公开(公告)号：US20200055936A1

公开(公告)日：2020-02-20

申请号：US16493712

申请日：2018-03-13

Applicant: Five Prime Therapeutics, Inc. ,  Bristol-Myers Squibb Company

Inventor： Robert J. Johnston ,  Arvind Rajpal ,  Paul O. Sheppard ,  Luis Borges ,  Andrew Rankin ,  Keith Sadoon Bahjat ,  Alan J. Korman ,  Andy X. Deng ,  Lin Hui Su ,  Ginger Rakestraw

IPC: C07K16/28

Abstract: The present application relates to antibodies specifically binding to the V-domain immunoglobulin-containing suppressor of T-cell activation (VISTA) at acidic pH and their use in cancer treatment. In some embodiments, the antibodies bind specifically to human VISTA at acidic pH, but do not significantly bind to human VISTA at neutral or physiological pH.

公开(公告)号：US20180057600A1

公开(公告)日：2018-03-01

申请号：US15807351

申请日：2017-11-08

Applicant: Pflzer Inc. ,  Bristol-Myers Squibb Company

Inventor： Jing MIN ,  Yanli Wu ,  Rory F. Finn ,  Barrett R. Thiele ,  Wei Liao ,  Ronald P. Gladue ,  Arvind Rajpal ,  Timothy J. Paradis ,  Peter Brams ,  Brigitte Devaux ,  Yi Wu ,  Kristopher Toy ,  Heidi N. Leblanc ,  Haichun Huang

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

公开(公告)号：US20150218279A1

公开(公告)日：2015-08-06

申请号：US14692948

申请日：2015-04-22

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： Jing Min ,  Yanli Wu ,  Rory F. Finn ,  Barrett R. Thiele ,  Wei Liao ,  Ronald P. Gladue ,  Arvind Rajpal ,  Timothy J. Paradis ,  Peter Brams ,  Brigitte Devaux ,  Yi Wu ,  Kristopher Toy ,  Heidi N. LeBlanc ,  Haichun Huang

IPC: C07K16/28

CPC classification number: C07K16/2878 ,  A61K2039/505 ,  C07K2317/14 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/92

Abstract: The present disclosure provides isolated binding molecules that bind to the human OX40R, nucleic acid molecules encoding an amino acid sequence of the binding molecules, vectors comprising the nucleic acid molecules, host cells containing the vectors, methods of making the binding molecules, pharmaceutical compositions containing the binding molecules, and methods of using the binding molecules or compositions.

Abstract translation: 本公开提供了结合人OX40R的分离的结合分子，编码结合分子的氨基酸序列的核酸分子，包含核酸分子的载体，含有载体的宿主细胞，制备结合分子的方法，含有 结合分子，以及使用结合分子或组合物的方法。

公开(公告)号：US08846037B2

公开(公告)日：2014-09-30

申请号：US13857867

申请日：2013-04-05

Applicant: Pfizer Inc. ,  Bristol-Myers Squibb Company

Inventor： Arvind Rajpal ,  Madhav Narasimha Devalaraja ,  Kristopher Toy ,  Lan Yang ,  Haichun Huang ,  Jun Zhang ,  Peter Brams ,  Brigitte Devaux ,  David B. Passmore

IPC: A61K39/395 ,  A61K39/00 ,  C07K16/24

CPC classification number: C07K16/248 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/92

Abstract: Antibodies and antigen-binding portions thereof that bind to human IL-6 are provided. Also provided are nucleic acids encoding such antibodies and antigen binding portions, methods of making such antibodies and antigen binding portions, compositions comprising such antibodies or antigen binding portions, and uses of such antibodies or antigen binding portions.

Abstract translation: 提供了结合人IL-6的抗体及其抗原结合部分。 还提供了编码此类抗体和抗原结合部分的核酸，制备此类抗体和抗原结合部分的方法，包含此类抗体或抗原结合部分的组合物，以及此类抗体或抗原结合部分的用途。