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    Neuroblastoma treatment with taurolidine hydrolysis products
    21.
    发明授权
    Neuroblastoma treatment with taurolidine hydrolysis products 有权

    公开(公告)号：US11541061B2

    公开(公告)日：2023-01-03

    申请号：US16554186

    申请日：2019-08-28

    申请人： CorMedix Inc.

    发明人： Bruce Reidenberg ,  Robert DiLuccio

    IPC分类号： A61K31/549 ,  A61K31/18 ,  A61K31/047 ,  A61K9/00 ,  A61K9/14 ,  A61K47/34

    摘要： Neuroblastoma is a tumor primarily affecting children. The current standard of care is not curative except in the rare case of a surgically-resectable lesion, although very high survival rates have been documented for low-risk neuroblastoma and moderate-risk neuroblastoma. Taurolidine was developed as an anti-infective, but it has been found to have surprising oncolytic activity in cell cultures and now in a rodent cancer model. The efficacy in rodent model is superior to the efficacy in cell culture. This invention relates to the use of taurolidine hydrolysis products (tarultam and/or taurinamide and/or methylene glycol and/or selected combinations thereof) for the treatment of neuroblastoma in juvenile mammals.

    TAUROLIDINE TREATMENT FOR MYC-EXPRESSING TUMORS IN MAMMALIAN BODIES
    23.
    发明申请
    TAUROLIDINE TREATMENT FOR MYC-EXPRESSING TUMORS IN MAMMALIAN BODIES 有权

    公开(公告)号：US20220323451A1

    公开(公告)日：2022-10-13

    申请号：US17560453

    申请日：2021-12-23

    申请人： CorMedix Inc.

    发明人： Bruce Reidenberg ,  Robert DiLuccio

    IPC分类号： A61K31/549 ,  A61K31/132 ,  A61K9/16 ,  A61K31/047

    摘要： A method for treating a cancer which overexpresses any of N-myc genes, C-myc genes and/or L-myc genes in a mammalian body, the method comprising:
    administering a composition to the mammalian body, wherein the composition comprises at least one from the group consisting of taurolidine; taurultam; taurinamide; methylene glycol; taurultam and taurinamide in a ratio of 1 taurultam:7 taurinamide; and taurultam, taurinamide and methylene glycol in a ratio of 1 taurultam:7 taurinamide:1 methylene glycol.

    Field sterilizer and vascular connector kit
    25.
    发明授权
    Field sterilizer and vascular connector kit 有权

    公开(公告)号：US10478640B2

    公开(公告)日：2019-11-19

    申请号：US15471924

    申请日：2017-03-28

    申请人： CorMedix Inc.

    发明人： Bruce Reidenberg ,  Antony Pfaffle ,  Robert DiLuccio

    IPC分类号： A61L2/10 ,  A61N5/06 ,  A61M39/16 ,  A61M39/10

    摘要： Placement of a vascular access device (intravenous, intra-arterial and/or intra-osseous vascular access) in a non-sterile environment greatly increases the risk of infection via the vascular access device. This invention provides an approach for accomplishing sterilization of the site where vascular access will be attempted under non-sterile field conditions. In addition, this invention provides a sterile vascular connector pre-loaded with an antimicrobial, e.g., Taurolidine. Use of the vascular connector provides the antimicrobial concurrently with achieving vascular access, which limits the risk of infection despite access placement under non-sterile field conditions.