunsaturated fatty acids. Furthermore, the present invention relates to a group of new enzymes which possess desaturase or elongase activity that can be used in methods of synthesizing long-chain poly unsaturated fatty acids.

摘要翻译： 本发明涉及在重组细胞如酵母或植物细胞中合成长链多不饱和脂肪酸，特别是二十碳五烯酸，二十二碳五烯酸和二十二碳六烯酸的方法。 还提供了产生长链多不饱和脂肪酸的重组细胞或植物。 此外，本发明涉及可用于合成长链多不饱和脂肪酸的方法的一组具有去饱和酶或延伸酶活性的新酶。

公开(公告)号：US6004966A

公开(公告)日：1999-12-21

申请号：US871883

申请日：1997-06-09

申请人： Surinder Singh ,  Anthony Edward Lewis

发明人： Surinder Singh ,  Anthony Edward Lewis

IPC分类号： A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  A61P9/08 ,  A61P9/10 ,  C07D471/04 ,  C07D473/04 ,  C07D473/30 ,  C07D475/02 ,  C07D487/04 ,  A01N43/54 ,  A01N43/90 ,  C07D473/00 ,  C07D475/00

CPC分类号： C07D471/04 ,  A61K31/505 ,  A61K31/52 ,  A61K31/522 ,  C07D473/04 ,  C07D473/30 ,  C07D475/02 ,  C07D487/04

摘要： The use of a compound of formula I ##STR1## in which R.sub.1 and R.sub.2 are N, X.sub.1 and X.sub.2 which may be the same or different are hydrogen, hydroxy, or an optionally substituted alkyl, and Z.sub.1 and Z.sub.2 which may be the same or different are hydrogen, hydroxy, keto (.dbd.O), or one of Z.sub.1 and X.sub.1 and Z.sub.2 and X.sub.2 form a second bond of a double bond at the 1,6 or 2,3 positions with the proviso that at least one of the groupings R.sub.1 Z.sub.1 X.sub.1 R.sub.2 Z.sub.2 X.sub.2 and R.sub.1 X.sub.1 Z.sub.2 form a hydroxamate moiety (--N(OH)C(.dbd.O)-- in which R.sub.1 and R.sub.2 is N, Z.sub.1 and/or Z.sub.2 is .dbd.O and X.sub.1 and/or X.sub.2 is OH or R.sub.1 is N, Z.sub.2 is .dbd.O and X.sub.1 is OH and B is a 5 or 6 membered ring of formula II or III ##STR2## in which R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, R.sub.9, and R.sub.10 which may be the same or different are CH or N with the proviso that ring B cannot contain more than 3 ring members which are nitrogen and the ring B may optionally be substituted with a physiologically acceptable organic or inorganic acid, for the manufacture of a medicament for use as an anti-ischaemic agent.

摘要翻译： 使用其中R 1和R 2可以相同或不同的N，X 1和X 2的式I化合物是氢，羟基或任选取代的烷基，并且可以相同或不同的Z 1和Z 2是氢 ，羟基，酮基（= O）或Z 1和X 1中的一个，Z 2和X 2在1,6或2,3位上形成双键的第二键，条件是R1Z1X1R2Z2X2和R1X1Z2中的至少一个 形成氧肟基部分（-N（OH）C（= O） - ，其中R 1和R 2为N，Z 1和/或Z 2为= O且X 1和/或X 2为OH或R 1为N，Z 2为= O， X 1是OH，B是式II或III的5或6元环，其中可以相同或不同的R 4，R 5，R 6，R 7，R 8，R 9和R 10是CH或N，条件是环B 不能含有多于3个氮环的环成员，并且环B可以任选被生理上可接受的有机或无机酸取代，用于制备用作抗缺血剂的药物。

公开(公告)号：US5480894A

公开(公告)日：1996-01-02

申请号：US204202

申请日：1994-03-07

申请人： Robert C. Hider ,  Surinder Singh ,  Gary S. Tilbrook ,  Paul S. Dobbin

发明人： Robert C. Hider ,  Surinder Singh ,  Gary S. Tilbrook ,  Paul S. Dobbin

IPC分类号： C07D213/65 ,  A61K31/44 ,  A61K31/4418 ,  A61K31/4425 ,  A61P39/02 ,  C07D213/69 ,  C09K3/00 ,  C07D211/74

CPC分类号： C07D213/69

摘要： 3-Hydroxypyridin-4-ones of formula (I) ##STR1## in which R.sub.1 is a methyl, ethyl, 2-(.alpha.-methylpropionyloxy)ethyl or 2-pivoloyloxyethyl group and R.sub.2, R.sub.3 and R.sub.4 are each separately selected from hydrogen and methyl, ethyl, 2-(.alpha.-methylpropionyloxy)ethyl and 2-pivaloyloxyethyl groups with the provisos that (a) one only of R.sub.1 to R.sub.4 is either a 2-(.alpha.-methylpropionyloxy)ethyl group or a 2-pivaloyloxyethyl group, (b) at least one of R.sub.2 and R.sub.3 is other than hydrogen and (c) the total number of carbon atoms in R.sub.1 to R.sub.4 is no more than eleven, and physiologically acceptable salts thereof are of use in therapy, particularly in the treatment of conditions in which there is a toxic concentration of a metal, for example iron, in the body.

摘要翻译： PCT No.PCT / GB93 / 01007 Sec。 371日期：1994年3月7日 102（e）1994年3月7日PCT PCT 1993年5月18日PCT公布。 出版物WO94 / 04498 日期：1993年3月3日。式（I）的3-羟基吡啶-4-酮其中R 1是甲基，乙基，2-（α-甲基丙酰氧基）乙基或2-桥联合氧基乙基，R2，R3和 R 4各自独立地选自氢和甲基，乙基，2-（α-甲基丙酰氧基）乙基和2-新戊酰氧基乙基，条件是（a）仅一个R 1至R 4是2-（α-甲基丙酰氧基）乙基 或2-新戊酰氧基乙基，（b）R 2和R 3中的至少一个不同于氢，（c）R 1至R 4中的总碳原子数不超过11​​，其生理上可接受的盐可用于 特别是在治疗身体中存在金属（例如铁）的毒性浓度的条件下。