公开(公告)号：US08639332B2

公开(公告)日：2014-01-28

申请号：US12845830

申请日：2010-07-29

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

IPC分类号： A61N1/365

CPC分类号： A61B5/14551 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/3925 ,  A61N1/3956

摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.

摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器 模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能 趋势。

公开(公告)号：US08352008B2

公开(公告)日：2013-01-08

申请号：US12797831

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis

IPC分类号： A61B5/00

CPC分类号： A61B5/1459 ,  A61B5/1495

摘要： A medical device system and associated method are used for monitoring tissue oxygenation. An optical sensor produces a signal corresponding to tissue light attenuation. A processor receives the optical sensor signal and computes a first measure of light attenuation at a first light wavelength and a second measure of light attenuation at a second light wavelength. In one embodiment, noise cancellation circuitry receives the first measure and the second measure and generates a guessed ratio of the first and second measures. Using the first measure, the second measure and the guessed ratio, the noise cancellation circuitry provides a peak output power when the guessed ratio corresponds to an actual ratio of the first and second measures.

摘要翻译： 医疗器械系统和相关方法用于监测组织氧合。 光学传感器产生对应于组织光衰减的信号。 处理器接收光学传感器信号并且计算第一光波长处的光衰减的第一测量值和在第二光波长处的光衰减的第二测量值。 在一个实施例中，噪声消除电路接收第一测量和第二测量并产生第一和第二测量的猜测比率。 使用第一测量，第二测量和猜测比率，当猜测比率对应于第一和第二测量的实际比率时，噪声消除电路提供峰值输出功率。

公开(公告)号：US20110066198A1

公开(公告)日：2011-03-17

申请号：US12845830

申请日：2010-07-29

申请人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

发明人： Jonathan L. Kuhn ,  Can Cinbis ,  David A. Anderson ,  William J. Havel

IPC分类号： A61N1/36

CPC分类号： A61B5/14551 ,  A61B5/1459 ,  A61B5/6846 ,  A61B5/7285 ,  A61N1/36557 ,  A61N1/3925 ,  A61N1/3956

摘要： A method and device for delivering therapy that includes an electrode to sense cardiac signals and to deliver a therapy, a therapy delivery module coupled to the electrode to deliver a therapy via the electrode in response to the sensed cardiac signals, a sensor emitting light and detecting emitted light scattered by a tissue volume adjacent the optical sensor to generate a corresponding detected light intensity output signal, a control module coupled to the sensor to control light emission of the sensor in response to delivering the therapy, and a controller coupled to the therapy delivery module and the sensor, the controller configured to determine tissue oxygenation measurements in response to the output signal, determine a tissue oxygenation trend in response to the tissue oxygenation measurements, and determine whether the delivered therapy restored cardiac hemodynamic function in response to the determined tissue oxygenation trend.

摘要翻译： 一种用于递送治疗的方法和装置，其包括用于感测心脏信号并递送治疗的电极，治疗递送模块，其耦合到所述电极，以响应于感测到的心脏信号经由所述电极递送治疗;发射光和检测的传感器 发射由邻近光学传感器的组织体积散射的光，以产生对应的检测到的光强度输出信号;耦合到传感器的控制模块，以响应于递送治疗来控制传感器的光发射;以及耦合到治疗传递的控制器 模块和传感器，所述控制器被配置为响应于所述输出信号确定组织氧合测量，响应于所述组织氧合测量确定组织氧合趋势，并且确定所递送的治疗是否响应于所确定的组织氧合来恢复心脏血液动力学功能 趋势。

公开(公告)号：US20100317940A1

公开(公告)日：2010-12-16

申请号：US12797800

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。

公开(公告)号：US08463346B2

公开(公告)日：2013-06-11

申请号：US12797800

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/00

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a sensor capable of being advanced transvascularly to be positioned along a volume of tissue, the sensor including a first combination of a light source and a light detector to emit light into a volume of tissue and to detect light scattered by the volume of tissue and to generate a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal and compute a measure of tissue oxygenation using the light detector output signal.

摘要翻译： 用于监测患者状况的医疗装置包括能够经血管内先进地沿着组织体积定位的传感器，所述传感器包括光源和光检测器的第一组合，以将光发射到一定体积的组织中并且检测 通过组织体积散射的光并产生对应于检测到的光的强度的第一输出信号。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号并且使用 光检测器输出信号。

公开(公告)号：US08346332B2

公开(公告)日：2013-01-01

申请号：US12797811

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/00

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.

摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。

公开(公告)号：US20100317941A1

公开(公告)日：2010-12-16

申请号：US12797811

申请日：2010-06-10

申请人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

发明人： Jonathan L. Kuhn ,  David A. Anderson ,  Can Cinbis ,  Richard J. O'Brien ,  Yong K. Cho ,  Thomas J. Mullen ,  Avram Scheiner ,  Rodolphe P. Katra

IPC分类号： A61B5/1455

CPC分类号： A61N1/36557 ,  A61B5/1459 ,  A61N1/37258

摘要： A medical device for monitoring a patient condition includes a first combination of a light source and a light detector to emit light into a volume of tissue, detect light scattered by the volume of tissue, and provide a first output signal corresponding to an intensity of the detected light. A control module is coupled to the light source to control the light source to emit light at least four spaced-apart light wavelengths, and a monitoring module is coupled to the light detector to receive the output signal, compute a measure of tissue oxygenation in response to the light detector output signal, and detect tissue hypoxia using the measure of tissue oxygenation.

摘要翻译： 用于监测患者状况的医疗装置包括光源和光检测器的第一组合，以将光发射到组织的体积中，检测由组织体积散射的光，并提供对应于组织的强度的第一输出信号 检测到光。 控制模块耦合到光源以控制光源发射至少四个间隔开的光波长的光，并且监测模块耦合到光检测器以接收输出信号，计算响应中组织氧合的量度 到光检测器输出信号，并使用组织氧合的测量来检测组织缺氧。

公开(公告)号：US20120109258A1

公开(公告)日：2012-05-03

申请号：US12915788

申请日：2010-10-29

申请人： Can Cinbis ,  David A. Anderson ,  Michael A. Reinert ,  Xiaonan Shen ,  James K. Carney ,  Michael B. Terry

发明人： Can Cinbis ,  David A. Anderson ,  Michael A. Reinert ,  Xiaonan Shen ,  James K. Carney ,  Michael B. Terry

IPC分类号： A61N1/08

CPC分类号： A61N1/37217 ,  A61B5/0028 ,  A61N1/08 ,  H04B13/005

摘要： Aspects of the present disclosure include a medical device system including an implantable medical device and an external device with three or more electrodes configured to contact a patient's skin. The external device either transmits or receives a test signal to or from the implantable medical device using a plurality of possible receive dipoles, where each possible receive dipole is formed by a pair of electrodes. A signal quality monitor, either at the implantable medical device or at the external device, measures a signal quality for the possible receive dipoles.

摘要翻译： 本公开的方面包括包括可植入医疗装置的医疗装置系统和具有被配置为接触患者皮肤的三个或更多个电极的外部装置。 外部设备使用多个可能的接收偶极子向可植入医疗设备发送测试信号或从可植入医疗设备接收测试信号，其中每个可能的接收偶极由一对电极形成。 在可植入医疗设备或外部设备处的信号质量监视器测量可能的接收偶极子的信号质量。

公开(公告)号：US20090030334A1

公开(公告)日：2009-01-29

申请号：US11781734

申请日：2007-07-23

申请人： David A. Anderson ,  Can Cinbis

发明人： David A. Anderson ,  Can Cinbis

IPC分类号： A61B5/02

CPC分类号： A61N1/36514 ,  A61B7/003 ,  A61B7/006 ,  A61B7/008 ,  A61B2562/0204 ,  A61N1/36578 ,  A61N1/3702

摘要： An implantable medical device system senses a first signal using a first acoustical sensor adapted to be operatively positioned in a first internal body location for sensing heart sounds in a patient. The system includes a second acoustical sensor adapted to be operatively positioned in a second internal body location for sensing sounds in the patient and generate a second signal that is less responsive to the heart sounds than the first acoustical signal. An implantable medical device including a housing and a processor enclosed in the housing receives the first signal and the second signal and generates a corrected first signal by canceling non-cardiac signals in the first signal using the second signal.

摘要翻译： 植入式医疗设备系统使用适于被操作地定位在第一内部身体位置中的第一声学传感器来感测第一信号，以感测患者心脏的声音。 该系统包括适于可操作地定位在第二内部身体位置中的第二声学传感器，用于感测患者中的声音，并产生比第一声学信号对心音响应较小的第二信号。 包括壳体和封装在壳体中的处理器的可植入医疗装置接收第一信号和第二信号，并且通过使用第二信号消除第一信号中的非心脏信号来产生校正的第一信号。

公开(公告)号：US07682316B2

公开(公告)日：2010-03-23

申请号：US11781734

申请日：2007-07-23

申请人： David A. Anderson ,  Can Cinbis

发明人： David A. Anderson ,  Can Cinbis

IPC分类号： A61B5/02

CPC分类号： A61N1/36514 ,  A61B7/003 ,  A61B7/006 ,  A61B7/008 ,  A61B2562/0204 ,  A61N1/36578 ,  A61N1/3702

摘要： An implantable medical device system senses a first signal using a first acoustical sensor adapted to be operatively positioned in a first internal body location for sensing heart sounds in a patient. The system includes a second acoustical sensor adapted to be operatively positioned in a second internal body location for sensing sounds in the patient and generate a second signal that is less responsive to the heart sounds than the first acoustical signal. An implantable medical device including a housing and a processor enclosed in the housing receives the first signal and the second signal and generates a corrected first signal by canceling non-cardiac signals in the first signal using the second signal.

摘要翻译： 植入式医疗设备系统使用适于被操作地定位在第一内部身体位置中的第一声学传感器来感测第一信号，以感测患者心脏的声音。 该系统包括适于可操作地定位在第二内部身体位置中的第二声学传感器，用于感测患者中的声音，并产生比第一声学信号对心音响应较小的第二信号。 包括壳体和封装在壳体中的处理器的可植入医疗装置接收第一信号和第二信号，并且通过使用第二信号消除第一信号中的非心脏信号来产生校正的第一信号。