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公开(公告)号：US08247401B2
公开(公告)日：2012-08-21
申请号：US12740105
申请日：2008-10-29
申请人： Christopher S. Burgey , Diem Nguyen , Zhengwu Deng , Daniel V. Paone , Craig M. Potteiger , Joseph P. Vacca
发明人： Christopher S. Burgey , Diem Nguyen , Zhengwu Deng , Daniel V. Paone , Craig M. Potteiger , Joseph P. Vacca
IPC分类号： A61K31/397 , A61K31/5377 , A61K31/538 , A61K31/506 , A61K31/425 , A61K31/44 , A61K31/4427 , A61K31/445 , A61K31/495 , A61K31/42 , A61K31/4245 , A61K31/4155 , A61K31/4192 , A61K31/4196 , C07D265/28 , C07D413/00 , C07D401/00 , C07D471/00 , C07D491/00
CPC分类号： C07C233/66 , C07C233/65 , C07C233/83 , C07C233/87 , C07D213/56 , C07D213/61 , C07D213/89 , C07D239/26 , C07D249/08 , C07D271/06 , C07D401/12 , C07D401/14 , C07D413/14
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译： 本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。
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公开(公告)号：US20120015052A1
公开(公告)日：2012-01-19
申请号：US13258943
申请日：2010-03-15
申请人： Christopher S. Burgey , Brendan M. Crowley , Zhengwu J. Deng , Daniel V. Paone , Craig M. Potteiger
发明人： Christopher S. Burgey , Brendan M. Crowley , Zhengwu J. Deng , Daniel V. Paone , Craig M. Potteiger
IPC分类号： A61K33/00 , C07D231/56 , C07D401/12 , A61P25/00 , A61K31/4162 , A61K31/4439 , A61K31/5377 , C07D487/04 , C07D413/12
CPC分类号： C07D401/12 , A61K31/16 , A61K31/405 , A61K31/415 , A61K45/06 , C07D413/12 , C07D413/14 , C07D495/04 , A61K2300/00
摘要： The subject invention relates to novel P2X3 receptor antagonists that play a critical role in treating disease states associated with pain, in particular peripheral pain, inflammatory pain, or tissue injury pain that can be treated using a P2X3 receptor subunit modulator.
摘要翻译： 本发明涉及在治疗与疼痛有关的疾病状态，特别是外周疼痛，炎症性疼痛或可用P2X3受体亚基调节剂治疗的组织损伤疼痛中发挥关键作用的新型P2X3受体拮抗剂。
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公开(公告)号：US07745427B2
公开(公告)日：2010-06-29
申请号：US11665943
申请日：2005-10-18
IPC分类号： C07D471/04 , C07D471/20 , A61K31/55 , A61P25/06
CPC分类号： C07D471/04
摘要： The present invention is directed to compounds of Formula (I) and Formula (II) (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式（I）和式（II）的化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y为 如本文所定义）可用作CGRP受体的拮抗剂并且可用于治疗或预防涉及CGRP的疾病，例如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07534784B2
公开(公告)日：2009-05-19
申请号：US12082233
申请日：2008-04-09
申请人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Zhengwu J. Deng , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
IPC分类号： C07D401/14 , A61K31/55 , A61P25/06
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及式I化合物（其中变量R1，R2，R3，R4，A，B，G，J，Q，T，U，V，W，X和Y如本文所定义） CGRP受体的拮抗剂，可用于治疗或预防涉及CGRP的疾病，如头痛，偏头痛和丛集性头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US07452903B2
公开(公告)日：2008-11-18
申请号：US11724066
申请日：2007-03-14
申请人： Christopher S. Burgey , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
发明人： Christopher S. Burgey , Diem N. Nguyen , Daniel V. Paone , Anthony W. Shaw , Theresa M. Williams
IPC分类号： C07D471/02 , C07D513/02 , A61K31/44 , A61P25/06
CPC分类号： C07D487/04 , C07D471/04
摘要： The present invention is directed to compounds of Formula I: and Formula II: (where variables R1, R2, R3, R4, A, B, G, J, Q, T, U, V, W, X and Y are as defined herein) useful as antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as headache, migraine and cluster headache. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20120122900A1
公开(公告)日：2012-05-17
申请号：US13293177
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/437 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US08883807B2
公开(公告)日：2014-11-11
申请号：US13884632
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
IPC分类号： A01N43/90 , A61K31/519 , A01N43/42 , A61K31/44 , C07D487/00 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02 , A61K31/506 , C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/506 , C07D487/04
摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08754096B2
公开(公告)日：2014-06-17
申请号：US13293166
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Heather E. Stevenson , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Heather E. Stevenson , Cheng Wang , C. Blair Zartman
IPC分类号： A61K31/4545 , A61K31/527 , A61P25/06 , C07D471/20
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺氮杂茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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公开(公告)号：US08912210B2
公开(公告)日：2014-12-16
申请号：US13293177
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , C. Blair Zartman
IPC分类号： A01N43/42 , A61K31/44 , C07D221/02
CPC分类号： A61K31/4545 , A61K31/435 , A61K31/438 , C07D471/10 , C07D471/20
摘要： The present invention is directed to piperidinone carboxamide azaindane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
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公开(公告)号：US20130231358A1
公开(公告)日：2013-09-05
申请号：US13884632
申请日：2011-11-10
申请人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
发明人： Ian M. Bell , Mark E. Fraley , Steven N. Gallicchio , Anthony Ginnetti , Helen J. Mitchell , Daniel V. Paone , Donnette D. Staas , Cheng Wang , Blair C. Zartman , Heather E. Stevenson
IPC分类号： C07D471/04 , C07D487/04
CPC分类号： C07D471/04 , A61K31/506 , C07D487/04
摘要： The present invention is directed to piperidinone carboxamide indane derivatives which are antagonists of CGRP receptors and useful in the treatment or prevention of diseases in which the CGRP is involved, such as migraine. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which CGRP is involved.
摘要翻译： 本发明涉及作为CGRP受体的拮抗剂的哌啶酮羧酰胺二氢化茚衍生物，其可用于治疗或预防涉及CGRP的疾病，例如偏头痛。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及CGRP的疾病中的用途。
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