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公开(公告)号：US20120171668A1
公开(公告)日：2012-07-05
申请号：US13339066
申请日：2011-12-28
IPC分类号： C12Q1/68 , G01N33/536
CPC分类号： G01N33/5306 , G01N33/581
摘要： This disclosure relates to compositions that enhance the deposition of detectable moieties on tissue samples, methods utilizing these compositions and kits including these compositions. The compositions include a deposition enhancer having a formula where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other than sulfur, and any combination thereof; n is 1-5, an enzyme, a specific binding moiety and a detectable moiety.
摘要翻译： 本公开涉及增强组织样品上可检测部分沉积的组合物，利用这些组合物的方法和包括这些组合物的试剂盒。 组合物包括具有下式的沉积增强剂：其中R 1，R 2，R 3和R 4独立地选自脂族，芳基，卤素，含杂原子的部分和氢; R 1和/或R 3可以与R 2结合形成稠合的芳环体系; R5选自含杂原子的部分; A选自碳原子，除硫以外的杂原子及其任意组合; n为1-5，酶，特异性结合部分和可检测部分。
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公开(公告)号：US08871442B2
公开(公告)日：2014-10-28
申请号：US13339066
申请日：2011-12-28
CPC分类号： G01N33/5306 , G01N33/581
摘要： This disclosure relates to compositions that enhance the deposition of detectable moieties on tissue samples, methods utilizing these compositions and kits including these compositions. The compositions include a deposition enhancer having a formula where R1, R2, R3, and R4 are independently selected from aliphatic, aryl, halogen, a heteroatom-containing moiety, and hydrogen; R1 and/or R3 can be bound to R2 to form a fused, aromatic ring system; R5 is selected from a heteroatom-containing moiety; A is selected from, a carbon atom, a heteroatom, other than sulfur, and any combination thereof; n is 1-5, an enzyme, a specific binding moiety and a detectable moiety.
摘要翻译： 本公开涉及增强组织样品上可检测部分沉积的组合物，利用这些组合物的方法和包括这些组合物的试剂盒。 组合物包括具有下式的沉积增强剂：其中R 1，R 2，R 3和R 4独立地选自脂族，芳基，卤素，含杂原子的部分和氢; R 1和/或R 3可以与R 2结合形成稠合的芳环体系; R5选自含杂原子的部分; A选自碳原子，除硫以外的杂原子及其任意组合; n为1-5，酶，特异性结合部分和可检测部分。
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